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S88

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.045

Neuroimaging

FC42

Parkinsonism and basal ganglia

volumes in first-episode psychosis

M.J. Cuesta

1 , 2 ,

, A.M. Sánchez-Torres

1 , 2

, T. Cabada

2 , 3

,

P. Lecumberri

2 , 4

, R. Lorente-Ome˜naca

1 , 2

, J.M. López-Ilundain

1 , 2

,

M. Ribeiro

1 , 2

, L. Moreno-Izco

1 , 2

, M. Gómez

2 , 4

1

Complejo Hospitalario de Navarra, Department of Psychiatry,

Pamplona, Spain

2

IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

3

Complejo Hospitalario de Navarra, Department of Radiology,

Pamplona, Spain

4

Universidad Pública de Navarra, Department of Mathematics,

Pamplona, Spain

Corresponding author.

Introduction

Parkinsonian motor signs are the most frequent of

the genuine motor abnormalities present in drug-naïve patients

with schizophrenia, and are also present in patients with a first-

episode of psychosis (FEP).

Objective

To study whether there are differences in basal ganglia

volumes depending on the presence of Parkinsonism in FEP.

Methods

Forty-six patientswith a FEPwere included in the study.

Twenty-three controls were included to normalise patients’ brain

volume data. Parkinsonismwas assessed with the UKU scale. Brain

volumes were obtained with MRI (1.5 Tesla Siemens Avanto).

Reconstruction and volumetric segmentation was made with

the Freesurfer© software

( http://surfer.nmr.mgh.harvard.edu/

).

Patients were divided into two groups, considering the pres-

ence/absence of Parkinsonism (UKU total score cutoff point = 4).

Patients have been treatedwith antipsychotics amean of less than 2

months. Therewere not significant differences in the total exposure

to antipsychotics between both groups. ANCOVAS were performed

including gender as covariate.

Results

Patients with Parkinsonism showed a trend towards sig-

nificance to exhibit reduced volumes in the left caudate and right

putamen

( Fig. 1 ).

Conclusions

FEP patients who exhibit Parkinsonian signs tend to

show reduced left caudate and right putamen volumes in the early

phases of psychotic illness, after correcting by gender.

Fig. 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.046

FC43

The role of neurometabolites in

emotional processing

D. Denzel

1 ,

, L.R. Demenescu

2

, L. Colic

2

, F. von Düring

3

,

H. Nießen

3

, M. Walter

2

1

Magdeburg, Germany

2

Clinical Affective Neuroimaging Laboratory CANLAB, Leibniz

Institute for Neurobiology, Magdeburg, Germany

3

Clinical Affective Neuroimaging Laboratory CANLAB,

Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Corresponding author.

Objective

To investigate how brain metabolites, especially glu-

tamate and glutamate to glutamine ratio of pgACC modulate the

neural response within these areas and how this affects their func-

tion during emotion facial expression matching task.

Methods

Seventy healthy volunteers underwent magnetic reso-

nance spectroscopy (MRS) and task functional magnetic resonance

imaging (fMRI) in 7 Tesla scanner. PgACC MRS data were obtained

using STEAM sequence and analyzed using LCModel.

Angry, fearful, and happy facial expressions were presented in an

affect-matching block where one of the two facial expressions pre-

sented matched the target facial expression. The control condition

was form matching. Data were preprocessed and analyzed in SPM

8.

Results

Glutamate to Creatine ratiomeasured inpgACC positively

correlated with BOLD response in the right DLPFC during neg-

ative emotional perception (FWE = 0.05) Glutamate to glutamine

ratio indicating on-off mechanisms in pgACC positively corre-

lated with BOLD responses in FFA extending to cerebellum cluster

(FWE < 0.05).

Conclusion

This study indicate that pgACC, baseline metabolism

predicts neural response to emotional

processing.We

conclude that

individuals with higher glutamate ratios, an excitatory neurotrans-

mitter, in pgACC during rest might have a better copingmechanism

to potential danger indicated by perception of angry or afraid faces.

The higher glutamate to glutamine ratio in pgACC indicates a higher

turnover of excitatory metabolite glutamate. This mechanism is

associated with higher emotional response in fusiform area and

cerebellum suggesting higher visual attention towards negative

emotions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.047

FC44

Association analysis of imbalanced

interhemispheric functional

coordination and early therapeutic

efficacy in major depressive disorder:

Evidence from resting state fMRI

Z. Hou

1 ,

, X. Song

2

, W. Jiang

1

, Y. Yue

1

, Y. Yin

1

, Y. Zhang

1

,

Y. Liu

3

, Y. Yuan

1

1

Affiliated Zhongda Hospital of Southeast University, Medical School

of Southeast University, Department of Psychosomatics and

Psychiatry, Nanjing, China

2

College of Engineering, Peking University, Department of

Biomedical Engineering, Beijing, China

3

Key Laboratory of Cognition and Personality, Faculty of Psychology,

Southwest University, Chongqing, China

Corresponding author.

Introduction

Emerging evidences indicate that the alteration of

interhemispheric functional coordination may be involved in the

pathogenesis of major depressive disorder (MDD). In present study,

we aimto explore the potential marker by using the voxel-mirrored

homotopic connectivity (VMHC) approach, which may be con-

tributing to predict the clinical prognosis in MDD.