European Psychiatry - Volume 33 - March 2016

93 / 812

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S89
Methods Eighty-two MDD patients and 50 normal control (NC)
subjects participated in this study. We divided the MDD group into
unremitted and remitted group according to the reduction rate of
Hamilton Rating Scale for Depression (HAMD) within 2 weeks.
Results The study detected significantly decreased VMHC in
bilateral precuneus (pCu), inferior temporal gyrus (ITG) and
increased VMHC inmiddle frontal gyrus (MFG) and caudate nucleus
when compared remitted depression (RD) group to unremit-
ted depression (URD) group. Meanwhile, when compared with
NC group, the URD group presented reduced VMHC in bilateral
cerebellum anterior lobe, thalamus and postcentral gyrus. Fur-
thermore, the VHMC in media frontal gyrus, postcentral gyrus
and precentral gyrus were significantly decreased in RD group.
Correlation analysis suggested that reduced VMHC in bilateral
pCu was negatively correlated with the baseline HAMD score of
URD (r = −0.325, P= 0.041). Receiver operating characteristic (ROC)
curve indicated that three regional VMHC changes could iden-
tify depressed patient with poorer treatment response: ITG [area
under curve (AUC) = 0.699, P = 0.002, 95% CI = 0.586–0.812], MFG
(AUC = 0.692, P = 0.003, 95% CI = 0.580–0.805), pCu (AUC = 0.714,
P = 0.001, 95% CI = 0.603–0.825).
Conclusion The current study combined with previous evidence
indicates that the subdued intrinsic interhemispheric functional
connectivity might represents a novel neural trait involved in the
pathophysiology of MDD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC45
Alteration in creatine phosphate
behavior in excited visual cortex of
early-stage schizophrenia patients
measured by phosphorus magnetic
resonance spectroscopy
A. Manzhurtsev ∗ Semenova Ublinskiy
T. Akhadov arfolomeev ebedeva aleda
1 Emanuel Institute of Biochemical Physics of Russian Academy of
Sciences, 501 Enzime catalysis kinetics, Moscow, Russia
2 Semenov Institute of Chemical Physics of Russian Academy of
Sciences, 0404 Chemical and biological processes dynamics, Moscow,
Russia
3 Research Institute of Children’s Emergency Surgery and Trauma,
Radiology, Moscow, Russia
4 Mental Health Research Center State Scientific Institution,
Neurovisualisation and Multimodal Analysis, Moscow, Russia
∗ Corresponding author.
Introduction 31P MRS is a unique way of in vivo energy
metabolism research. This method allowed revealing
schizophrenia-induced disturbances of energy exchange in
resting state e use 31P MRS in presence of visual stimulation
that allows neuronal energy-consuming processes studying.
Objective Revealing of stimulation effects on high-energy phos-
phates (PCr, ATP) in early-stage schizophrenia.
Aim Discovery of energy processes contribution in schizophrenia
pathogenesis.
Methods Twelve right-handed 18–26 years old male patients
with early-staged schizophrenia (F20, ICD-10) and 20 age-matched
healthy right-handed controls. Spectra were acquired on Philips
Achieva 3.0 T using Rapid Biomed 31P/1H birdcage coil and 2D ISIS
pulse sequence. fMRI was used for accurate 2D slice positioning,
spectroscopy voxels containing primary visual cortex (V1) were
averaged (see Two 31P spectra of V1 were obtained: firstly
in resting state and then during 6minutes of continuous stimu-
lation by 6Hz flashing checkerboard. Spectra were processed in
jMRUI.
Results Excitation reduced PCr in the norm and had no effect on
schizophrenia (see No excitation-induced ATP changes in
both groups were revealed.
Conclusion Alteration in PCr behavior in this study witnesses for
deviations in energy-consuming processes in schizophrenia. A new
scheme of neuronal response to stimulation in schizophrenia is
offered.
Fig. 1 fMRI-guided voxel positioning in visual cortex.
Fig. 2 PCr of visual cortex in the norm (1) and in schizophrenia
(2) during continuous stimulation relative to PCr in resting state. *
P < 0.05 by Mann-Whitney U-criteria.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Reference
[1] Du F. JAMA Psychiatry 2014;71(1):19–27.
FC46
Trimodal approach (PET/MR/EEG) of
response inhibition as a possible
biomarker for schizophrenia
C. Wyss ∗, K. Heekeren , A. Del Guerra , N.J. Shah ,
I. Neuner , K. Wolfram
1 University Hospital of Psychiatry Zurich, Department for Psychiatry,
Psychotherapy and Psychosomatics, Zurich, Switzerland
2 University of Pisa, Department of Physics “E. Fermi”, Pisa, Italy
3 Research Centre Jülich, Institute of Neuroscience and Medicine-
INM-4, Jülich, Germany