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S80

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

Conclusions

Preliminary data from PNEI-MO Research Group

support the relationbetween systemic inflammation, psychological

status and development of precancerous colorectal cancer lesions.

Depression seems associated with the presence of colorectal ade-

nomas.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.024

Depression

FC21

Epigenetic signature of glucocorticoid

receptor is associated with the

familial component of depression:

A twin-based study

H. Palma-Gudiel , A. Cordova-Palomera , L. Marquès Feixa ,

F. Cirera Miquel , L. Fa˜nanás

University of Barcelona, Animal Biology, Barcelona, Spain

Corresponding author.

Introduction

Despite the fact that depression has an estimated

heritability around 40%, there is no definitive candidate gene con-

tributing to its etiology. The lack of an identified genetic component

for high-heritability disorders, like depression, gave rise to the

concept of missing heritability. The epigenetics’ field has pushed

forward new hypotheses to fill this gap since transgenerational

inheritance of epigenetic patterns has been described both in

animal models and, more recently, in humans. Depression is usu-

ally associated with an abnormal stress response and an altered

hypothalamic-pituitary-adrenal axis, regulated by the glucocorti-

coid receptor (coded by

NR3C1

gene). Therefore, NR3C1 has been

widely investigated as a functional candidate gene involved in

anxious-depressive spectrum disorders (ADSD) although a more

comprehensive study of its methylation is further required (Palma-

Gudiel et al., 2015).

Aims

To analyze NR3C1 promoter’s methylation and to study its

association with anxious-depressive spectrum disorders.

Methods

The sample consisted of 48 pairs of monozygotic twins,

from the UB twin register, grouped as concordant, discordant and

healthy pairs depending on whether both, one or none of the co-

twins of each pair were affected by a lifetime ADSD, according to

DSM-IV criteria (SCID). DNA methylation was assessed by bisulfite

conversion and subsequent pyrosequencing.

Results

Hypermethylation at specific CpG sites, not previously

reported, was detected in concordant twin pairs as compared with

discordant and healthy groups (

P

= 0.03).

Conclusions

The epigenetic pattern newly described in

NR3C1

gene may be contributing to the familial component of depres-

sion and thus could be putatively explained by transgenerational

inheritance of epigenetic phenomena.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.025

FC22

Pilot Project: Sound pillow treatment

to improve sleep quality for patients

with depression or bipolar diagnosis

with sleeping problems

H.N. Lund

, I.N. Pedersen

Aalborg Psychiatric Hospital, Klinik Syd, Aalborg, Denmark

Corresponding author.

A well-known symptom for patients with depression and bipolar

diagnosis is poor quality of sleep. This has a major impact on the

quality of life for the individual. Most recently, an article in the

Cochrane Review

, Music for insomnia in adults, concludes thatmusic

may be effective for improving sleepquality in adultswith insomnia

symptoms

[1] .

A Research Project at Aalborg University Hospital, Psychiatry, in

Denmark has been initiated involving psychiatrists and nurses

from an outpatient unit and researchers and music therapists from

the Music Therapy Research Clinic at the hospital in an innova-

tive collaboration. A pilot project is started, where patients with

depression are given a sound pillowwith special designed playlists,

offering selected calm music for the patients to use at home for

a period of 30 days. The listening periods are registered by the

patients. Questionnaires are filled out before and after the listening

period. A short semi-structured interview is taking place four times

throughout the listening period and as a follow-up, when patients

come in for control.

The aim is to investigate, whether music listening is helpful to

improve sleep quality and quality of life, and to investigate if music

listening can limit or replace medication. Discussion of first results.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Reference

[1] Jespersen, Koenig, Jennum, Vuust. Cochrane Rev 2015,

http://dx. doi.org/10.1002/14651858.CD010459.pub2

[Wiley & Sons Ltd.].

http://dx.doi.org/10.1016/j.eurpsy.2016.01.026

FC23

Sex differences in depressive

symptomatology in patients with

chronic hepatitis C during pegylated

interferon alpha therapy: A 72-week

prospective study

Z. Pavlovic

1 ,

, M .

Jasovic-Gasic

2 , D.

Delic

3 , N.

Maric

1 ,

O. Vukovic

4 , S. P

ejovic

5

1

School of Medicine, University of Belgrade, Clinic for Psychiatry,

Clinical Centre of Serbia, Belgrade, Serbia

2

School of Medicine, University of Belgrade, School of Medicine,

University of Belgrade, Belgrade, Serbia

3

School of Medicine, University of Belgrade, Institute of Infectious

and Tropical Diseases, Belgrade, Serbia

4

School of Medicine, University of Belgrade, Institute of Mental

Health, Belgrade, Serbia

5

Clinic for Psychiatry, Clinical Centre of Serbia, Clinic for Psychiatry,

Clinical Centre of Serbia, Belgrade, Serbia

Corresponding author.

Introduction

Treatment with pegylated interferon alpha (PEG-

IFN- ) is associated with depression more frequently in chronic

hepatitis C (CHC) patients than with other inflammatory diseases.

Objectives

To prospectively asses sex differences in the preva-

lence of depression in CHC patients during the PEG-IFN- , as well

as in the CHC group with no therapy.

Methods

Sample consisted of 103 subjects with CHC on the

PEG-IFN- and 103 subjects with CHC without interferon ther-

apy. The diagnosis of depressive disorder was established by using

Structured Clinical Interview and Criteria of International Classifi-

cation Disorder. The severity of depression was assessed by using

Hamilton Depression Rating Scale (HAMD

8) prior to PEG-IFN-

(baseline) and at the follow-up visits (4th, 12th, 24th, 48th, 72nd

week).

Results

During the course of PEG-IFN- , 49.5% of subjects showed

depressive symptomatology (HAMD

8). Except at baseline and

in the 72nd week, on the all other follow-up visits the preva-

lence of depression was significantly higher in female subjects

(*all

P

s < 0.05). The strongest difference was observed in the 12th

week: of all the subjects with HAMD

8, 68.8% were female and