European Psychiatry - Volume 33 - March 2016

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S82 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC27
The prevalence and correlates of
haematological abnormalities in adult
inpatients with anorexia nervosa
C. Hopkins ∗ runo enkins yton
1 Berkshire Healthcare NHS Foundation Trust, Prospect Park Hospital,
Reading, United Kingdom
2 Oxford Healthcare NHS Foundation Trust, Cotswold House, Oxford,
United Kingdom
∗ Corresponding author.
Introduction There is only limited literature concerning haema-
tological abnormalities in anorexia nervosa (AN), with little past
investigation into these abnormalities in adult AN patients admit-
ted to inpatient eating disorder (ED) units.
Objectives This study sought to determine the prevalence and
severity of haematological abnormalities in admitted AN patients,
and to examine correlates of these abnormalities.
Methods All adult patients with a clinical diagnosis of AN admit-
ted to the Cotswold House specialist ED inpatient unit between
November 2013 and December 2014 were included in the study.
Demographic, anthropometric and haematological parameters
were systematically recorded for the duration of each admission.
The proportions of patients affected by haematological abnormali-
ties (anaemia, leucocytopaenia, neutropaenia, thrombocytopaenia
and pancytopaenia) were selected as primary outcomes, and binary
logistic regression was performed using SPSS 22.0.
Results A total of 37 AN patients (91.9% female; mean age: 29.7
years) were included in this study, with a mean admission BMI of
13.7 kg/m2 (SD: 1.8) and a mean admission duration of 128 days;
54.1% of patients were anaemic, 64.9% of patients experienced leu-
cocytopaenia, 56.8% of patients developed neutropaenia, 16.2% of
patients suffered thrombocytopaenia, and 8.1% of patients were
pancytopaenic. Logistic regression identified low admission BMI
(P = 0.009) and low serum albumin level (P= 0.017) as significant
correlates of anaemia, and isolated increased age (P = 0.034) as a
significant associate of leucocytopaenia.
Conclusions Haematological abnormalities occur frequently in
AN inpatients. Given the frequency at which abnormalities
occurred in this cohort, further large-scale and prospective studies
examining haematological abnormalities in inpatient AN popula-
tions are warranted.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Epidemiology and social psychiatry
FC28
A multi-attribute utility instrument
suitable for use in individuals with
psychosis – the AQoL-4D: Findings
from the Second Australian National
Survey of Psychosis
A. Neil ∗, V. Carr , A. Mackinnon , A. Waterreus , H. Stain ,
M.C. Hanlon , S. Korn (Consultant, Epidemiologist) ,
V. Morgan
1 University of Tasmania, Menzies Institute of Medical Research,
Hobart, Australia
2 University of New South Wales, Research Unit for Schizophrenia
Epidemiology. School of Psychiatry, Sydney, Australia
3 Monash University, Department of Psychiatry, Melbourne, Australia
4 The University of Melbourne, Orygen Youth Health Research Centre,
Melbourne, Australia
5 University of Western Australia, Neuropsychiatric Epidemiology
Research Unit. School of Psychiatry and Clinical Neurosciences, Perth,
Australia
6 Durham University, Wolfson Research Institute for Health and
Well-being, Stockton-On-Tees, United Kingdom
7 The University of Newcastle, Centre for Brain and Mental Health
Research, Newcastle, Australia
8 Calvary Mater Newcastle, Radiation Oncology/Physics, Newcastle,
Australia
9 Hunter Medical Research Institute, Brain and Mental Health
Program, Newcastle, Australia
10 Melbourne, Australia
∗ Corresponding author.
Introduction Multi-attribute utility instruments (MAUIs) are
generic health-related quality of life (HRQoL) measures that enable
valuation of health states relative to death (0.0) and full health
(1.0). The usefulness of MAUIs in people with psychosis has been
questioned, with the EQ-5D considered “insensitive”, the 15D
“problematic” and the SF-6D “unsuitable”.
Objectives Confirm the Assessment of Quality of Life (AQoL)-4D
MAUI is useful and meaningful in people with psychosis.
Aims Assess utility values across demographic, general and
disease-specific health categorisations for a large nationally-
representative sample with psychosis (n = 1825).
Methods Participants underwent a comprehensive 32 module
interview encompassing psychopathology to service use. Util-
ity values were calculated by applying a standard algorithm to
responses to each of 12 items of the AQoL-4D.
Results Utility values were assessed for 1793 participants
(98.2%). No ceiling effect was observed and only 6.6% of partici-
pants scored in the top decile of HRQoL [0.9–10.0]. In contrast, 10.8%
scored in the lowest decile [ −0.04–0.10], a floor effect observed in
0.4%. The mean utility value was 0.49 (95% CI: 0.48–0.51), signif-
icantly lower than the Australian population norm of 0.81 (95%
CI: 0.81–0.82). Greatest impacts on HRQoL were for diminishing
global independent functioning as measured by the MSIF (ESMSIF :
0.68–2.24), self-rated current mental health (ES MH : 0.15–1.65)
and physical health status (ESPH: 0.11–1.21). Strong effects also
observed for course of disorder (ESCoD: 0.08–1.13), current suicidal
ideation (ESCSI1: 0.76–1.08), and labor force participation (ESLFP :
0.11–0.97).
Conclusions The AQoL-4D had good lower end sensitivity in a
large sample of people with a psychotic illness, and demonstrated
responsiveness across subjective, objective and symptom meas-
ures.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC29
Loneliness is adversely associated
with lifestyle and physical and mental
health
A. Richard ∗ ohrmann . Vandeleur Schmid
M. Eichholzer
1 Epidemiology-Biostatistics and Prevention Institute EBPI, University
of Zurich, Chronic Disease Epidemiology, Zurich, Switzerland
2 Centre for Research in Psychiatric Epidemiology and
Psychopathology, University Hospital of Lausanne, Department of
Psychiatry, Prilly, Switzerland
∗ Corresponding author.