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S82

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.030

FC27

The prevalence and correlates of

haematological abnormalities in adult

inpatients with anorexia nervosa

C. Hopkins

1 ,

, A . B

runo

2 , P. J

enkins

2 , A. A

yton

2

1

Berkshire Healthcare NHS Foundation Trust, Prospect Park Hospital,

Reading, United Kingdom

2

Oxford Healthcare NHS Foundation Trust, Cotswold House, Oxford,

United Kingdom

Corresponding author.

Introduction

There is only limited literature concerning haema-

tological abnormalities in anorexia nervosa (AN), with little past

investigation into these abnormalities in adult AN patients admit-

ted to inpatient eating disorder (ED) units.

Objectives

This study sought to determine the prevalence and

severity of haematological abnormalities in admitted AN patients,

and to examine correlates of these abnormalities.

Methods

All adult patients with a clinical diagnosis of AN admit-

ted to the Cotswold House specialist ED inpatient unit between

November 2013 and December 2014 were included in the study.

Demographic, anthropometric and haematological parameters

were systematically recorded for the duration of each admission.

The proportions of patients affected by haematological abnormali-

ties (anaemia, leucocytopaenia, neutropaenia, thrombocytopaenia

and pancytopaenia) were selected as primary outcomes, and binary

logistic regression was performed using SPSS 22.0.

Results

A total of 37 AN patients (91.9% female; mean age: 29.7

years) were included in this study, with a mean admission BMI of

13.7 kg/m

2

(SD: 1.8) and a mean admission duration of 128 days;

54.1% of patients were anaemic, 64.9% of patients experienced leu-

cocytopaenia, 56.8% of patients developed neutropaenia, 16.2% of

patients suffered thrombocytopaenia, and 8.1% of patients were

pancytopaenic. Logistic regression identified low admission BMI

(

P

= 0.009) and low serum albumin level (

P

= 0.017) as significant

correlates of anaemia, and isolated increased age (

P

= 0.034) as a

significant associate of leucocytopaenia.

Conclusions

Haematological abnormalities occur frequently in

AN inpatients. Given the frequency at which abnormalities

occurred in this cohort, further large-scale and prospective studies

examining haematological abnormalities in inpatient AN popula-

tions are warranted.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.031

Epidemiology and social psychiatry

FC28

A multi-attribute utility instrument

suitable for use in individuals with

psychosis – the AQoL-4D: Findings

from the Second Australian National

Survey of Psychosis

A. Neil

1 ,

, V. Carr

2 , 3

, A. Mackinnon

4

, A. Waterreus

5

, H. Stain

6

,

M.C. Hanlon

7 , 8 , 9

, S. Korn (Consultant, Epidemiologist)

10

,

V. Morgan

5

1

University of Tasmania, Menzies Institute of Medical Research,

Hobart, Australia

2

University of New South Wales, Research Unit for Schizophrenia

Epidemiology. School of Psychiatry, Sydney, Australia

3

Monash University, Department of Psychiatry, Melbourne, Australia

4

The University of Melbourne, Orygen Youth Health Research Centre,

Melbourne, Australia

5

University of Western Australia, Neuropsychiatric Epidemiology

Research Unit. School of Psychiatry and Clinical Neurosciences, Perth,

Australia

6

Durham University, Wolfson Research Institute for Health and

Well-being, Stockton-On-Tees, United Kingdom

7

The University of Newcastle, Centre for Brain and Mental Health

Research, Newcastle, Australia

8

Calvary Mater Newcastle, Radiation Oncology/Physics, Newcastle,

Australia

9

Hunter Medical Research Institute, Brain and Mental Health

Program, Newcastle, Australia

10

Melbourne, Australia

Corresponding author.

Introduction

Multi-attribute utility instruments (MAUIs) are

generic health-related quality of life (HRQoL) measures that enable

valuation of health states relative to death (0.0) and full health

(1.0). The usefulness of MAUIs in people with psychosis has been

questioned, with the EQ-5D considered “insensitive”, the 15D

“problematic” and the SF-6D “unsuitable”.

Objectives

Confirm the Assessment of Quality of Life (AQoL)-4D

MAUI is useful and meaningful in people with psychosis.

Aims

Assess utility values across demographic, general and

disease-specific health categorisations for a large nationally-

representative sample with psychosis (

n

= 1825).

Methods

Participants underwent a comprehensive 32 module

interview encompassing psychopathology to service use. Util-

ity values were calculated by applying a standard algorithm to

responses to each of 12 items of the AQoL-4D.

Results

Utility values were assessed for 1793 participants

(98.2%). No ceiling effect was observed and only 6.6% of partici-

pants scored in the top decile of HRQoL [0.9–10.0]. In contrast, 10.8%

scored in the lowest decile [

0.04–0.10], a floor effect observed in

0.4%. The mean utility value was 0.49 (95% CI: 0.48–0.51), signif-

icantly lower than the Australian population norm of 0.81 (95%

CI: 0.81–0.82). Greatest impacts on HRQoL were for diminishing

global independent functioning as measured by the MSIF (ES

MSIF

:

0.68–2.24), self-rated current mental health (ES

MH

: 0.15–1.65)

and physical health status (ES

PH

: 0.11–1.21). Strong effects also

observed for course of disorder (ES

CoD

: 0.08–1.13), current suicidal

ideation (ES

CSI1

: 0.76–1.08), and labor force participation (ES

LFP

:

0.11–0.97).

Conclusions

The AQoL-4D had good lower end sensitivity in a

large sample of people with a psychotic illness, and demonstrated

responsiveness across subjective, objective and symptom meas-

ures.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.032

FC29

Loneliness is adversely associated

with lifestyle and physical and mental

health

A. Richard

1 ,

, S . R

ohrmann

1 , C.L

. Vandeleur

2 , M.

Schmid

1 ,

M. Eichholzer

1

1

Epidemiology-Biostatistics and Prevention Institute EBPI, University

of Zurich, Chronic Disease Epidemiology, Zurich, Switzerland

2

Centre for Research in Psychiatric Epidemiology and

Psychopathology, University Hospital of Lausanne, Department of

Psychiatry, Prilly, Switzerland

Corresponding author.