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S86

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

none of the variables was statistically significant for the subthres-

hold depression group. Depression, regardless of threshold levels,

increased mortality risk by at least 1.6 folds, with small difference

between the two. Cardiovascular mortality risk was significantly

increased by 2.17 fold (

P

= 0.024) in threshold but not subthreshold

depression.

Conclusion

Both subthreshold and threshold depression increase

the risk of excess mortality, though it is slightly higher when

reaches threshold levels. Subthreshold depression should be

regarded as part of the depressive illness spectrum and more

emphasis on recognition and timely treatment of this disorder

should be considered in clinical practice.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.040

FC37

Premorbid personality characteristics

and CSF markers of Alzheimer’s

pathology

D. Kukreja

1 ,

, D. Tautvydaité

1

, J.P. Antoinetti

2

, H. Henry

3

,

A. von Gunten

1

, J. Popp

1

1

University Hospital of Lausanne, Psychiatry Old age Psychiatry

SUPAA-Cery, Lausanne, Switzerland

2

University of Lausanne, Statistics, Lausanne, Switzerland

3

University Hospital of Lausanne, Psychiatry, Lausanne, Switzerland

Corresponding author.

Background

Beginning as early as in young adulthood, person-

ality characteristics may contribute to cognitive reserve by their

influence on lifestyle and health-related behavior. A “resilient”

personality profile may be associated with less cognitive and func-

tional impairment in persons with cerebral Alzheimer’s disease

(AD) pathology.

Aim

The aim of this study was to investigate whether premor-

bid personality characteristics modulate the relationships between

cognitive performance and AD pathology as measured using CSF

biomarkers at preclinical and early clinical disease stages.

Subjects and methods

Sixty-eight patients with mild cognitive

impairment or mild dementia and forty-two older subjects with

normal cognition have been included. Premorbid personality char-

acteristics were assessed by the NEO Personality Inventory Revised

(as reported by a close relative) along with cognitive perfor-

mance, functional status and CSF concentrations of A 1-42, tau,

and ptau181.

Multivariate regression analysis, including age, gender, education

years, and APOEe4 genotype was used to evaluate associations

between disease severity and premorbid personality scores, and

the CSF markers of AD pathology.

Results

Overall, therewere significant associations between Clin-

ical dementia rating-Sum of boxes (CDRSOB) and the interactions

of each personality trait with the ptau181/A 1-42 ratio. In subjects

with cognitive impairment, there were significant associations

between CDRSOB and the interactions of ptau181/A 1-42 ratio

with Neuroticism, Extraversion, Openness and Conscientiousness.

Significant results were also found using the interaction between

different personality traits and the tau/A 1-42 to predict the CDR-

SOB.

Discussion

The findings suggest that premorbid personality char-

acteristics modify the relationship between cerebral pathology and

cognitive performance at very early clinical stages of AD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.041

FC38

Validity of the Geriatric Depression

Scale-30 against the gold standard

diagnosis of depression in older age:

The GreatAGE Study

M. Lozupone

1 ,

, F. Veneziani

1

, I. Galizia

1

, L. Lofano

1

,

D. Montalbò

1

, S. Arcuti

2

, R. Tortelli

2

, M.R. Barulli

2

, R. Capozzo

2

,

C. Bonfiglio

3

, F. Panza

2

, D. Seripa

4

, O. Todarello

1

, G. Logroscino

2

1

Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense

Organs, University of Bari Aldo Moro, Bari, Italy

2

Pia Fondazione “Cardinale G. Panico”, Tricase, Department of

Clinical Research in Neurology, University of Bari Aldo Moro, Tricase

LE, Italy

3

IRCCS “S. De Bellis”, Epidemiology and Biostatistics Laboratory,

Castellana Grotte BA, Italy

4

Geriatric Unit & Laboratory of Gerontology and Geriatrics,

Department of Medical Sciences, IRCCS “Casa Sollievo della

Sofferenza”, San Giovanni Rotondo FG, Italy

Corresponding author.

Introduction

Depression is a common disorder in late-life. Struc-

tured clinical interviews may be less efficient compared to

self-administered questionnaires, but provide more accurate find-

ings in terms of diagnosis. No population-based studies with both

these depression assessment instruments have been ever per-

formed.

Objectives

To estimate the GDS-30 accuracy for depression

assessment against the gold standard [Semi-structured Clini-

cal Diagnostic Interview for DSM-IV-TR Axis I Disorders (SCID)]

in subjects 65+ years in a random sampling of the general

population.

Methods

The sample was collected in a population-based study

(GreatAGE) conducted among elderly residents in Castellana,

Southeast Italy. It includes 597 participants (57.62% males, mean

age 73 years). Depressionwas assessed through the GDS-30 and the

SCID, both double-blinded administered respectively by a trained

neuropsychologist and psychiatrist. The GDS-30 screening per-

formances were analyzed using ROC curves.

Results

According to the gold standard SCID, the rate of depres-

sive disorder was 10.22% (15.81% of women; 6.1% of men) while

withGDS-30 instrument 12.06% of the residentsmet the depression

cutoff. Only 36.1% of GDS cases were true positive. At the optimal

cutoff score (> 5), GDS had 62% sensitivity and 81% specificity. Using

amore conservative cutoff (> 9), the GDS-30 specificity reached 91%

while sensitivity dropped to 43%.

Conclusions

These preliminary results from the first population-

based study that compares GDS-30 and SCID showed that the

GDS-30 identified adequate levels of screening accuracy (AUC 0.76)

compatible with scores established in community settings.

Funding

PRIN2009E4RM4Z.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.042

FC39

Specific personality changes in

subjects with MCI and mild dementia

are associated with cerebral

Alzheimer’s pathology as measured by

CSF biomarkers

D. Tautvydait ˙e

1 ,

, J. P.

Antonietti

2 , A. V

on Gunten

1 , H.

Henry

3 ,

J. Popp

1

1

Lausanne University Hospital, CHUV, Service of Old Age Psychiatry,

Department of Psychiatry, Lausanne, Switzerland

2

University of Lausanne, Faculty of Social and Political Sciences,

Institute of Psychology, Lausanne, Switzerland