European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S85
a specific subgroup of depressed older patients, who need mul-
timodal treatment strategies integrating physical, cognitive, and
psychological functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC34
Association between physical frailty
and inflammation in late-life
depression
M. Arts ∗ ollard Comijs audé isselada
P. Naarding , R. Oude Voshaar
1 UMCG, Old Age Psychiatry, Groningen, Netherlands
2 UMC Radboud, Psychiatry, Nijmegen, Netherlands
3 VU University Medical Center/GGZInGeest, Psychiatry, Amsterdam,
Netherlands
4 UMCG, Neurology, Alzheimer Research Center, Groningen,
Netherlands
5 VNN, Psychiatry, Leeuwarden, Netherlands
6 GGNet, Old Age Psychiatry, Apeldoorn, Netherlands
∗ Corresponding author.
Introduction Although the criteria for physical frailty and depres-
sion partly overlap, both represent unique, but reciprocally related
constructs. The association between inflammation and frailty has
been reported consistently, in contrast to the association between
inflammation and late-life depression (LLD).
Aim and objectives To determine whether physical frailty is asso-
ciated with low-grade inflammation in LLD.
Methods The physical frailty phenotype, defined as three out
of five criteria (weight loss, weakness, exhaustion, slowness,
low physical activity level), and three inflammatory markers
[C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil
gelatinase–associated lipocalin (NGAL)] were assessed in a sample
of individuals aged 60 and older with depression according to Diag-
nostic and Statistical Manual of Mental Disorders, Fourth Edition,
criteria (n = 366).
Results The physical frailty phenotype was not associated with
inflammatory markers in linear regression models adjusted for
sociodemographic characteristics, lifestyle characteristics, and
somaticmorbidity. Of the individual criteria, handgrip strengthwas
associated with CRP and IL-6, and gait speed was associated with
NGAL. Principal component analysis identified two dimensions
within the physical frailty phenotype: performance-based physi-
cal frailty (encompassing gait speed, handgrip strength, and low
physical activity) and vitality-based physical frailty (encompass-
ing weight loss and exhaustion). Only performance-based physical
frailty was associated with higher levels of inflammatory markers.
Conclusion The physical frailty phenotype is not a unidimen-
sional construct in individuals with depression. Only performance-
based physical frailty is associated with low-grade inflammation in
LLD, which might point to a specific depressive subtype.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC35
Antidepressants and mortality risk in
a dementia cohort – data from
SveDem, the Swedish Dementia
Registry
D. Enache ∗, S.M. Fereshtehnejad , P. Cermakova ,
S. Garcia-Ptacek , I. Kåreholt , K. Johnell , D. Religa , V. Jelic ,
B. Winblad , C. Ballard , D. Aarsland , J. Fastbom ,
M. Eriksdotter
1 Karolinska Institute, Stockholm, Sweden
2 Karolinska Institute, Department of Neurobiology, Care Sciences
and Society, Stockholm, Sweden
3 King’s College London, Wolfson Centre for Age-Related Diseases,
King’s College, London, United Kingdom
∗ Corresponding author.
Background The association between mortality risk and use of
antidepressants in people with dementia is unknown.
Objective To describe the use of antidepressants in people with
different dementia diagnoses and to explore mortality risk asso-
ciated with use of antidepressants 3 years before a dementia
diagnosis.
Methods Study population included 20,050 memory clinic
patients from Swedish Dementia Registry diagnosed with inci-
dent dementia. Data on antidepressants dispensed at the time of
dementia diagnosis and during three-year period before dementia
diagnosis was obtained from the Swedish Prescribed Drug Register.
Cox regression models were used.
Results During a median follow-up of 2 years from dementia
diagnosis, 25.8% of dementia patients died. A quarter (25.0%) of
patients were on antidepressants at the time of dementia diag-
nosis while 21.6% used antidepressants at some point during a
three-year period before a dementia diagnosis. Use of antidepres-
sant treatment for 3 consecutive years before a dementia diagnosis
was associated with a lower mortality risk for all dementia dis-
orders (HR: 0.82, 95% CI: 0.72–0.94) and in Alzheimer’s disease
(HR: 0.61, 95% CI: 0.45–0.83). There were no significant associa-
tions between use of antidepressant treatment and mortality risk
in other dementia diagnoses.
Conclusion Antidepressant treatment is common among patients
with dementia. Use of antidepressants during prodromal stages
may reduce mortality in dementia and specifically in Alzheimer’s
disease.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC36
Differential mortality rates in late-life
depression and subthreshold
depression: 10-year follow-up in the
community
C. Ho ∗, T.P. Ng
1 Singapore, Singapore
2 National University of Singapore, Department of Psychological
Medicine, Singapore
∗ Corresponding author.
Background Although the association between depression and
excess mortality is well-established, effects of subthreshold
depression onmortality are compared excessmortality
between threshold and subthreshold depression, and investigated
risks factors and disease-specific mortality rates according to the
depression threshold levels.
Methods Cross-sectional and longitudinal analyses of data from
1070 participants aged 55 and above of the Singapore Longitudinal
Aging Study (SLAS). Baseline depression levels (Geriatric Mental
State Examination, GMS), chronic medical comorbidity, instru-
mental activities of daily living (IADL) were related to baseline
and 10-year follow-up of differential mortality rates according to
depression threshold level.
Results The prevalence of late-life subthreshold and threshold
depression was 9.9% and 5.1%, respectively; 26.3% of respondents
died by the 10-year follow-up, with a mortality rate of 28.2 per
1000 person-years. The risk of mortality increased with age, male
gender, lower physical activity, multiplemedical comorbidities and
IADL-disability, but when stratified according to depression status,