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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S379

Conclusions

The data reflect a 92% reduction in alcohol use after

6 months of the administration of paliperidone palmitate.

We can say that paliperidone palmitate is effective in reducing

alcohol use in patients with dual diagnosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1074

EV90

Chronic ketamine use increases serum

levels of brain-derived neurotrophic

factor

V. Ricci

1 ,

, G. Martinotti

2

1

Department of Psychiatry, Department of Psychiatry, Aosta, Italy

2

University “G.d’Annunzio”, Department of Neuroscience – Imaging

– and Clinical Sciences, Chieti, Italy

Corresponding author.

Rationale

Ketamine is a non-competitive

N

-methyl-

d

-aspartate

(NMDA) receptor antagonist which interferes with the action of

excitatory amino acids (EAAs) including glutamate and aspar-

tate. The use of ketamine at subanaesthetic doses has increased

because of its psychotomimetic properties. However, long-term

ketamine abuse may interfere with memory processes and inhibit

the induction of long-term potentiation (LTP) in the hippocampus,

an effect probably mediated by its NMDA antagonist action. Neu-

rotrophins such as brain-derived neurotrophic factor (BDNF) and

nerve growth factor (NGF) serve as survival factors for selected pop-

ulations of central nervous system neurons, including cholinergic

and dopaminergic neurons. In addition, neurotrophins, particularly

BDNF, may regulate LTP in the hippocampus and influence synaptic

plasticity.

Objectives

The purpose of this study was to test the hypothesis

that ketamine use in humans is associatedwith altered serumlevels

of neurotrophins.

Methods

We measured by enzyme-linked immunosorbent assay

the NGF and BDNF serum levels in two groups of subjects: frequent

ketamine users and healthy subjects.

Results

Our data show that BDNF serum levels were increased in

chronic ketamine users as compared to healthy subjects, while NGF

levels were not affected by ketamine use.

Conclusion

These findings suggest that chronic ketamine intake

is associated with increases in BDNF serum levels in humans. Other

studies are needed to explore the pharmacological and molecular

mechanism by which ketamine, and/or other NMDA antagonists,

may induce modification in the production and utilization of BDNF

and alter normal brain function.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1075

EV91

Related factors with substance use in

old adults

E. Ros-Cucurull

1 , 2 , 3 ,

, C . D

aigre

1 , 2 , 3 , L . G

rau-Lopez

1 , 2 , 3 ,

C. Barral

1 , 2 , A .C

. Abad

1 , 2 , M .

B. Ortiz

4 , R. M

artinez-Arias

1 ,

E. Garcia

1 , C. C

ardona

1 , C. J

acas

1 , M.

Casa

s 1 , 3 , C . R

oncero

1 , 2 , 3

1

Hospital Vall d’Hebron, Psychiatry, Barcelona, Spain

2

Addiction and Dual Diagnosis Unit- Vall d’Hebron, Psychiatry,

Barcelona, Spain

3

Universidad Autonoma, Psychiatry, Barcelona, Spain

4

Hospital Mare de Deu de la Mercè, Psychiatry, Barcelona, Spain

Corresponding author.

Intro

Substance use disorder is a growing phenomenon among

the elderly. It is undervalued, misidentified, underdiagnosed and

poorly treated.

Aim

Study prevalence, characteristics and risk factors associated

with drug use among the elderly.

Method

A 6-month prospective study of substance use in elderly

patients (65+) who attended the addiction and dual diagnosis unit,

Vall d’Hebron University Hospital.

Results

Fifty-nine patients evaluated, mean age 70.04 years, 60%

men. A total of 49.1% are married, 35.8% divorced and 53.8% live

with a partner and/or children. A total of 67.3% have basic studies

and 78.8% are pensioners. A total of 82.7% have no criminal record.

Medical comorbidity presents in 90.4% of the sample, psychiatric

and addictive family background in 42.3% and 37.3%. A total of 67.3%

have comorbid Axis I (mainly affective disorders) and 25% Axis II

(cluster B most). A total of 7.7% attempted suicide at least once.

The main substance is alcohol (76.9%), followed by prescription

drugs (19.3%). A total of 28.8% are multi-drug users. A total of 67.3%

have used tobacco in their life and 63.5% are currently dependent.

The average age of onset for a disorder for any substance consump-

tion is 28.19, being lower for alcohol and illegal substances and

higher for prescription drugs.

A total of 61.5% have gone through treatment before but only 32.7%

has been admitted because of addiction. The adherence rate is 90.4%

and the relapse rate 8.3% at first month and 13% at 6 months.

Conclusions

Old adults present differences compared to overall

drug user population: prevalence by gender is almost equal, lower

Axis II, less multi-drug consumption and both dropout and relapse

rate are drastically lower.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1076

EV92

Dual diagnosis patients at first

admission in an acute psychiatric

ward. Trend over a decade

A. Rossi

1 ,

, A . L

ombardi

1 , C. G

ramaglia

1 , M.

Cavanna

1 , F. B

ert

2 ,

R. Siliquin

i 2 , P. Z

eppegno

1

1

Università del Piemonte Orientale, Traslational Medicine, Novara,

Italy

2

Università degli Studi di Torino, Scienze della Sanità Pubblica e

Pediatriche, Torino, Italy

Corresponding author.

Introduction

Dual diagnosis (DD) is the coexistence of a Psychi-

atric Disorder (PD), and Substance Use Disorder (SUD). The increase

of DD observed in recent years has caused serious problems to both

public and private services organization.

Aims

Our aim is to assess the prevalence and features (including

clinical and sociodemographic ones) of DD over a decade, compar-

ing the period 2003–2004 and 2013–2014.

Methods

We performed a retrospective study retrieving the

medical records of DD patients at their first admission to the

Psychiatry Ward AOU “Maggiore della Carità”, Novara, Italy.

Sociodemographic and clinical features were recorded. The two

groups of patients (2003–2004 vs. 2013–2014) were compared.

Results

In both periods DD patients are usually Italian male, aged

19–40, single. They have usually attended middle school, live with

parents, have two or more brothers and/or sisters but no kids. DD

patients in 2003–2004 and 2013–2014 showed differences as far

as employment and diagnosis are concerned. The first were more

frequently employed than the latter: moreover the 2003–2004

patients were more frequently diagnosed with a personality disor-

der while the 2013–2014 patients had mixed diagnoses. We have

found differences in the possible predictors of substance abuse in

the two periods, as well.

Conclusions

The identification of changes in the prevalence of

first admissionDDpatients and their clinical and sociodemographic

features may help to highlight an evolving pattern of substance use