European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S381
Objectives The aim of this study is to evaluate the use of both
legal and illegal substances, and see the difference in consumption
patterns that occur in both men and women.
Methods Surveys have been conducted on consumer habits in
the past year among 84 inmates (60 women and 24 men) at the
prison Brians 1, interrogating both the consumption of illegal drugs
and consumer recreational drugs and routes of administration. Data
were analyzed using SPSS program.
Results A total of 57.1% had used illegal drugs. The most frequent
was cannabis, with 54.8% (62.5% men and 51.7% women), followed
by heroin, with 23.8% (29.2% in men and 21.7% in women) and
cocaine, with 14.3% (20.8% in men and 11.7% women).
Use of legal drugs was 45.2% (50% inmen and 43.3%women). In this
case, the greatest differences were obtained in the use of bupropion
(26.7% women versus 0% men), new generation anticonvulsants
such as gabapentin and pregabalin (31.7% women and 12.5% men)
and the use of intranasal route of administration (31.7% women
versus 0% formen). At the other extremewe findmore abuse benzo-
diazepines abuse in men (45.8 versus 20% in women) and sedative
antipsychotics (37.5% vs. 8.3%)
Conclusions Although there is a serious problem with the mis-
use of legal psychotropic drugs by inmates in prisons, there is still
greater consumption of illegal substances.
Men’s consumption pattern is more “traditional” (predominance of
illegal substances and “classical” legal substances orally).
Women’s consumption pattern is more experimental at both the
use of new psychoactive drugs and the use of alternative routes of
administration.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV97
Calcium as a treatment option for
alcohol dependence
R. Schuster ∗ oopmann , F. Kiefer
Central Institute of Mental Health- University Heidelberg,
Departement of Addictive Behavior and Addiction Medicine,
Mannheim, Germany
∗ Corresponding author.
In the last couple of decades anti-craving drugs have been devel-
oped. Acamprosate was described as an effective treatment option
to support alcohol abstinence with a low side effect profile. More-
over its molecular mode of action is highly controversial. Recently,
calcium salt was described to be the active part of Acamprosate.
Using a clinical sample of placebo (n = 10) vs. Acamprosate-treated
(n = 19) abstinent alcohol-dependent patients, we measured cal-
cium plasma concentrations after the 1st, 2nd and 3rd month after
the treatment commenced. Before treatment, the same physiolog-
ical calcium concentration of about 2.4mmol/l was found in both
groups respectively. We found significant correlations in the Acam-
prosate group while no correlations in the placebo group were
observed.
The very well regulated extracellular calcium serum concentra-
tion seems to get out of balance in association with the severity
of alcohol dependence in inpatients during withdrawal.
Accordingly, in another clinical sample (n = 57) we found a negative
correlation between calcium serum concentration and craving (r2=
0.125; P = 0.011) on day 1 of detoxification. The measurement of
craving was carried out by a self-rating scale, the Obsessive Com-
pulsive Drinking Scale (OCDS). Furthermore a low calcium level
correlated with high breathalyser readings and the number of alco-
hol inpatient detoxification’s.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV98
Disrupted homeostasis during chronic
ethanol consumption associated with
specific mechanism of endogenous
neurosteroids activity
T. Shushpanova ∗, N. Bokhan , A. Mandel , A. Solonsky ,
T. Novozheeva , A. Semke , V. Lebedeva , T. Kazennykh ,
V. Udut (Deputy Director) , G. Arbit , V. Philimonov ,
E. Markova
1 Mental Health Research Institute, Biological Psychiatry Department,
Tomsk, Russia
2 Mental Health Research Institute, Addictive States Department,
Tomsk, Russia
3 Mental Health Research Institute, Endogenous Disorders
Department, Tomsk, Russia
4 Mental Health Research Institute, Clinics, Tomsk, Russia
5 Mental Health Research Institute, Scientific secretary, Tomsk, Russia
6 Pharmacology and Regenerative Medicine Research Institute,
Tomsk, Russia
7 National Research Tomsk Polytechnic University, Biotechnology and
Organic Chemistry Department, Tomsk, Russia
8 Basic and Clinical Immunology Institute, Laboratory of
Neuroimmunology, Novosibirsk, Russia
∗ Corresponding author.
Introduction Neurobiological research describes one of mecha-
nisms overlap in the Cortico-Striatal-Limbic Circuit (CSLC), which
can be disrupted due to chronic stress and alcohol abuse that pri-
marily modulated by the hypothalamic-pituitary-adrenal (HPA)
axis, from which cortisol is an end-product.
Objectives To investigate the effects of chronic stimulant abuse
on the CSLC. This was examined by relating cortisol levels with
grey matter volume in brain structures associated with addiction
and stress.
Aims We hypothesized that stimulant-dependent individuals
show increased cortisol levels and abnormalities in the CSLC. We
further hypothesized relationships between altered grey matter
volume and increased cortisol levels in the patients.
Methods Twenty-two alcohol-dependent individuals, men only
and 21 healthy volunteers (matched for age and gender) underwent
an assessment session. Cortisol, DHEA and DHEA-S was assessed in
blood plasma. Mood, impulsivity and compulsivity were measured
by clinical instruments.
Results Alcohol-dependent individuals showed higher levels of
cortisol in blood plasma, and decreased levels of progesterone and
its metabolites DHEA and DHEA-S, which were associated with
distinct expression in impulsivity and compulsivity in alcoholic
patients. Indices of these steroids were changed compared with
healthy persons. Plasma cortisol was positively correlated with the
duration of alcohol use. The relationships observed between cor-
tisol, progesterone and its metabolites: DHEA and DHEA-S may be
explained by abnormal functioning of HPA axis.
Conclusions Optimizing of disrupted homeostasis during chronic
ethanol consumption being provided with specific mechanism by
manipulation of endogenous neurosteroids activity may prove a
beneficial pharmacotherapeutic strategy in the intervention of
alcohol abuse.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.