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S90

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

4

RWTH Aachen University, Department of Psychiatry, Psychotherapy

and Psychosomatics, Aachen, Germany

Corresponding author.

Introduction

The aim of the FP7-European funded project TRIM-

AGE is to create a trimodal, cost-effective imaging tool consisting

of PET/MR/EEG to enable effective early diagnosis of schizophrenia.

Objective

In the scope of this project we are interested in

the multimodal assessment of response inhibition. The loudness

dependence of auditory evoked potential (LDAEP) is a suitable

biomarker of inhibitory action in signal processing. Variations in

response inhibition can have great impact on different aspects of

life. Individuals with reduced capability of inhibitory control have

a tendency to impulsive behavior. Studies showed that they have

stronger LDAEP values. Patients with schizophrenia may exhibit

alterations in the responsiveness to sensory stimuli. Thus, a reduced

LDAEP was found in these patients. However, these deviances dif-

fered in clinical features of the disorder. Therefore, we would like to

further elucidate the relationship betweenmultimodal neuroimag-

ing methods and dimensions of symptoms, observable behavior,

personality traits and general psychopathological dysfunction.

Methods

A sample of 20 healthy controls and 20 patients with

manifest schizophrenia will be examinedwith the LDAEP paradigm

in a trimodal approachwith customary imaging tools. PETmeasure-

ments with the radiotracer [11C]-flumazenil will be used to assess

the binding potentials of GABA-A receptors. MRS will provide data

about GABA concentrations. Simultaneously recorded EEG-fMRI

data will permit new insight in the relationship between LDAEP

and impulsivity.

Discussion

The project will use alternative approaches to psy-

chiatric classification. Response inhibition in sensory processing

will be investigated from different angles (biochemical, neuro-

physiological, and neuroanatomical) and combined with psycho-

logical characteristic values.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.050

FC47

A diffusion tensor imaging study of

white matter microstructure

concerning suicidal ideation in major

depressive disorder

H. Zhang

1 ,

, Z. Jia

2

1

West China Hospital, Sichuan University, Radiology, Chengdu, China

2

West China Hospital, Sichuan University, Nuclear medicine,

Chengdu, China

Corresponding author.

Introduction

Suicide is a serious public health problem.

Microstructural abnormalities of white matter (WM) in major

depressive disorder (MDD) patients had been studied with diffu-

sion tensor image (DTI) before. However, little is known regarding

suicidal ideation (SI).

Objectives

To use diffusion tensor imaging to characterize abnor-

malities of white matter integrity in major depressive disorder

patients with and without SI.

Methods

Sixteen depressive patients with SI, 16 depressive

patients without SI and 32 age- and gender-matched healthy con-

trols received MRI scans on a 3T magnet. Whole brain voxel-based

analysis was used to compare fractional anisotropy (FA) across the

three groupswith threshold at

P

< 0.005 (uncorrected) at voxel level

and 50 for cluster size with SPM8. Pearson analyze was conducted

to examine the association between clinical measurements and

regional FA value.

Results

The three groups had significant differences of FA in the

left centrum semiovale (peak Z = 4.64 at

30,

38, 34), right cen-

trum semiovale (peak Z = 3.54 at 32,

34, 32) and right splenium of

corpus callosum (peak Z = 4.64 at 4,

34, 12;

Fig. 1 ).

We also found a

negative correlation between mean regional FA values in the white

matter under the left centrum semiovale and the intensity of sui-

cidal ideation scores (

r

=

0.563,

P

= 0.023).

Conclusion

Suicidal ideation is associated with microstructure

abnormalities of thewhitematter in centrumsemiovale and corpus

callosum.

Fig. 1

Brain regions differed significantly among groups. A. Bilat-

eral centrum semiovale. B. Right splenium of corpus callosum.

C. Patients tested.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.051

Obsessive-compulsive disorder

FC48

Actions speak louder than words:

Enhanced action tendencies in

obsessive-compulsive disorder:

An ERP study

A. Dayan Riva

1 ,

, A. Berger

2

, G. Anholt

2

1

Beer Sheva, Israel

2

Ben Gurion University of the Negev, Psychology, Beer Sheva, Israel

Corresponding author.

Obsessive-compulsive disorder (OCD) is characterized by repeated

thoughts and behaviors. Several studies have detected defi-

cient response inhibition ability in individuals with OCD, leading

researchers to suggest this deficit as an endophenotype of OCD.