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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S89

Methods

Eighty-two MDD patients and 50 normal control (NC)

subjects participated in this study. We divided the MDD group into

unremitted and remitted group according to the reduction rate of

Hamilton Rating Scale for Depression (HAMD) within 2 weeks.

Results

The study detected significantly decreased VMHC in

bilateral precuneus (pCu), inferior temporal gyrus (ITG) and

increased VMHC inmiddle frontal gyrus (MFG) and caudate nucleus

when compared remitted depression (RD) group to unremit-

ted depression (URD) group. Meanwhile, when compared with

NC group, the URD group presented reduced VMHC in bilateral

cerebellum anterior lobe, thalamus and postcentral gyrus. Fur-

thermore, the VHMC in media frontal gyrus, postcentral gyrus

and precentral gyrus were significantly decreased in RD group.

Correlation analysis suggested that reduced VMHC in bilateral

pCu was negatively correlated with the baseline HAMD score of

URD (

r

=

0.325,

P

= 0.041). Receiver operating characteristic (ROC)

curve indicated that three regional VMHC changes could iden-

tify depressed patient with poorer treatment response: ITG [area

under curve (AUC) = 0.699,

P

= 0.002, 95% CI = 0.586–0.812], MFG

(AUC = 0.692,

P

= 0.003, 95% CI = 0.580–0.805), pCu (AUC = 0.714,

P

= 0.001, 95% CI = 0.603–0.825).

Conclusion

The current study combined with previous evidence

indicates that the subdued intrinsic interhemispheric functional

connectivity might represents a novel neural trait involved in the

pathophysiology of MDD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.048

FC45

Alteration in creatine phosphate

behavior in excited visual cortex of

early-stage schizophrenia patients

measured by phosphorus magnetic

resonance spectroscopy

A. Manzhurtsev

1 ,

, N .

Semenova

1 , 2 , 3 , M .

Ublinskiy

1 , 3 ,

T. Akhadov

3 , S. V

arfolomeev

1 , I. L

ebedeva

4 , V. K

aleda

4

1

Emanuel Institute of Biochemical Physics of Russian Academy of

Sciences, 501 Enzime catalysis kinetics, Moscow, Russia

2

Semenov Institute of Chemical Physics of Russian Academy of

Sciences, 0404 Chemical and biological processes dynamics, Moscow,

Russia

3

Research Institute of Children’s Emergency Surgery and Trauma,

Radiology, Moscow, Russia

4

Mental Health Research Center State Scientific Institution,

Neurovisualisation and Multimodal Analysis, Moscow, Russia

Corresponding author.

Introduction

31P MRS is a unique way of in vivo energy

metabolism research.

This method allowed revealing

schizophrenia-induced disturbances of energy exchange in

resting state

[1] . W

e use 31P MRS in presence of visual stimulation

that allows neuronal energy-consuming processes studying.

Objective

Revealing of stimulation effects on high-energy phos-

phates (PCr, ATP) in early-stage schizophrenia.

Aim

Discovery of energy processes contribution in schizophrenia

pathogenesis.

Methods

Twelve right-handed 18–26 years old male patients

with early-staged schizophrenia (F20, ICD-10) and 20 age-matched

healthy right-handed controls. Spectra were acquired on Philips

Achieva 3.0 T using Rapid Biomed 31P/1H birdcage coil and 2D ISIS

pulse sequence. fMRI was used for accurate 2D slice positioning,

spectroscopy voxels containing primary visual cortex (V1) were

averaged (see

Fig. 1 ).

Two 31P spectra of V1 were obtained: firstly

in resting state and then during 6minutes of continuous stimu-

lation by 6Hz flashing checkerboard. Spectra were processed in

jMRUI.

Results

Excitation reduced PCr in the norm and had no effect on

schizophrenia (see

Fig. 2 ).

No excitation-induced ATP changes in

both groups were revealed.

Conclusion

Alteration in PCr behavior in this study witnesses for

deviations in energy-consuming processes in schizophrenia. A new

scheme of neuronal response to stimulation in schizophrenia is

offered.

Fig. 1

fMRI-guided voxel positioning in visual cortex.

Fig. 2

PCr of visual cortex in the norm (1) and in schizophrenia

(2) during continuous stimulation relative to PCr in resting state. *

P

< 0.05 by Mann-Whitney U-criteria.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Reference

[1] Du F. JAMA Psychiatry 2014;71(1):19–27.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.049

FC46

Trimodal approach (PET/MR/EEG) of

response inhibition as a possible

biomarker for schizophrenia

C. Wyss

1 ,

, K. Heekeren

1

, A. Del Guerra

2

, N.J. Shah

3

,

I. Neuner

3 , 4

, K. Wolfram

1

1

University Hospital of Psychiatry Zurich, Department for Psychiatry,

Psychotherapy and Psychosomatics, Zurich, Switzerland

2

University of Pisa, Department of Physics “E. Fermi”, Pisa, Italy

3

Research Centre Jülich, Institute of Neuroscience and Medicine-

INM-4, Jülich, Germany