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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S79

16

FondaMental Academic Centers of Expertise for Schizophrenia

(FACE-SZ) group, France

Corresponding author.

The relation of social cognitive disorders and schizophrenic symp-

toms are well-established. Yet, assessment methods have not

reached a consensus. In addition, causal paths betweenneurocogni-

tion, social cognition, symptoms and functional expression are not

clearly understood. During the past few years, some authoritative

accounts proposed specialized batteries of tests and emphasized

theory of mind, emotion recognition, and interpretation bias con-

structs:

– NIMH’s “Social cognition psychometric evaluation” battery

(PinkhamAE, Penn DL, GreenMF, Harvey PD.

Schizophrenia Bulletin

,

2015);

– “Social cognition and functioning in schizophrenia” (Green MF,

Lee J, Ochsner KN.

Schizophrenia Bulletin

, 2013).

Interestingly, these accounts stemming either from expert con-

sensus and psychometric considerations or from neuroscience

knowledge recognized some difficulties in providing a fully usable

set of instruments. The project described here (EVACO proto-

col, funded by the Programme Hospitalier de Recherche Clinique

national) follows an alternative approach and aims at providing

a psychometrically validated battery. Based on a cognitive neu-

ropsychology view on schizophrenic functional disability, several

tests were gathered and are assessed in a 12-months multi-center

follow-up of 160 individuals with schizophrenia. The FondaMen-

tal foundation network of Expert Centers is involved in recruiting

patients from eight centers (Clermont-Ferrand, Colombes, Créteil,

Grenoble, Marseille, Montpellier, Strasbourg, Versailles). To-date,

the first evaluation of the population has been achieved. Experience

reports and inclusions follow-up demonstrate the good acceptabil-

ity of this battery both on the patients and the evaluator’s side.

We emphasize the usefulness of this project to meet the clinicians’

needs of validated social cognition tools, by describing different

scenarios of use.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.022

FC19

The relationship between premorbid

adjustment and cognitive dysfunction

in schizophrenia

P. Stefanatou

1 ,

, C.S. Karatosidi (MSc)

2

, E. Kattoulas

1

,

N. Stefanis

1

, N. Smyrnis

1

1

Eginition Hospital, Medical School, University of Athens, 1st

Department of Psychiatry, Athens, Greece

2

Eginition Hospital, Medical School, University of Athens, Clinical

Neuropsychology, Athens, Greece

Corresponding author.

Introduction

Premorbid adjustment (PA) is one of the main

prognostic indicators of schizophrenia. Both social and cognitive

deficits observed during the premorbid period hold a predictive

value for the onset of schizophrenia.

Objectives

To investigate how cognitive functions are related to

aspects of PA.

Aims

To examine the relationship of each PA domain (academic

and social) at each of the three developmental stages (childhood,

early adolescence and late adolescence), aswell as their coursewith

the cognitive functions in schizophrenia patients.

Methods

PA, intellectual quotient (IQ), verbal learning, mem-

ory, processing speed, executive functions and verbal fluency were

assessed using PAS, WAIS, RAVLT, TMT, WCST and COWAT meas-

ures respectively in a sample of 85 clinically stabilized male

schizophrenia inpatients.

Results

Negative correlations emerged between academic PA

during adolescence and both verbal IQ and processing speed, while

positive correlations were found with working memory. Negative

correlations emerged between deterioration in academic PA dur-

ing adolescence and both processing speed and immediate auditory

verbal recall, while correlations with verbal learning were positive.

There was no relationship between cognitive functions and either

social PA or its deterioration.

Conclusion

Our findings revealed significant associations

between both academic PA and its course with cognitive functions

in schizophrenia patients. In summary, deficits in several fields

of cognitive functions seem to follow a different path long before

and after the onset of the disease, but further investigation is

necessary.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.023

Comorbidity/dual pathologies

FC20

Role of metabolic, atherogenetic and

psychological factors in patients with

colorectal adenomas: Preliminary

results of the psycho-Neuro-

Endocrino-Immunology Modena

(PNEI-MO) Research Group

S. Ferrari

1

, S. Mancini

1

, S. Alboni

1

, C. Artoni

1

, A. Fabbrizzi

1

,

L. Feltri

1

, G. Galli

1

, A. Guicciardi

1

, M. Marchi

1

, F. Mariani

1

,

G. Mattei

1 ,

, G. Pollutri

1

, S. Saraceni

1

, P. Sena

1

, G. Spiga

1

,

S. Tassi

1

, C. Visentini

1

, L. Roncucci

1

, A. Merighi

2

, M. Marsico

2

1

University of Modena and Reggio Emilia, Department of

Clinical-Diagnostic Medicine and Public Health, Modena, Italy

2

Policlinico Hospital, Endoscopy Unit, Modena, Italy

Corresponding author.

Introduction

Pro-inflammatory states of the large bowel have

a multifactorial aetiology, including metabolism, atherogenesis,

and psychological determinants. Inflammation plays a role in

depressive and anxiety disorders, is tightly associated with early

pro-atherogenetic alterations and metabolic dysregulation, and is

also a key factor for the development of colorectal cancer.

Aim

To investigate the association between pro-atherogenetic

factors, metabolic status, psychological assessment and presence

of colorectal adenomas.

Methods

Case-control study, approved by the local Ethic Com-

mittee. Patients aged 40 or more and undergoing colonoscopy

for positive faecal blood test and/or abdominal symptoms, with

a negative history for neoplasia or inflammatory bowel dis-

eases, were enrolled. For each patient the following data were

collected: waist and hip circumferences, BMI, arterial pressure,

fasten serum glycemia, current medications. Beside colonoscopy,

carotid intima-media thickness (IMT) was assessed by means

of echographic evaluation. Psychometric assessment included

HADS, TCI, IMSA, SF-36. Statistics performed with SigmaPlot v.12

Platform.

Results

Preliminary results are available for 18 patients

(male/female 8/10) Mean age 62.6

±

8.4. Ten patients had at

least one adenoma, 8 patients had no lesions. The following differ-

ences were noticeable: HADS-depression (mean

±

SD) adenoma

vs. no-adenoma: 4.9

±

3.2 vs. 1.7

±

1.8 (

P

< .01); IMT median value

adenoma vs. no-adenoma: 793 vs. 638 micrometers (

P

= .04); Body

weight (mean

±

SD) adenoma vs. no-adenoma: 66.4

±

8.7 kg vs.

80.9

±

15.3 kg (

P

= .03); waist circumference (mean

±

SD) adenoma

vs. no-adenoma: 105.2

±

13.4 cm vs. 89.5

±

4.7 cm (

P

< .01).