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S386

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Objective

Nicotine dependence is a worldwide health problem

and the second cause of death worldwide. This article aims to

present the improvement in the technique used by us. The results

of the implementation of the treatment program with the use of

varenicline as a specific medicine for nicotine dependence during

admission to a clinic for chemical dependency treatment. We also

demonstrate that this treatment is possible and safe for patients

with comorbid psychiatric disorders and drug use disorders.

Methods

Between August 2012 and August 2013, 98 patients

were evaluated in a clinic for psychiatric and drug use treatment

in Rio de Janeiro, Brazil. The treatment consisted of a smoking

cessation therapy concurrently with the psychiatric treatment.

These patients had used pharmacological therapy associated with

intensive cognitive behavioral therapy, occupational therapy and

moderate physical activity. In addition to the associated therapy,

smokingwas limited to three cigarettes daily beginning the first day

of hospitalization. The drug use disorders and psychiatric illnesses

were treated as usual.

Results

The patients adhered to the treatment. Hundred percent

of the treatment group were discharged from the clinic such as

tobacco abstainers. The percentage of abstinence in patients after

discharge according to previous assessments (2008–2009) with

follow-up of 18 months was 51%. Results of the current study are

still under evaluation.

Conclusions

Behavioral group therapy and physical activities can

be important allies for varenicline. Behavioral changes also exert

great influence in the maintenance of abstinence.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1096

EV112

Hereditary influence in alcohol

dependence

J. Teixeira

1 ,

, G . P

ereira

2 , T. M

ota

2 , J. C

abral Fernandes

2

1

Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal

2

Lisbon’s Psychiatric Hospital Center, UTRA, Lisbon, Portugal

Corresponding author.

Introduction

Alcohol dependence is one of the psychiatric dis-

orders for which hereditary influence is strongest. In fact, the

importance of genetic factors in transmission of vulnerability to

alcohol dependencewas first described in literaturemany years ago

by psychiatrists who dedicate to its study. That vulnerability may

be explained by an epigenetic model in which biological heredi-

tary factors associate with environmental factors to cause alcohol

dependence.

Objectives

Study the influence of genetic factors on alcohol

dependence.

Methods

During 4 consecutive months a sample of alcoholic

patients was collected from the Alcohol Treatment Unit of CHPL

(inpatients and outpatients). Biographic data, patient’s psychiatric

diagnosis and family history of alcohol dependence or of depen-

dence of other drugs were recorded.

Results

Initial sample included 122 patients. After exclusion of

patients who were also hospitalized in that period, the final sample

included 102 patients (26% female), with a mean age of 48 years

old. Main patients’ diagnosis was alcohol dependence but most of

them (52%) presented psychiatric comorbidity. Most patients (55%)

had family history of alcohol dependence or dependence of other

substances, 26% did not have and 19% did not know. For 61% of

patients, the father and/or mother were the affected relative. Most

patients (61%) who had a family history of alcohol dependence or

dependence of other substances had 2 or more affected relatives.

Conclusions

Most patients with alcohol dependence have family

history of alcohol dependence or dependence of other substances,

usually in more than 1 relative, which must be taken in account

during treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1097

EV113

Treatment of tobacco dependence in

Romanian women – a vulnerable

population that needs a more

personalized approach

L. Trofor

1 ,

, R. Gherghesanu

1

, R. Chirita

1

, A. Trofor

2

1

Clinic of Psychiatric Diseases, Psychiatry I, Iasi, Romania

2

Clinic of Pulmonary Diseases, Pulmonology I, Iasi, Romania

Corresponding author.

Background

Women face unique and greater health risks from

smoking than men and have a different nicotine dependence pat-

tern.

Aim

To design a personalized approach for women addressing

Romanian tobacco dependence treatment centers to quit smoking.

Material and methods

A group of 68 smoking women received

a 3 months tobacco dependence treatment intervention, consist-

ing of 3 DVD educational sessions, 20minutes each and a face to

face cognitive – behavioral counseling intervention, emphasiz-

ing particularities of tobacco dependence in women (pregnancy

risks, passive smoking, female hormones configuration, nicotinic

receptors interactions, efficacy of nicotine dependence therapy

according to gender, etc.).

Results

Females under study were heavy smokers (17.16

±

8.03

SD packs cigarettes/years) with high nicotine dependence scores

(6.52

±

6.03 SD).

Abstinence rate evaluated in end of treatment (3EOT) phase by an

office visit (self-declared abstinence and exhaled carbon monoxide

validation) was 38% and increased at 44.1% at 6 months follow-up

when evaluated by a telephone contact visit (6TCV).

Conclusions

Personalized tobacco dependence treatment

approach, focusing on specific women tobacco use concerns

increased abstinence rates, comparatively to previous data in

women not benefiting educational DVD and face to face sessions

[1] .

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Reference

[1] Trofor L, Barnea E, Bucur D, Miron R, Bodescu M, Chirila C, et al.

Smoking cessation rates in women versus men – outcomes of

a reimbursed tobacco dependence treatment program. P 4462.

ERJ 2014;44(Suppl. 58).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1098

EV114

Cognitive factors in social adaptation

of opium addicts in remission

L. Tursunkhodjaeva

1 ,

, L . M

uzaffarova

2

1

Tashkent, Uzbekistan

2

Tashkent Institute of Physicians’ Post-Graduate Study, Academic

Department of Addiction Medicine and Adolescent Psychopathology,

Tashkent, Uzbekistan

Corresponding author.

Given significant influence of factors contributing or preventing

social adaptation of drug addicts after termination of drug abuse

on the stabilization of remission, their study is quite a challenge.

To study cognitive factors in social adaptation of opium addicts in

remission, a patient’s ability to predict people’s behavior in various

everyday situations, to discern intentions, feelings and emotional

states of a person by non-verbal and verbal expression we used

M. Sullivan’s method in examination of 75 opium addicts at the

Republican Tertiary Detox Center.