European Psychiatry - Volume 33 - March 2016

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S84 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115
possibly due to the medium to low compatibility between datasets
Conclusion Early promising results suggest that increased knowl-
edge of G × E interactions could be achieved if studies increased
uniformity of measuring ED and environmental variables, allowing
for continued collaboration to overcome the restrictions of obtain-
ing genetic samples.
Fig. 1 The interaction between 5-HTTLPR (s-allele present ver-
sus s-allele absent) and number of traumatic life events to predict
likelihood of an eating disorder in females.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Geriatric psychiatry
FC32
A quality improvement intervention
in geriatric psychiatry care: Results of
a pre-post design study
E. Albuquerque ∗ ernandes , J. Cerejeira
Coimbra Hospital and Universitary Centre, Psychiatry, Coimbra,
Portugal
∗ Corresponding author.
Introduction Innovative approaches are needed to respond to
the increasing number of elderly subjects with complex psychi-
atric conditions who require flexible and rapid responses, avoiding
unnecessary hospital admissions. A new organizational model was
implemented in our psychogeriatric service in September 2011
consisting of:
– a comprehensive multidisciplinary geriatric assessment;
– a helpline for caregivers for management of acute behavioral
problems;
– programmed visits to nursing homes.
Aims To evaluate whether the implementation of this program
was associated with a reduction in hospital admissions and emer-
gency department visits.
Methods This is a pre-post test design study, involving 1197
patients who attended the Old Age Psychiatric (OAP) Unit three
years before and three years after the implementation of the
organizational intervention (1.09.2008 to 1.10.2014). An index of
patient ×year was calculated considering the period during which
the patient was followed in OAP Unit. Data was obtained from the
medical files of all eligible patients regarding demographic vari-
ables, number and type of hospital admissions and emergency
department visits.
Results During the 3 years before the intervention 671.2
patients × years were included (mean age of 75.8 years) while after
the intervention this reached 2010.1 patients× years (mean age
of 77.8 years). The intervention was associated with a decrease
of 44% in psychiatry emergency visits, 48% in general emergency
visits, 44% in psychiatric ward admissions and 51% in geriatric ward
admissions.
Conclusions The implementation of this new model was associ-
atedwith significant reduction of hospital-based service utilization.
Future research should determine if this was coupled with
increased health outcomes.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC33
Association between physical frailty
and cognition in late-life depression
M. Arts ∗, R. Collard , H. Comijs , M. Zuidersma , S. de Rooij ,
P. Naarding , R. Oude Voshaar
1 UMCG, Old Age Psychiatry, Groningen, Netherlands
2 Radboud UMC, Clinical Psychiatry, Nijmegen, Netherlands
3 VU University Medical Center/GGZinGeest, Psychiatry, Amsterdam,
Netherlands
4 UMCG, University Center for Psychiatry, Groningen, Netherlands
5 UMCG, Clinical Geriatrics, Groningen, Netherlands
6 GGNet, Old Age Psychiatry, Apeldoorn, Netherlands
∗ Corresponding author.
Introduction Cognitive frailty has recently been defined as the co-
occurrence of physical frailty and cognitive impairment. Late-life
depression is associated with both physical frailty and cognitive
impairment, especially processing speed and executive function-
ing.
Aim and objectives In this study, we investigated the association
between physical frailty and cognitive functioning in depressed
older persons.
Methods In a total of 378 patients (> 60 years) with depression
according to DSM-IV criteria and a MMSE score of 24 points or
higher, the physical frailty phenotype as well as its individual crite-
ria (weight loss, weakness, exhaustion, slowness, low activity) was
studied. Cognitive functioning was examined in 4 domains: ver-
balmemory, workingmemory, interference control, andprocessing
speed.
Results Of the 378 depressed patients (range 60–90 years; 66.1%
women), 61 were classified as robust (no frailty criteria present),
214 as prefrail (1 or 2 frailty criteria present), and 103 as frail
(> 3 criteria). Linear regression analyses, adjusted for confounders,
showed that the severity of physical frailty was associated with
poorer verbal memory, slower processing speed, and decreased
working memory, but not with changes in interference control.
Conclusion In late-life depression, physical frailty is associated
with poorer cognitive functioning, although not consistently for
executive functioning. Future studies should examinewhether cog-
nitive impairment in the presence of physical frailty belongs to
cognitive frailty and is indeed an important concept to identify