European Psychiatry - Volume 33 - March 2016

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S382 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
EV99
Therapeutic efficacy of original
anticonvulsant
meta-chloro-benzhydrylurea
(m-ch-BHU) in the treatment of
patients with a compulsive craving for
alcohol
T. Shushpanova ∗, N. Bokhan , A. Mandel , V. Lebedeva
1 Mental Health Research Institute, Biological Psychiatry, Tomsk,
Russia
2 Mental Health Research Institute, Administration, Tomsk, Russia
3 Mental Health Research Institute, Addictive States Department,
Tomsk, Russia
4 Mental Health Research Institute, Clinics, Tomsk, Russia
∗ Corresponding author.
Introduction The problemof the treatment of alcohol addiction is
very difficult due to the reoccurrence of relapses. One of the major
concepts of the formation of alcohol addiction is the concept of
epileptic origin of compulsive craving for alcohol.
Objective We investigated therapeutic efficacy of long-term dos-
ing of original anticonvulsant (m-ch-BHU) on symptoms of alcohol
withdrawal syndrome (AWS) in patients with a compulsive craving
for alcohol.
Methods Sixty-eight male alcoholic patients aged from 24 to
53 years with different levels of alcohol abuse were examined.
Type of course of alcoholism in examined patients was of middle-
progressing character. Clinical evaluation of state of patients was
carried out with traditional clinical description. Quantitative char-
acterization was conducted according to Hamilton Anxiety Scale
and Hamilton Depression Scale. m-ch-BHU was administered to
alcoholic patients at dose from300mg a day during 21 days against
the background of conventional medication as well as in post-
withdrawal period under various degrees of severity of affective
disorders.
Results Among affective disorders dysphoric symptoms have a
marked tropism for m-ch-BHU. Of the other clinical manifestations
in the structure of AWS cerebral diencephalic paroxysms, cardio-
vascular and myofascial symptoms have the most pronounced
sensitivity to the drug. In patients with complicated forms of
alcoholism application of m-ch-BHU is effective also in phase of
remission in spontaneously arising symptomcomplex of neuroveg-
etative manifestations of primary pathological craving for ethanol
called “dry abstinence”.
Conclusions Our data allows recommending the use ofm-ch-BHU
under outpatient conditions as an anti-recurrent and preventive
agent.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV100
Chronic psychiatric changes in a
severe post-traumatic brain injury
patient
J. Silva ∗, J. Mota , P. Azevedo
1 Magalhães Lemos Hospital, Inpatient C Unit, Porto, Portugal
2 Magalhães Lemos Hospital, Inpatient C Unit – Electroconvulsive
therapy Unit, Porto, Portugal
∗ Corresponding author.
Introduction Severe traumatic brain injury (TBI) causes
neuropsychiatric disturbances. Emotional and personality
disturbances seem to cause much more seriously handicap
than residual cognitive or physical disabilities. The progno-
sis may be poor associated with marked social impairment,
so a multidisciplinary approach team is required in order to
improve patient’s quality of life and reintegration in family and
society.
Objectives To summarize the latest literature about this field and
to present a case report.
Aim To explore and learnmore about chronic psychiatric changes
in severe post-traumatic brain injury and share with the scientific
community how challenging the approach of this entity can be.
Methods A brief review of the latest literature was performed,
using PubMed and the keywords “traumatic brain injury” and “psy-
chiatric changes”. A case report is presented.
Results Although SSRI, benzodiazepines, mood stabilizers and
antipsychotics are commonly used, new options are reported such
as methylphenidate and cholinesterase inhibitors. The presented
patient, a 27-year-old male, began with neuropsychiatric distur-
bances after a work-related fall from 9 meters high: convulsions
and alcohol compulsive drinking. Three years have passed and his
changes are still difficult to approach. Besides other medication,
such as benzodiazepines and mood stabilizers, flufenazine injec-
tions and naltrexone seemed to be determinant in his behaviour
and mood stabilization. He is also on a long-term alcoholism pro-
gramme.
Conclusions Although the understanding of TBI-associated neu-
ropsychiatric disorders has improved in the last decade, further
research is needed, such as randomized-controlled studies to study
new pharmacological and non-pharmacological approach.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV101
Clinical and demographic
characteristics of treatment seeking
online video game players
O. Simon∗ hebbi , A. Ochoa Godall , J. Eicher , C. Zumwald ,
C. Dickson
Centre du jeu excessif, Department of Psychiatry, Lausanne,
Switzerland
∗ Corresponding author.
Background and aim Within Switzerland, video game players
seeking specialised treatment are usually referred to gambling
addiction services. The Centre for Excessive Gambling (CJE) is a
specialised gambling addiction unit in Lausanne University Hos-
pital. Between 2003 and 2015 the service offered also support to
64 adults seeking treatment for videogaming-related disorders.
According to international literature, Internet disorder treatment
programmes have been developed. However, little is known about
clinical profile of users seeking treatment. Studies into Internet
or gaming disorders typically employ Internet survey methods or
use student samples. The current presentation will outline demo-
graphic and clinical features of video gamers receiving treatment
at the CJE.
Method Datawere collected from themedical records of 57 video
gamers seeking treatment at the CJE between 2003 and 2015.
Results The sample includes 93% men, mostly single (91%), with
an average age of 25 years ± 7. On average the sample spent
9 hours ± 5 per day playing video games. A disorder had emerged an
average of 3 years ago ± 3. The crisis preceding the first consultation
was familial (50%), emotional (29%) or professional (16%). Sixty-
five percent of the sample had a mood disorder and 20% reported
suicidal ideations.
Discussion Treatments should address comorbidities and family
problems associated with video game disorders. Offering consul-
tations for parents could be useful, even in absence of the young
player.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.