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S84

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

possibly due to the medium to low compatibility between datasets

( Fig. 1 ).

Conclusion

Early promising results suggest that increased knowl-

edge of G

×

E interactions could be achieved if studies increased

uniformity of measuring ED and environmental variables, allowing

for continued collaboration to overcome the restrictions of obtain-

ing genetic samples.

Fig. 1

The interaction between 5-HTTLPR (s-allele present ver-

sus s-allele absent) and number of traumatic life events to predict

likelihood of an eating disorder in females.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.035

Geriatric psychiatry

FC32

A quality improvement intervention

in geriatric psychiatry care: Results of

a pre-post design study

E. Albuquerque

, S. F

ernandes , J. Cerejeira

Coimbra Hospital and Universitary Centre, Psychiatry, Coimbra,

Portugal

Corresponding author.

Introduction

Innovative approaches are needed to respond to

the increasing number of elderly subjects with complex psychi-

atric conditions who require flexible and rapid responses, avoiding

unnecessary hospital admissions. A new organizational model was

implemented in our psychogeriatric service in September 2011

consisting of:

– a comprehensive multidisciplinary geriatric assessment;

– a helpline for caregivers for management of acute behavioral

problems;

– programmed visits to nursing homes.

Aims

To evaluate whether the implementation of this program

was associated with a reduction in hospital admissions and emer-

gency department visits.

Methods

This is a pre-post test design study, involving 1197

patients who attended the Old Age Psychiatric (OAP) Unit three

years before and three years after the implementation of the

organizational intervention (1.09.2008 to 1.10.2014). An index of

patient

×

year was calculated considering the period during which

the patient was followed in OAP Unit. Data was obtained from the

medical files of all eligible patients regarding demographic vari-

ables, number and type of hospital admissions and emergency

department visits.

Results

During the 3 years before the intervention 671.2

patients

×

years were included (mean age of 75.8 years) while after

the intervention this reached 2010.1 patients

×

years (mean age

of 77.8 years). The intervention was associated with a decrease

of 44% in psychiatry emergency visits, 48% in general emergency

visits, 44% in psychiatric ward admissions and 51% in geriatric ward

admissions.

Conclusions

The implementation of this new model was associ-

atedwith significant reduction of hospital-based service utilization.

Future research should determine if this was coupled with

increased health outcomes.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.036

FC33

Association between physical frailty

and cognition in late-life depression

M. Arts

1 ,

, R. Collard

2

, H. Comijs

3

, M. Zuidersma

4

, S. de Rooij

5

,

P. Naarding

6

, R. Oude Voshaar

1

1

UMCG, Old Age Psychiatry, Groningen, Netherlands

2

Radboud UMC, Clinical Psychiatry, Nijmegen, Netherlands

3

VU University Medical Center/GGZinGeest, Psychiatry, Amsterdam,

Netherlands

4

UMCG, University Center for Psychiatry, Groningen, Netherlands

5

UMCG, Clinical Geriatrics, Groningen, Netherlands

6

GGNet, Old Age Psychiatry, Apeldoorn, Netherlands

Corresponding author.

Introduction

Cognitive frailty has recently been defined as the co-

occurrence of physical frailty and cognitive impairment. Late-life

depression is associated with both physical frailty and cognitive

impairment, especially processing speed and executive function-

ing.

Aim and objectives

In this study, we investigated the association

between physical frailty and cognitive functioning in depressed

older persons.

Methods

In a total of 378 patients (> 60 years) with depression

according to DSM-IV criteria and a MMSE score of 24 points or

higher, the physical frailty phenotype as well as its individual crite-

ria (weight loss, weakness, exhaustion, slowness, low activity) was

studied. Cognitive functioning was examined in 4 domains: ver-

balmemory, workingmemory, interference control, andprocessing

speed.

Results

Of the 378 depressed patients (range 60–90 years; 66.1%

women), 61 were classified as robust (no frailty criteria present),

214 as prefrail (1 or 2 frailty criteria present), and 103 as frail

(> 3 criteria). Linear regression analyses, adjusted for confounders,

showed that the severity of physical frailty was associated with

poorer verbal memory, slower processing speed, and decreased

working memory, but not with changes in interference control.

Conclusion

In late-life depression, physical frailty is associated

with poorer cognitive functioning, although not consistently for

executive functioning. Future studies should examinewhether cog-

nitive impairment in the presence of physical frailty belongs to

cognitive frailty and is indeed an important concept to identify