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S384

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

EV105

Sociodemographic characteristics and

clinical outcomes among patients

with comorbid alcohol dependence

and depressive spectrum disorders

E. Solodkaia

1 ,

, I. Loginov

1

, V. Sergina

1

, A. Zhurbuck

1

, S. Savin

2

,

H. Jian

3

1

Far Eastern State Medical University, Psychiatry and Narcology,

Khabarovsk, Russia

2

Computer Center of FEB RAS, Laboratory of medical information,

Khabarovsk, Russia

3

Harbin Medical University, Psychiatry, Harbin, China

Corresponding author.

Introduction

The accelerated development of substance depen-

dence with social disadaptation and delinquent behavior, which is

associated with the integration of pathological processes addictive

and mental pathology, is observed in most patients with comorbid

mental disorders.

Aims

We evaluated the association of sociodemographic charac-

teristics with clinical outcomes among patients with comorbidity

of alcohol dependence and depression.

Objectives

To study the structure and clinical features of depres-

sive spectrumdisorders with comorbid alcohol dependence among

males aged 18–60. Datawere collected at the Khabarovsk territorial

psychiatric clinic, and all participants provided written informed

consent prior to participation. Participants in the current study

consisted of 89 males with comorbid alcohol dependence and

depression (ICD-10 criteria).

Methods

The present study based on clinical examination and

interview, including data of demographic characteristics, family

background and remission. Logistic regressionwas used to evaluate

the associations of interest.

Results

Analyses showed that risk of relapse was higher among

males with low education and income level (

r

= 0.65;

r

= 0.55),

family destruction until puberty (

r

= 0.76), parental alcohol mis-

use (

r

= 0.74), authoritarian parenting style in childhood (

r

= 0.55),

conflict relationships with spouse (

r

= 0.80), “conflict” dominant

motivation for abstinence (

r

= 0.77), mood swings (

r

= 0.74) and

absence of treatment for depression (

r

= 0.80).

Conclusions

Integrative approach to treatment of patients with

comorbid alcohol dependence and depressive spectrum disorders

should take into consideration sociodemographic characteristics.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1090

EV106

Integrated approaches to the

treatment of pain syndrome in the

patients with drug addiction

I. Sosin

, Y. Chuev , O. Goncharova

Kharkov Medical Academy of Postgraduate Education, Narcology,

Kharkov, Ukraine

Corresponding author.

Introduction

Pain syndrome is integral acute sign of drug addic-

tion at psychoactive substance deprivation and is a severe urgent

state.

Objectives and aims

To work out integrated approaches to pain

syndrome cessation with combined pharmacotherapy and non-

pharmaceutical methods. To study dynamics of pain syndrome

reduction at application of the developed methods.

Methods

One hundred and eighty-nine opioid addicts (cessation

state) were examined. The treatment efficiency was evaluatedwith

visual analogue scale; Roland-Morris questionnaire; pain numeric

rating scale.

Results

Four innovative options of modified therapy for pain

authorized with the patents of Ukraine were proposed (with mem-

brane plasmapheresis, medical electrophoresis, laser therapy and

standard pharmacotherapy):

– pain syndrome cessation in opioid addicts is provided with

Tramadol (up to 600mg i/m), at intravascular laser hemother-

apy (wavelength 0.63mcm, power 2mW, 30–40min exposure, 3–4

days course);

– recurrent deprivation pain syndrome cessation is realized by

membrane plasmapheresis with intravascular laser blood irradi-

ation and i/m 1.0mL Ketanov solution 2–3 days;

– pain syndrome treatment in drug and alcohol addicts is provided

with Analgin and Sibazon by electrophoresis, current 1.5–5mA,

exposure 25–30min, 1–2 procedures daily;

– pain syndrome cessation in drug addicts is performed by injec-

tion of 0.5% Seduxen solution (up to 4.0mL), paracetamol – (up

to 0.4 g), 10% solution of sodium caffeine benzoate – 1.0–2.0mL

subcutaneously, at night – 0.5% seduxen 2.0–4.0mL, paracetamol

– 0.2–0.4 g.

Conclusions

Monitoring and statistical processing data proved

that the proposed methods give 1.5–2-fold growth in efficiency of

treatment for pain syndrome in drug addicts.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1091

EV107

Clinical and biological predictors of

the resistance to anti-smoking

therapy of tobacco dependent patients

O. Speranskaya

Serbsky National Research Centre for Social and Forensic Psychiatry,

tobacco dependence, Moscow, Russia

Objectives

The treatment resistance to anti-smoking drugs (NRT,

varenicline) remains one the most important problems of the effi-

cacy of antismoking programs.

The role of biological signs (EEF profile, genetic changers) in the

possibility of forthcoming resistance to anti-smoking drugs needs

investigation.

Aims

Thirty-one tobacco dependent patients, age 47–61, male,

smoking period more than 25 years, had the resistance to NRT (15)

ore varenicline (16) appeared after several successful quits. The

number of cigarettes was 28–60 per day.

Thirty male patients, age 42–59, smoking period 20 years with-

out therapy resistance were in the control group. The number of

cigarettes per day was 22–35.

EEG indices and genetic polymorphism of COMT were identified in

both groups of the patients.

Results

The patients with therapy resistance had special clinical

features of tobacco dependence: the prevalence of ideatory com-

ponent of tobacco craving. The maximum intensity (up to 4 points

in special scale) symptoms of craving to smoke, correlated with

high (82.7

±

0.1) level of alexithymia (

r

= .759,

P

< 0.01), low values

of alpha index of EEG (

P

< 0.05), the presence of double valin allele

of COMT (

P

= 0.0741).

Conclusion

The presence of at least one valin polymorfism allele

of

rs4680 COMT

gene might be the predictor of pharmacological

resistance to anti-smoking therapy, as well as low values of alpha

index of EEG and clinical signs.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1092