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S382

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

EV99

Therapeutic efficacy of original

anticonvulsant

meta-chloro-benzhydrylurea

(m-ch-BHU) in the treatment of

patients with a compulsive craving for

alcohol

T. Shushpanova

1 ,

, N. Bokhan

2

, A. Mandel

3

, V. Lebedeva

4

1

Mental Health Research Institute, Biological Psychiatry, Tomsk,

Russia

2

Mental Health Research Institute, Administration, Tomsk, Russia

3

Mental Health Research Institute, Addictive States Department,

Tomsk, Russia

4

Mental Health Research Institute, Clinics, Tomsk, Russia

Corresponding author.

Introduction

The problemof the treatment of alcohol addiction is

very difficult due to the reoccurrence of relapses. One of the major

concepts of the formation of alcohol addiction is the concept of

epileptic origin of compulsive craving for alcohol.

Objective

We investigated therapeutic efficacy of long-term dos-

ing of original anticonvulsant (m-ch-BHU) on symptoms of alcohol

withdrawal syndrome (AWS) in patients with a compulsive craving

for alcohol.

Methods

Sixty-eight male alcoholic patients aged from 24 to

53 years with different levels of alcohol abuse were examined.

Type of course of alcoholism in examined patients was of middle-

progressing character. Clinical evaluation of state of patients was

carried out with traditional clinical description. Quantitative char-

acterization was conducted according to Hamilton Anxiety Scale

and Hamilton Depression Scale. m-ch-BHU was administered to

alcoholic patients at dose from300mg a day during 21 days against

the background of conventional medication as well as in post-

withdrawal period under various degrees of severity of affective

disorders.

Results

Among affective disorders dysphoric symptoms have a

marked tropism for m-ch-BHU. Of the other clinical manifestations

in the structure of AWS cerebral diencephalic paroxysms, cardio-

vascular and myofascial symptoms have the most pronounced

sensitivity to the drug. In patients with complicated forms of

alcoholism application of m-ch-BHU is effective also in phase of

remission in spontaneously arising symptomcomplex of neuroveg-

etative manifestations of primary pathological craving for ethanol

called “dry abstinence”.

Conclusions

Our data allows recommending the use ofm-ch-BHU

under outpatient conditions as an anti-recurrent and preventive

agent.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1084

EV100

Chronic psychiatric changes in a

severe post-traumatic brain injury

patient

J. Silva

1 ,

, J. Mota

2

, P. Azevedo

1

1

Magalhães Lemos Hospital, Inpatient C Unit, Porto, Portugal

2

Magalhães Lemos Hospital, Inpatient C Unit – Electroconvulsive

therapy Unit, Porto, Portugal

Corresponding author.

Introduction

Severe traumatic brain injury (TBI) causes

neuropsychiatric disturbances.

Emotional and personality

disturbances seem to cause much more seriously handicap

than residual cognitive or physical disabilities. The progno-

sis may be poor associated with marked social impairment,

so a multidisciplinary approach team is required in order to

improve patient’s quality of life and reintegration in family and

society.

Objectives

To summarize the latest literature about this field and

to present a case report.

Aim

To explore and learnmore about chronic psychiatric changes

in severe post-traumatic brain injury and share with the scientific

community how challenging the approach of this entity can be.

Methods

A brief review of the latest literature was performed,

using PubMed and the keywords “traumatic brain injury” and “psy-

chiatric changes”. A case report is presented.

Results

Although SSRI, benzodiazepines, mood stabilizers and

antipsychotics are commonly used, new options are reported such

as methylphenidate and cholinesterase inhibitors. The presented

patient, a 27-year-old male, began with neuropsychiatric distur-

bances after a work-related fall from 9 meters high: convulsions

and alcohol compulsive drinking. Three years have passed and his

changes are still difficult to approach. Besides other medication,

such as benzodiazepines and mood stabilizers, flufenazine injec-

tions and naltrexone seemed to be determinant in his behaviour

and mood stabilization. He is also on a long-term alcoholism pro-

gramme.

Conclusions

Although the understanding of TBI-associated neu-

ropsychiatric disorders has improved in the last decade, further

research is needed, such as randomized-controlled studies to study

new pharmacological and non-pharmacological approach.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1085

EV101

Clinical and demographic

characteristics of treatment seeking

online video game players

O. Simon

, R. C

hebbi , A. Ochoa Godall , J. Eicher , C. Zumwald ,

C. Dickson

Centre du jeu excessif, Department of Psychiatry, Lausanne,

Switzerland

Corresponding author.

Background and aim

Within Switzerland, video game players

seeking specialised treatment are usually referred to gambling

addiction services. The Centre for Excessive Gambling (CJE) is a

specialised gambling addiction unit in Lausanne University Hos-

pital. Between 2003 and 2015 the service offered also support to

64 adults seeking treatment for videogaming-related disorders.

According to international literature, Internet disorder treatment

programmes have been developed. However, little is known about

clinical profile of users seeking treatment. Studies into Internet

or gaming disorders typically employ Internet survey methods or

use student samples. The current presentation will outline demo-

graphic and clinical features of video gamers receiving treatment

at the CJE.

Method

Datawere collected from themedical records of 57 video

gamers seeking treatment at the CJE between 2003 and 2015.

Results

The sample includes 93% men, mostly single (91%), with

an average age of 25 years

±

7. On average the sample spent

9 hours

±

5 per day playing video games. A disorder had emerged an

average of 3 years ago

±

3. The crisis preceding the first consultation

was familial (50%), emotional (29%) or professional (16%). Sixty-

five percent of the sample had a mood disorder and 20% reported

suicidal ideations.

Discussion

Treatments should address comorbidities and family

problems associated with video game disorders. Offering consul-

tations for parents could be useful, even in absence of the young

player.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1086