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S94

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

FC53

Co-occurrence of PTSD and

cardiovascular disease among

ethnic/racial groups in the United

States

C. Vidal Mari˜no

1 ,

, R. Polo del Rio

1

, M. Alegría

2

, Y. Wang

2

,

R. Carmona

1

1

Fundación Jiménez Díaz, Departamento de Psiquiatría, Madrid,

Spain

2

Massachusetts General Hospital, Disparities Research Unit, Boston,

USA

Corresponding author.

Introduction

Some inconsistent evidence indicates experiences

of trauma and the presence of symptoms of PTSD are associated

with increased risk of cardiovascular diseases. This relation has

rarely been explored with community samples including partici-

pantswith PTSD symptoms orwho fulfill criteria for PTSDdisorders.

Objectives

We identify those with a high number of PTSD symp-

toms and those fulfilling criteria for PTSD are more likely to have

CVD than thosewithout a PTSD syndrome or

diagnosis.We

examine

rates of mental health access for those with PTSD and CVD.

Methods

We use Collaborative Psychiatric Epidemiology Surveys

(CPES) to examine differences in trauma/PTSD prevalence and the

association of prior trauma exposure and PTSD diagnoses with CVD

(

n

= 13,286). CIDI was used tomake psychiatric diagnoses andmed-

ical data was acquired regarding onset and severity of CVD.

Results

Individuals with prior exposure to trauma and PTSD diag-

noses had twice the likelihood of developing a cardiovascular

disease as those without trauma exposure [OR = 1.77, 95% CI (1.0,

2.94)]. Having a PTSD diagnosis is a significant predictor of having

a CVD for individuals who experienced a traumatic event.

The probability of developing a CVD was higher when patients had

prior diagnosis of substance abuse [OR = 1.36, 95% CI (1.11, 1.65)] or

mental health disorders [OR = 1.43, 95% CI (1.10, 1.87) for depres-

sion; OR = 1.33, 95% CI (1.04, 1.69) for anxiety]. Men were almost

twice as likely as women to be diagnosed with a CVD [OR = 1.67,

95% CI (1.37, 2.00)].

Conclusions

Exposure to trauma and the presence of PTSD symp-

toms are significantly associated with CVD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.057

Prevention of mental disorders

FC54

Prevalence of the metabolic syndrome

in patients at risk of psychosis

J. Cordes

1 ,

, A. Bechdolf

2

, S. Moebus

3

1

Medical Faculty, Düsseldorf, Germany

2

Klinik für Psychiatrie-Psychotherapie und Psychosomatik, Vivantes

Klinikum am Urban, Akademisches Lehrkrankenhaus, Berlin,

Germany

3

Zentrum Urbane Epidemiologie Cue, Universitätsklinikum Essen,

Universität Duisburg-Essen, Essen, Germany

Corresponding author.

Themetabolic syndrome (MetS) is one of themost frequent reasons

for the higher mortality in patients with schizophrenia. It is difficult

to separate between effects of medication or the disorder itself on

the development of MetS. In the present study, patients at clinical

high risk for first-episode psychosis (CHR) were examined and the

prevalence of the MetS was assessed. One hundred and sixty-three

unmedicated antipsychotic naïve CHR patients aged between 18

and 42 years and suffering from unmanifested prodromal symp-

toms were compared to 35,869 patients of the “German Metabolic

and Cardiovascular Risk Study” (GEMCAS). We observed a slightly

higher prevalence of single MetS criteria in CHR group compared

to the GEMCAS sample, in particular: high blood pressure (35.0

vs. 28.0%), waist circumference (17.6 vs. 15.1%), and high fasting

blood glucose (9.4 vs. 4.0%). We assume the higher risk for MetS

in schizophrenia patients or CHR patients to derive from genetic

factors.

Disclosure of interest

In cooperation with Joachim Cordes,

Andreas Bechdolf, Christina Engelke, Kahl KG, Chakrapani Bali-

jepalli, Christian Lösch, Joachim Klosterkötter, Michael Wagner,

Wolfgang Maier, Andreas Heinz, Walter de Millas, Wolfgang

Gaebel, Frank Schneider, Martin Lambert, Georg Juckel, Thomas

Wobrock, Michael Riedel, Susanne Moebus.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.058

Psychoneuroimmunology

FC55

Inflammatory cytokines and

glutaminergic excitotoxicity in

patients with obsessive-compulsive

disorder (OCD)

S. Gnanavel

1 ,

, A. Parmar

2

, P. Sharan

2

, V. Subbiah

3

, U. Sharma

4

,

N.R. Jagannathan

4

1

St Mary’s Hospital, CAMHS, Department of Psychiatry, Kettering,

United Kingdom

2

All India Institute of Medical Sciences, Psychiatry, New Delhi, India

3

All India Institute of Medical Sciences, Neurobiochemistry, New

Delhi, India

4

All India Institute of Medical Sciences, NMR and MRI Facility, New

Delhi, India

Corresponding author.

Introduction

In vitro studies have demonstrated possible neu-

roprotective effects of the following pro-inflammatory cytokines:

IL-6, IL-1 and TNF- against glutaminergic excitotoxicity in brain

through different pathways.

Objectives

In the current study, we aim to correlate level of the

above pro-inflammatory cytokines in serum with glutamate lev-

els in head of caudate nucleus measured using Proton Magnetic

Resonance Spectroscopy (

1

H-MRS) in patients with obsessive-

compulsive disorder (OCD), a neuropsychiatric illnesswith possible

multifactorial aetiology including immunological and excitotoxic

factors.

Method

Thirty psychotropic-naïve patients with OCD and an

equal number of gender and age-matched normal controls were

recruited in the study. A detailed psychiatric assessment was car-

ried out including sociodemographic and clinical variables. A 3T

MR imaging and spectroscopy session was carried out in head

of caudate nucleus. Further, absolute quantification of glutamate

level was obtained using LC model. Simultaneously, 5mL of blood

sample was collected and assayed for the above pro-inflammatory

cytokines (Siemens, Immulite

TM

). The level of glutamate was cor-

related with the cytokine levels in patients with OCD.

Results

The level of Glx was significantly higher in patients with

OCD as compared to controls (

P

< 0.05). The Glx level negatively

correlated with two of the three pro-inflammatory cytokines: IL-

6 and TNF- (

r

=

0.807;

r

=

0.838;

P

< 0.05) while no significant

correlation was demonstrated with IL-1 .

Conclusions

The findings provide preliminary evidence regarding

possible neuroprotective effects of pro-inflammatory cytokines