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S376

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

among all study group (

n

= 498) the depressed patients presented

higher proportion of rape history (25% vs. 9.5%,

P

= 0.001), of sui-

cide attempts (43.8% vs. 25%,

P

= 0.001) with only a trend of shorter

cumulative retention in MMT of mean 9.4y (95% CI 7.8–10.7) vs.

11.5 (95% CI 10.5–12.5,

P

= 0.07).

Conclusion

Despite cocaine and benzodiazepine abuse on admis-

sion, depressed succeeded similarly to the non-depressed in the

first year retention in treatment. Intervention is recommended

since admission, as their long-term retention seems to be shorter,

later on, and their ability to discontinue cocaine and benzodi-

azepine abuse is clearly hampered.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1065

EV81

What triggers help-seeking behaviour

in “early stage” alcohol-dependent

drinkers

P. Ponizovskiy

, A. Gofman

Moscow Research Institute of Psychiatry, Department of mental

disorders complicated by substance abuse, Moscow, Russia

Corresponding author.

Abstract

In early stages of alcohol addiction negative effects of

alcohol often remain invisible to the patient or underestimated and

considered “normal” by him. However, there is a cohort of alcohol

drinkerswho seek outpatient treatment in early stages of addiction.

The study was conducted in order to investigate the triggers for

seeking therapy in early stages of alcohol dependence when com-

pulsive drinking, impaired control and increased alcohol tolerance

are developed, but withdrawal symptoms followed by relief drink-

ing are not yet observed. Fourty-six out-patients (31 men and 15

women, mean age 38

±

7 years) were studied bymeans of audit and

clinical interview.

The average duration of alcohol abuse was 8,7

±

5 years, the mean

daily dose of alcohol was 10

±

4 standard drinks. Most of the

patients were drinking alcohol from several times a week to several

times a month.

The decision to seek treatment in most cases was pushed by

patients’ family members because of the recurrent interpersonal

problems caused or exacerbated by the effects of alcohol – 70%

(

n

= 32). Other triggers included: job instability – 35% (

n

= 16); alco-

hol blackouts – 26% (

n

= 12); exacerbations of symptoms of existing

physical conditions – 24% (

n

= 11); legal problems – 7% (

n

= 3).

Alcohol consumption in early stages of alcohol addiction can affect

nearly every aspect of a patient’s life. The triggers which promote

treatment-seeking behaviour should be addressed in the course of

the treatment in order to encourage recovery and prevent transi-

tion to more severe stages of the disease.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1066

EV82

Misuse of pregabalin: Case series and

literature review

N.E. Suardi , M. Preve

, M.

Godio , E. Bolla , R.A. Colombo ,

R. Traber

Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio,

Switzerland

Corresponding author.

Introduction

Pregabalin is widely used in neurology, psychiatry

and primary healthcare, and recently in literature different stud-

ies explain the possible misuse

[1,2] . P

regabalin has shown greater

potency inpreclinicalmodels of epilepsy, pain and anxiety, andmay

have potential in the treatment of cocaine addiction

[3] . T

he pur-

pose of this report is to review the clinical evidence for the potential

of abuse and misuse of pregabalin. We propose ten different cases

and literature review.

Method

Ten inpatients with misuse of pregabalin were assessed

with: the SCID-P, Anamnestic Folio, HAM-A and DAST. We con-

ducted a systematic review of the literature (PubMed, Embase,

PsychInfo), using the terms “pregabalin”, “misuse”.

Results

All our patients present: cocaine, alcohol and/heroin pos-

itive in drugs urine screening at admission; a significant high level

of total anxiety at the HAM-A Tot (

P

< .001), and especially at the

item 7 (

P

< .001); the misuse of pregabalin is made for sniffing;

the predominant symptoms assessed were euphoria, psychomotor

activation and sedation.

Discussion and conclusion

Schifano F et al.,

[1,2] s

uggest that

pregabalin should carefully prescribe in patients with a possible

previous history of drug abuse. Our result identifies a particular

population the misuse pregabalin that are abuser of cocaine, alco-

hol and/or heroin. Further research is warranted to replicate our

clinical and qualitative observations and, in general, quantitative

studies in large samples followed up over time are needed. Method-

ological limitations, clinical implications and suggestions for future

research directions are considered.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

References

[1] Schifano F. SSP 2014.

[2] Schifano F, et al. SSP 2011.

[3] de Guglielmo G, et al. SSP 2013.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1067

EV83

Quetiapine XR reduce impulsivity and

dissociation in a sample of alcoholic

patients

M. Godio , M. Preve

, N.E

. Suardi , E. Bolla , R.A. Colombo ,

R. Traber

Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio,

Switzerland

Corresponding author.

Introduction

Alcohol dependence (AD) is a major public health

problem. Currently, three drugs for the treatment of AD have been

approved: acamprosate, disulfiramand oral naltrexone. Quetiapine

XR is an atypical antipsychotic has been shown to be a promising

medication for the treatment of alcoholism

[1,2] .

The aim of our

study is evaluate quetiapine efficacy on impulsivity in a sample of

alcoholic patients.

Method

A sample of alcoholic patients (

n

= 40) was assessed at

the entrance and 2 months with: SCID-P, Brief-Temps, BIS-11,

GSR, BPRS, SCI-DER, and CGI. The medium dosage of quetiapine

is 300mg.

Results

Using the last observation carried forward, themean total

BIS score decreased from 60.8 at baseline to 40.2 at the final visit

(

P

= .03). More pronounced improvement was observed in motor

impulsiveness (

P

< .03) and attentional impulsiveness (

P

< .05) com-

pared with non-planning impulsiveness (

P

= .09). We observed an

improvement in SCI-DER total score (

P

= .02), in particular in dereal-

ization (

P

= .03) and autopsychic depersonalization (

P

= .04). Amean

weight gain of 4.8 kgwas observed. There is not significant different

related to the different affective temperament.

Discussion and conclusion

Analyses revealed a significant effect

of Quetiapine XR in improving impulsivity and dissociation, in

particular motor and attentional impulsiveness, derealization and

autopsychic depersonalization. Moreover, an improvement of dis-

sociative symptoms is probably connected with the blockade of

postsynaptic 5-HT1A receptors

[3] .

Methodological limitations,