European Psychiatry - Volume 33 - March 2016

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S86 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115
none of the variables was statistically significant for the subthres-
hold depression group. Depression, regardless of threshold levels,
increased mortality risk by at least 1.6 folds, with small difference
between the two. Cardiovascular mortality risk was significantly
increased by 2.17 fold (P = 0.024) in threshold but not subthreshold
depression.
Conclusion Both subthreshold and threshold depression increase
the risk of excess mortality, though it is slightly higher when
reaches threshold levels. Subthreshold depression should be
regarded as part of the depressive illness spectrum and more
emphasis on recognition and timely treatment of this disorder
should be considered in clinical practice.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC37
Premorbid personality characteristics
and CSF markers of Alzheimer’s
pathology
D. Kukreja ∗, D. Tautvydaité , J.P. Antoinetti , H. Henry ,
A. von Gunten , J. Popp
1 University Hospital of Lausanne, Psychiatry Old age Psychiatry
SUPAA-Cery, Lausanne, Switzerland
2 University of Lausanne, Statistics, Lausanne, Switzerland
3 University Hospital of Lausanne, Psychiatry, Lausanne, Switzerland
∗ Corresponding author.
Background Beginning as early as in young adulthood, person-
ality characteristics may contribute to cognitive reserve by their
influence on lifestyle and health-related behavior. A “resilient”
personality profile may be associated with less cognitive and func-
tional impairment in persons with cerebral Alzheimer’s disease
(AD) pathology.
Aim The aim of this study was to investigate whether premor-
bid personality characteristics modulate the relationships between
cognitive performance and AD pathology as measured using CSF
biomarkers at preclinical and early clinical disease stages.
Subjects and methods Sixty-eight patients with mild cognitive
impairment or mild dementia and forty-two older subjects with
normal cognition have been included. Premorbid personality char-
acteristics were assessed by the NEO Personality Inventory Revised
(as reported by a close relative) along with cognitive perfor-
mance, functional status and CSF concentrations of A 1-42, tau,
and ptau181.
Multivariate regression analysis, including age, gender, education
years, and APOEe4 genotype was used to evaluate associations
between disease severity and premorbid personality scores, and
the CSF markers of AD pathology.
Results Overall, therewere significant associations between Clin-
ical dementia rating-Sum of boxes (CDRSOB) and the interactions
of each personality trait with the ptau181/A 1-42 ratio. In subjects
with cognitive impairment, there were significant associations
between CDRSOB and the interactions of ptau181/A 1-42 ratio
with Neuroticism, Extraversion, Openness and Conscientiousness.
Significant results were also found using the interaction between
different personality traits and the tau/A 1-42 to predict the CDR-
SOB.
Discussion The findings suggest that premorbid personality char-
acteristics modify the relationship between cerebral pathology and
cognitive performance at very early clinical stages of AD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC38
Validity of the Geriatric Depression
Scale-30 against the gold standard
diagnosis of depression in older age:
The GreatAGE Study
M. Lozupone ∗, F. Veneziani , I. Galizia , L. Lofano ,
D. Montalbò , S. Arcuti , R. Tortelli , M.R. Barulli , R. Capozzo ,
C. Bonfiglio , F. Panza , D. Seripa , O. Todarello , G. Logroscino
1 Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense
Organs, University of Bari Aldo Moro, Bari, Italy
2 Pia Fondazione “Cardinale G. Panico”, Tricase, Department of
Clinical Research in Neurology, University of Bari Aldo Moro, Tricase
LE, Italy
3 IRCCS “S. De Bellis”, Epidemiology and Biostatistics Laboratory,
Castellana Grotte BA, Italy
4 Geriatric Unit & Laboratory of Gerontology and Geriatrics,
Department of Medical Sciences, IRCCS “Casa Sollievo della
Sofferenza”, San Giovanni Rotondo FG, Italy
∗ Corresponding author.
Introduction Depression is a common disorder in late-life. Struc-
tured clinical interviews may be less efficient compared to
self-administered questionnaires, but provide more accurate find-
ings in terms of diagnosis. No population-based studies with both
these depression assessment instruments have been ever per-
formed.
Objectives To estimate the GDS-30 accuracy for depression
assessment against the gold standard [Semi-structured Clini-
cal Diagnostic Interview for DSM-IV-TR Axis I Disorders (SCID)]
in subjects 65+ years in a random sampling of the general
population.
Methods The sample was collected in a population-based study
(GreatAGE) conducted among elderly residents in Castellana,
Southeast Italy. It includes 597 participants (57.62% males, mean
age 73 years). Depressionwas assessed through the GDS-30 and the
SCID, both double-blinded administered respectively by a trained
neuropsychologist and psychiatrist. The GDS-30 screening per-
formances were analyzed using ROC curves.
Results According to the gold standard SCID, the rate of depres-
sive disorder was 10.22% (15.81% of women; 6.1% of men) while
withGDS-30 instrument 12.06% of the residentsmet the depression
cutoff. Only 36.1% of GDS cases were true positive. At the optimal
cutoff score (> 5), GDS had 62% sensitivity and 81% specificity. Using
amore conservative cutoff (> 9), the GDS-30 specificity reached 91%
while sensitivity dropped to 43%.
Conclusions These preliminary results from the first population-
based study that compares GDS-30 and SCID showed that the
GDS-30 identified adequate levels of screening accuracy (AUC 0.76)
compatible with scores established in community settings.
Funding PRIN2009E4RM4Z.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC39
Specific personality changes in
subjects with MCI and mild dementia
are associated with cerebral
Alzheimer’s pathology as measured by
CSF biomarkers
D. Tautvydait ˙e ∗ Antonietti on Gunten Henry
J. Popp
1 Lausanne University Hospital, CHUV, Service of Old Age Psychiatry,
Department of Psychiatry, Lausanne, Switzerland
2 University of Lausanne, Faculty of Social and Political Sciences,
Institute of Psychology, Lausanne, Switzerland