European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S387
More than 80% of the patients demonstrated lowscores in a number
of subtests, such as “a story to be completed”, “a verbal expres-
sion” and “a story to be extended”. That was the evidence for the
patients’ poor understanding association between behavior and its
consequences, which can cause them to get into conflict or danger-
ous situations. The patients had poor ability to understand changes
in initial meanings of verbal reactions by the context of the sit-
uation caused. They poorly discerned various meanings one and
the same verbal messages may have by the character of relation-
ships between people and peculiarities of communication. Even
during the period of prolonged withdrawal, the patients are found
to poorly discern associations between behavior and outcomes, to
misunderstand character of social relationships, and find it difficult
to predict people’s behavior. All above makes difficult the process
of interaction with the persons surrounding them, reduces possi-
bilities for social adaptation, prevent stabilization of remission and
poses the risk of the addiction recurrence.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV115
Nalmefene for daily consumption of
alcohol
J. Valdés Valdazo ∗, L.T. Velilla Diaz , C. Martínez Martínez ,
A. Serrano García , C. Manso Bazus , C. Llanes Álvarez
1 Leon, Spain
2 Caule, Psychiatry, Leon, Spain
3 Complejo Asistencial Zamora, Psychiatry, Zamora, Spain
∗ Corresponding author.
Introduction The level of high-risk alcohol consumption WHO is
estimated at more than 40mg for women and 60mg for men.
Nalmefene is a new treatment that breaks the cycle of continued
use of alcohol.
Methodology A sample of 18 patients of a Mental Health Centre
in the province of Leon alcohol dependent and high consumption
They received nalmefene 18mg daily continuous treatment for 6–9
months is appreciate the adherence of patients and the
efficacy, tolerability and impact on physical health.
Results We appreciate reduction in the amount of alcohol
ingested observed by both the patient and their relatives without
any cases of neglect and few side effects.
We got two patients leave the alcohol completely and an average
decline in consumption over 9 Basic Units of Drink.* (90 g).
We observed improvement in the quality of life in patients with
multiple pathologies and difficult social situation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV116
A case of marchiafava bignami disease
with frontal cortex involvement and
late onset, long-lasting psychiatric
symptoms
C. Vecchi ∗ ramaglia Feggi oppola i Marco
A. Venesia elicato Chieppa e Marchi
R. Cantello eppegno
1 Università del Piemonte Orientale, Translational Medicine, Novara,
Italy
2 AOU Maggiore della Carità, Psychiatry, Novara, Italy
∗ Corresponding author.
Aims To describe the case and management of a patient with
marchiafava bignami disease (MBD) with frontal cortical lesions,
no specific symptoms at first referral to the emergency room, and
late onset of atypical psychiatric symptoms.
Methods We report the case of a 44-year-old patient with
a history of chronic alcohol abuse, eventually diagnosed with
MBD.
Results Magnetic resonance showed lesions in the splenium and
in the body of corpus callosum and bilateral lesions of the frontal
cortex. The patient showed late-onset atypical psychiatric symp-
toms, which were drug resistant.
Conclusions The case we describe seems to support the existing
few ones describing cortical involvement in MBD, which suggest
that this is associated with a poorer prognosis. Psychiatric symp-
toms may be challenging to treat because of drug resistance. The
involvement of psychiatrists together with neurologists and radiol-
ogists, with a consultation–liaison approach has proved important
for the achievement of diagnosis and of the most appropriate man-
agement and treatment for this patient.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV117
Alexithymia in a sample of
alcohol-dependent patients: Clinical
correlations and cognitive patterns
R. Vecchiotti ∗, L. Orsolini , M. Panichi , M. Marconi ,
A. Valchera
1 Villa S. Giuseppe Hospital, Hermanas Hospitalarias, Department of
Psychiatry, Ascoli Piceno, Italy
2 Polyedra, Research, Teramo, Italy
3 Maastricht University, Department of Psychiatry and
Neuropsychology, Maastricht, Netherlands
4 University of Hertfordshire, School of Life and Medical Sciences,
Hatfield-Herts, United Kingdom
∗ Corresponding author.
Introduction Alexithymia represents a personality construct,
characterized by an inability in identifying and verbally describ-
ing own and others’ emotions. According to the recent research
on emotional dysregulation and the alexithymic construct, it has
been described a positive correlation between alcoholism and
alexithymia. The present study aims to evaluate the presence of
alexithymia in a sample of alcohol dependant patients and, there-
fore, analyze how the presence of these alexithymic traits may
influence/interact with a range of cognitive processes such as
the anger rumination, metacognitive capabilities and dissociative
experiences.
Methods A sample of 40 alcohol dependant inpatients affected
with alcohol dependence and alcohol-related issueswere recruited,
evaluated and compared with a sample of 40 healthy controls.
A clinical evaluation and a complete clinical and psychological
assessment were carried out in order to investigate alcohol-related
clinical patterns, alexithymia construct, anxiety and depression
symptomatology and cognitive pattern.
Results Subjects with alcohol addiction show higher total scores
in all tests except the scale that evaluates anxiety, compared to
healthy controls. Finally, a factorial ANOVA analysis demonstrated
that alcoholism seems to be determined by the lack of emotional
recognition from which derives a dissociative state, which conse-
quently generates a depressive rumination.
Conclusions According to the recent literature, the present study
identifies a significant proportion of alexithymic patients within
the sample of subjects affected by alcohol-related disorders. Other
clinical variables (i.e. depression, pathological anxiety-related
worry, anger rumination, dissociation and metacognitive capabili-
ties) mirror a specific cognitive pattern in the sample of alcoholics
rather than the healthy group.