European Psychiatry - Volume 33 - March 2016

380 / 812

S376 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
among all study group (n = 498) the depressed patients presented
higher proportion of rape history (25% vs. 9.5%, P = 0.001), of sui-
cide attempts (43.8% vs. 25%, P = 0.001) with only a trend of shorter
cumulative retention in MMT of mean 9.4y (95% CI 7.8–10.7) vs.
11.5 (95% CI 10.5–12.5, P = 0.07).
Conclusion Despite cocaine and benzodiazepine abuse on admis-
sion, depressed succeeded similarly to the non-depressed in the
first year retention in treatment. Intervention is recommended
since admission, as their long-term retention seems to be shorter,
later on, and their ability to discontinue cocaine and benzodi-
azepine abuse is clearly hampered.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV81
What triggers help-seeking behaviour
in “early stage” alcohol-dependent
drinkers
P. Ponizovskiy ∗, A. Gofman
Moscow Research Institute of Psychiatry, Department of mental
disorders complicated by substance abuse, Moscow, Russia
∗ Corresponding author.
Abstract In early stages of alcohol addiction negative effects of
alcohol often remain invisible to the patient or underestimated and
considered “normal” by him. However, there is a cohort of alcohol
drinkerswho seek outpatient treatment in early stages of addiction.
The study was conducted in order to investigate the triggers for
seeking therapy in early stages of alcohol dependence when com-
pulsive drinking, impaired control and increased alcohol tolerance
are developed, but withdrawal symptoms followed by relief drink-
ing are not yet observed. Fourty-six out-patients (31 men and 15
women, mean age 38 ± 7 years) were studied bymeans of audit and
clinical interview.
The average duration of alcohol abuse was 8,7 ± 5 years, the mean
daily dose of alcohol was 10 ± 4 standard drinks. Most of the
patients were drinking alcohol from several times a week to several
times a month.
The decision to seek treatment in most cases was pushed by
patients’ family members because of the recurrent interpersonal
problems caused or exacerbated by the effects of alcohol – 70%
(n = 32). Other triggers included: job instability – 35% (n = 16); alco-
hol blackouts – 26% (n = 12); exacerbations of symptoms of existing
physical conditions – 24% (n = 11); legal problems – 7% (n = 3).
Alcohol consumption in early stages of alcohol addiction can affect
nearly every aspect of a patient’s life. The triggers which promote
treatment-seeking behaviour should be addressed in the course of
the treatment in order to encourage recovery and prevent transi-
tion to more severe stages of the disease.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV82
Misuse of pregabalin: Case series and
literature review
N.E. Suardi , M. Preve ∗ Godio , E. Bolla , R.A. Colombo ,
R. Traber
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio,
Switzerland
∗ Corresponding author.
Introduction Pregabalin is widely used in neurology, psychiatry
and primary healthcare, and recently in literature different stud-
ies explain the possible misuse regabalin has shown greater
potency inpreclinicalmodels of epilepsy, pain and anxiety, andmay
have potential in the treatment of cocaine addiction he pur-
pose of this report is to review the clinical evidence for the potential
of abuse and misuse of pregabalin. We propose ten different cases
and literature review.
Method Ten inpatients with misuse of pregabalin were assessed
with: the SCID-P, Anamnestic Folio, HAM-A and DAST. We con-
ducted a systematic review of the literature (PubMed, Embase,
PsychInfo), using the terms “pregabalin”, “misuse”.
Results All our patients present: cocaine, alcohol and/heroin pos-
itive in drugs urine screening at admission; a significant high level
of total anxiety at the HAM-A Tot (P < .001), and especially at the
item 7 (P < .001); the misuse of pregabalin is made for sniffing;
the predominant symptoms assessed were euphoria, psychomotor
activation and sedation.
Discussion and conclusion Schifano F et al., uggest that
pregabalin should carefully prescribe in patients with a possible
previous history of drug abuse. Our result identifies a particular
population the misuse pregabalin that are abuser of cocaine, alco-
hol and/or heroin. Further research is warranted to replicate our
clinical and qualitative observations and, in general, quantitative
studies in large samples followed up over time are needed. Method-
ological limitations, clinical implications and suggestions for future
research directions are considered.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
References
[1] Schifano F. SSP 2014.
[2] Schifano F, et al. SSP 2011.
[3] de Guglielmo G, et al. SSP 2013.
EV83
Quetiapine XR reduce impulsivity and
dissociation in a sample of alcoholic
patients
M. Godio , M. Preve ∗ . Suardi , E. Bolla , R.A. Colombo ,
R. Traber
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio,
Switzerland
∗ Corresponding author.
Introduction Alcohol dependence (AD) is a major public health
problem. Currently, three drugs for the treatment of AD have been
approved: acamprosate, disulfiramand oral naltrexone. Quetiapine
XR is an atypical antipsychotic has been shown to be a promising
medication for the treatment of alcoholism The aim of our
study is evaluate quetiapine efficacy on impulsivity in a sample of
alcoholic patients.
Method A sample of alcoholic patients (n = 40) was assessed at
the entrance and 2 months with: SCID-P, Brief-Temps, BIS-11,
GSR, BPRS, SCI-DER, and CGI. The medium dosage of quetiapine
is 300mg.
Results Using the last observation carried forward, themean total
BIS score decreased from 60.8 at baseline to 40.2 at the final visit
(P = .03). More pronounced improvement was observed in motor
impulsiveness ( P < .03) and attentional impulsiveness (P < .05) com-
pared with non-planning impulsiveness (P = .09). We observed an
improvement in SCI-DER total score (P = .02), in particular in dereal-
ization (P= .03) and autopsychic depersonalization (P = .04). Amean
weight gain of 4.8 kgwas observed. There is not significant different
related to the different affective temperament.
Discussion and conclusion Analyses revealed a significant effect
of Quetiapine XR in improving impulsivity and dissociation, in
particular motor and attentional impulsiveness, derealization and
autopsychic depersonalization. Moreover, an improvement of dis-
sociative symptoms is probably connected with the blockade of
postsynaptic 5-HT1A receptors Methodological limitations,