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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S85

a specific subgroup of depressed older patients, who need mul-

timodal treatment strategies integrating physical, cognitive, and

psychological functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.037

FC34

Association between physical frailty

and inflammation in late-life

depression

M. Arts

1 ,

, R . C

ollard

2 , H.

Comijs

3 , P. N

audé

4 , R. R

isselada

5 ,

P. Naarding

6

, R. Oude Voshaar

1

1

UMCG, Old Age Psychiatry, Groningen, Netherlands

2

UMC Radboud, Psychiatry, Nijmegen, Netherlands

3

VU University Medical Center/GGZInGeest, Psychiatry, Amsterdam,

Netherlands

4

UMCG, Neurology, Alzheimer Research Center, Groningen,

Netherlands

5

VNN, Psychiatry, Leeuwarden, Netherlands

6

GGNet, Old Age Psychiatry, Apeldoorn, Netherlands

Corresponding author.

Introduction

Although the criteria for physical frailty and depres-

sion partly overlap, both represent unique, but reciprocally related

constructs. The association between inflammation and frailty has

been reported consistently, in contrast to the association between

inflammation and late-life depression (LLD).

Aim and objectives

To determine whether physical frailty is asso-

ciated with low-grade inflammation in LLD.

Methods

The physical frailty phenotype, defined as three out

of five criteria (weight loss, weakness, exhaustion, slowness,

low physical activity level), and three inflammatory markers

[C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil

gelatinase–associated lipocalin (NGAL)] were assessed in a sample

of individuals aged 60 and older with depression according to Diag-

nostic and Statistical Manual of Mental Disorders, Fourth Edition,

criteria (

n

= 366).

Results

The physical frailty phenotype was not associated with

inflammatory markers in linear regression models adjusted for

sociodemographic characteristics, lifestyle characteristics, and

somaticmorbidity. Of the individual criteria, handgrip strengthwas

associated with CRP and IL-6, and gait speed was associated with

NGAL. Principal component analysis identified two dimensions

within the physical frailty phenotype: performance-based physi-

cal frailty (encompassing gait speed, handgrip strength, and low

physical activity) and vitality-based physical frailty (encompass-

ing weight loss and exhaustion). Only performance-based physical

frailty was associated with higher levels of inflammatory markers.

Conclusion

The physical frailty phenotype is not a unidimen-

sional construct in individuals with depression. Only performance-

based physical frailty is associated with low-grade inflammation in

LLD, which might point to a specific depressive subtype.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.038

FC35

Antidepressants and mortality risk in

a dementia cohort – data from

SveDem, the Swedish Dementia

Registry

D. Enache

1 ,

, S.M. Fereshtehnejad

2

, P. Cermakova

2

,

S. Garcia-Ptacek

2

, I. Kåreholt

2

, K. Johnell

2

, D. Religa

2

, V. Jelic

2

,

B. Winblad

2

, C. Ballard

3

, D. Aarsland

2

, J. Fastbom

2

,

M. Eriksdotter

2

1

Karolinska Institute, Stockholm, Sweden

2

Karolinska Institute, Department of Neurobiology, Care Sciences

and Society, Stockholm, Sweden

3

King’s College London, Wolfson Centre for Age-Related Diseases,

King’s College, London, United Kingdom

Corresponding author.

Background

The association between mortality risk and use of

antidepressants in people with dementia is unknown.

Objective

To describe the use of antidepressants in people with

different dementia diagnoses and to explore mortality risk asso-

ciated with use of antidepressants 3 years before a dementia

diagnosis.

Methods

Study population included 20,050 memory clinic

patients from Swedish Dementia Registry diagnosed with inci-

dent dementia. Data on antidepressants dispensed at the time of

dementia diagnosis and during three-year period before dementia

diagnosis was obtained from the Swedish Prescribed Drug Register.

Cox regression models were used.

Results

During a median follow-up of 2 years from dementia

diagnosis, 25.8% of dementia patients died. A quarter (25.0%) of

patients were on antidepressants at the time of dementia diag-

nosis while 21.6% used antidepressants at some point during a

three-year period before a dementia diagnosis. Use of antidepres-

sant treatment for 3 consecutive years before a dementia diagnosis

was associated with a lower mortality risk for all dementia dis-

orders (HR: 0.82, 95% CI: 0.72–0.94) and in Alzheimer’s disease

(HR: 0.61, 95% CI: 0.45–0.83). There were no significant associa-

tions between use of antidepressant treatment and mortality risk

in other dementia diagnoses.

Conclusion

Antidepressant treatment is common among patients

with dementia. Use of antidepressants during prodromal stages

may reduce mortality in dementia and specifically in Alzheimer’s

disease.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.039

FC36

Differential mortality rates in late-life

depression and subthreshold

depression: 10-year follow-up in the

community

C. Ho

1 ,

, T.P. Ng

2

1

Singapore, Singapore

2

National University of Singapore, Department of Psychological

Medicine, Singapore

Corresponding author.

Background

Although the association between depression and

excess mortality is well-established, effects of subthreshold

depression onmortality are

unclear.We

compared excessmortality

between threshold and subthreshold depression, and investigated

risks factors and disease-specific mortality rates according to the

depression threshold levels.

Methods

Cross-sectional and longitudinal analyses of data from

1070 participants aged 55 and above of the Singapore Longitudinal

Aging Study (SLAS). Baseline depression levels (Geriatric Mental

State Examination, GMS), chronic medical comorbidity, instru-

mental activities of daily living (IADL) were related to baseline

and 10-year follow-up of differential mortality rates according to

depression threshold level.

Results

The prevalence of late-life subthreshold and threshold

depression was 9.9% and 5.1%, respectively; 26.3% of respondents

died by the 10-year follow-up, with a mortality rate of 28.2 per

1000 person-years. The risk of mortality increased with age, male

gender, lower physical activity, multiplemedical comorbidities and

IADL-disability, but when stratified according to depression status,