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S78

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

Cognitive neuroscience

FC16

A novel protocol to assess dual task

cost as a potential measure of

cognitive reserve

A. Oliveira-Maia

1 ,

, I. Coelho

1

, J.B. Barahona-Corrêa

1

, V. Paixão

2

,

M. Camacho

1

, R.M. Costa

2

1

Champalimaud Clinical Centre, Champalimaud Centre for the

Unknown, Neuropsychiatry Unit, Lisbon, Portugal

2

Champalimaud Centre for the Unknown, Champalimaud Research,

Lisbon, Portugal

Corresponding author.

Introduction

Methods for measuring cognitive reserve (CR) are

limited and controversial. Dual task cost (DTC) paradigms, assessing

links between gait and cognition, are increasingly regarded as

robust measures of CR.

Objectives

Here, we aimed to validate a simplified methodology

for a DTC paradigm in healthy volunteers for application in clinical

settings as a measurement of CR.

Methods

We tested if subtracting by 7’s (cognitive task) while

walking (motor task) induced a DTC in a sample of 39 healthy young

adults. For the cognitive task, we recorded the number of correct

and incorrect subtractions, as well as the latency between subtrac-

tions. Gait parameters were recorded on a tri-axial accelerometer

fixed to the left ankle. Both tasks were performed separately (sin-

gle task) and simultaneously (double task) to assess the DTC. A

battery for neuropsychological assessment and questionnaires to

assess quality of life and affective symptoms were also applied, to

measure possible correlations with the DTC.

Results

Subtracting 7’s while walking caused significant changes

in gait parameters and in cognitive task performance. A significant

decrease in the autocorrelation of the accelerometer signal dur-

ing the dual task was also found (DTC = 37.92

±

7.56%;

P

< 0.0001).

This measure has not been previously used and may be a more

sensitive measure of the dual task induced disturbance of the gait

periodic signal pattern. Correlations between DTC and quality of

life, affective or cognitive measures were not significant.

Conclusion

Our study provides an effective, portable and non-

intrusive DTC experimental protocol that can be easily applied in

clinical settings.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.020

FC17

Cortisol, life events and cognition in

non-demented subjects: A

population-based study

S. Ouanes

, E. Castelao , A. Von Gunten , M. Preisig , J. Popp

CHUV, Department of Psychiatry, Lausanne, Switzerland

Corresponding author.

Background

Older people are particularly exposed to stress-

ful events, known to activate the hypothalamus-pituitary-adrenal

axis. Many studies highlighted the possible deleterious effects of

elevated cortisol on cognition, assuming a likely role of stressful

events. Yet, very fewstudies actually examined these assumed links

between life events, cortisol and cognition.

Objective

To examine associations between salivary cortisol,

cognition and life events in a population of non-demented old indi-

viduals.

Methods

A cross-sectional analysis was conducted using data

from Colaus/PsyColaus, a longitudinal population-based study

involving 6733 Lausanne residents. Salivary cortisol samples (upon

waking, 30minutes after waking, at 11 am and at 8 pm) were

obtained from 799 non-demented participants aged at least 60.

Life events, activities of daily life along with depressive symptoms

were assessed using a standardized questionnaire. A comprehen-

sive neuropsychological test battery was used to determine the

Clinical Dementia Rating (CDR).

For multiple comparisons,

P

values were adjusted (

P

) according to

Holm-Bonferroni’s method.

Results

Cortisol at 11 am and cortisol area under the curve (AUC)

were positively correlated with CDR sum of boxes (CDRSOB) scores

(

P

= 0.035; Rho = 0.097 and

P

= 0.024; Rho = 0.110, respectively).

The association between cortisol AUC and CDRSOB remained sig-

nificant after controlling for age, sex, body mass index, education,

smoking and depression (

P

= 0.001; = 0.001; R

2

change = 0.016).

The number and the total impact of life events were associated

neither with cortisol nor with CDRSOB.

Conclusions

Elevated cortisol was associated with poorer cogni-

tive functioning yet independently of life events. This suggests that

the increased cortisol associated with poorer cognition might be

not a mere reflection of stressful events but rather explained by

other factors, yet to be elucidated.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.021

FC18

The EVACO Project: A new battery for

assessing social cognition disorders

and related psychiatric disability in

schizophrenia

P. Roux

1 ,

, M. Urbach

1

, S. Fonteneau

1

, B. Aouizerate

1 , 3 , 4 , 5 , 6 , 7 , 8

,

F. Berna

1 , 6 , 7 , 8

, L. Brunel

1 , 9

, D. Capdevielle

1 , 10

, I. Chereau

1 , 11

,

J. Danion

1 , 7

, J. Dorey

1 , 12

, C. Dubertret

1 , 13

, J. Dubreucq

1 , 14

,

C. Faget

1 , 15 , F.

Gabayet

1 , 14 , P.

M. Llorca

1 , 11 , J.

Mallet

1 , 13 ,

D. Misdrahi

1 , 3 , 4 , 5 , 6 , 7 , 8 , 1 6 , R .

Rey

1 , 12 , R .

Richieri

1 , 15 ,

F. Schürhoff

1 , 9 , H .

Yazbek

1 , 10 , C .

Passerieux

1 , 2 ,

E. Brunet-Gouet

1 , 2 , FA C

E-SCZ-Grou

p 16

1

Fondation FondaMental, Créteil, France

2

Service de psychiatrie d’adulte, Centre Hospitalier de Versailles, UFR

des Sciences de la Santé Simone Veil, Université Versailles

Saint-Quentin-en-Yvelines, Versailles, France

3

Centre Hospitalier Charles-Perrens, 33076 Bordeaux, France

4

Université de Bordeaux, Bordeaux, France

5

Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité

Neuronale, U862, 33000 Bordeaux, France

6

Hôpitaux Universitaires de Strasbourg, Université de Strasbourg,

Inserm U1114, Fédération de Médecine Translationnelle de

Strasbourg, Strasbourg, France

7

Inserm U955, Translational Psychiatry team, Créteil, France

8

Paris Est University, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux

Universitaires H.-Mondor, Créteil, France

9

Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière,

CHRU de Montpellier, Université Montpellier 1, Inserm 1061,

Montpellier, France

10

CMP B, CHU, EA 7280 Faculté de Médecine, Université d’Auvergne,

BP 69, 63003 Clermont-Ferrand cedex 1, France

11

Université Claude-Bernard Lyon 1, Centre Hospitalier Le Vinatier

Pole Est, BP 300, 39–95, boulevard Pinel, 69678 Bron cedex, France

12

AP–HP, Department of Psychiatry, Louis-Mourier Hospital, Inserm

U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de

médecine, Colombes, France

13

Centre Référent de Réhabilitation Psychosociale, Centre Hospitalier

Alpes Isère, Grenoble, France

14

Assistance publique des Hôpitaux de Marseille (AP–HM), pôle

universitaire de psychiatrie, Marseille, France

15

CNRS UMR 5287-INCIA, France