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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S381

Objectives

The aim of this study is to evaluate the use of both

legal and illegal substances, and see the difference in consumption

patterns that occur in both men and women.

Methods

Surveys have been conducted on consumer habits in

the past year among 84 inmates (60 women and 24 men) at the

prison Brians 1, interrogating both the consumption of illegal drugs

and consumer recreational drugs and routes of administration. Data

were analyzed using SPSS program.

Results

A total of 57.1% had used illegal drugs. The most frequent

was cannabis, with 54.8% (62.5% men and 51.7% women), followed

by heroin, with 23.8% (29.2% in men and 21.7% in women) and

cocaine, with 14.3% (20.8% in men and 11.7% women).

Use of legal drugs was 45.2% (50% inmen and 43.3%women). In this

case, the greatest differences were obtained in the use of bupropion

(26.7% women versus 0% men), new generation anticonvulsants

such as gabapentin and pregabalin (31.7% women and 12.5% men)

and the use of intranasal route of administration (31.7% women

versus 0% formen). At the other extremewe findmore abuse benzo-

diazepines abuse in men (45.8 versus 20% in women) and sedative

antipsychotics (37.5% vs. 8.3%)

Conclusions

Although there is a serious problem with the mis-

use of legal psychotropic drugs by inmates in prisons, there is still

greater consumption of illegal substances.

Men’s consumption pattern is more “traditional” (predominance of

illegal substances and “classical” legal substances orally).

Women’s consumption pattern is more experimental at both the

use of new psychoactive drugs and the use of alternative routes of

administration.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1081

EV97

Calcium as a treatment option for

alcohol dependence

R. Schuster

, A. K

oopmann , F. Kiefer

Central Institute of Mental Health- University Heidelberg,

Departement of Addictive Behavior and Addiction Medicine,

Mannheim, Germany

Corresponding author.

In the last couple of decades anti-craving drugs have been devel-

oped. Acamprosate was described as an effective treatment option

to support alcohol abstinence with a low side effect profile. More-

over its molecular mode of action is highly controversial. Recently,

calcium salt was described to be the active part of Acamprosate.

Using a clinical sample of placebo (

n

= 10) vs. Acamprosate-treated

(

n

= 19) abstinent alcohol-dependent patients, we measured cal-

cium plasma concentrations after the 1st, 2nd and 3rd month after

the treatment commenced. Before treatment, the same physiolog-

ical calcium concentration of about 2.4mmol/l was found in both

groups respectively. We found significant correlations in the Acam-

prosate group while no correlations in the placebo group were

observed.

The very well regulated extracellular calcium serum concentra-

tion seems to get out of balance in association with the severity

of alcohol dependence in inpatients during withdrawal.

Accordingly, in another clinical sample (

n

= 57) we found a negative

correlation between calcium serum concentration and craving (

r

2

=

0.125;

P

= 0.011) on day 1 of detoxification. The measurement of

craving was carried out by a self-rating scale, the Obsessive Com-

pulsive Drinking Scale (OCDS). Furthermore a low calcium level

correlated with high breathalyser readings and the number of alco-

hol inpatient detoxification’s.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1082

EV98

Disrupted homeostasis during chronic

ethanol consumption associated with

specific mechanism of endogenous

neurosteroids activity

T. Shushpanova

1 ,

, N. Bokhan

2

, A. Mandel

2

, A. Solonsky

1

,

T. Novozheeva

1

, A. Semke

3

, V. Lebedeva

4

, T. Kazennykh

5

,

V. Udut (Deputy Director)

6

, G. Arbit

7

, V. Philimonov

7

,

E. Markova

8

1

Mental Health Research Institute, Biological Psychiatry Department,

Tomsk, Russia

2

Mental Health Research Institute, Addictive States Department,

Tomsk, Russia

3

Mental Health Research Institute, Endogenous Disorders

Department, Tomsk, Russia

4

Mental Health Research Institute, Clinics, Tomsk, Russia

5

Mental Health Research Institute, Scientific secretary, Tomsk, Russia

6

Pharmacology and Regenerative Medicine Research Institute,

Tomsk, Russia

7

National Research Tomsk Polytechnic University, Biotechnology and

Organic Chemistry Department, Tomsk, Russia

8

Basic and Clinical Immunology Institute, Laboratory of

Neuroimmunology, Novosibirsk, Russia

Corresponding author.

Introduction

Neurobiological research describes one of mecha-

nisms overlap in the Cortico-Striatal-Limbic Circuit (CSLC), which

can be disrupted due to chronic stress and alcohol abuse that pri-

marily modulated by the hypothalamic-pituitary-adrenal (HPA)

axis, from which cortisol is an end-product.

Objectives

To investigate the effects of chronic stimulant abuse

on the CSLC. This was examined by relating cortisol levels with

grey matter volume in brain structures associated with addiction

and stress.

Aims

We hypothesized that stimulant-dependent individuals

show increased cortisol levels and abnormalities in the CSLC. We

further hypothesized relationships between altered grey matter

volume and increased cortisol levels in the patients.

Methods

Twenty-two alcohol-dependent individuals, men only

and 21 healthy volunteers (matched for age and gender) underwent

an assessment session. Cortisol, DHEA and DHEA-S was assessed in

blood plasma. Mood, impulsivity and compulsivity were measured

by clinical instruments.

Results

Alcohol-dependent individuals showed higher levels of

cortisol in blood plasma, and decreased levels of progesterone and

its metabolites DHEA and DHEA-S, which were associated with

distinct expression in impulsivity and compulsivity in alcoholic

patients. Indices of these steroids were changed compared with

healthy persons. Plasma cortisol was positively correlated with the

duration of alcohol use. The relationships observed between cor-

tisol, progesterone and its metabolites: DHEA and DHEA-S may be

explained by abnormal functioning of HPA axis.

Conclusions

Optimizing of disrupted homeostasis during chronic

ethanol consumption being provided with specific mechanism by

manipulation of endogenous neurosteroids activity may prove a

beneficial pharmacotherapeutic strategy in the intervention of

alcohol abuse.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1083