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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S91

However, other researchers maintain that the effect size of this

deficit is modest and that it lacks clinical significance. The cur-

rent investigation examines a potential alternative explanation for

difficulties in response inhibition, namely enhanced action ten-

dencies in response to stimuli. Therefore, early processes of motor

response preparation preceding action performance (or inhibition)

were studied with the event-related potential (ERP) component

of readiness potential (RP). RP measures brain reactions related to

motor activity in response to external stimuli. ERPs were recorded

while 15 participants with OCD and 16 healthy controls performed

a variation of a go/no-go task and a stop-signal task using schematic

faces (angry and neutral). The OCD group presented with a greater

RP slope gradient and amplitude over bilateral parietal areas cor-

responding to the motor cortex. The amplitude effect was further

enhanced under negative valence, compared with the neutral con-

dition. Differences in RP between the OCD and control groups

remained significant when controlling for levels of trait anxiety.

Results support the hypothesis that a stronger readiness for action

might characterize OCD, especially in the presence of threatening

stimuli. This finding, specific to OCD and not to anxiety symptoms,

may underlie habitual tendencies in OCD. This study suggests that

early-stages of motor preparation might be important to the etiol-

ogy and maintenance of OCD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.052

Pain and treatment options

FC49

The net suppression effect of pain

catastrophic cognition on anxiety

sensitivity

W. Wong

1 ,

, J. L

am

2 , H.

Lim

3 , S. W

ong

4 , P. C

hen

5 , Y. C

how

4 ,

R. Fielding

6

1

Hong Kong Institute of Education, Department of Special Education

& Counseling, Hong Kong, China

2

Hong Kong Institute of Education, Department of Psychological

Studies, Hong Kong, China

3

United Christian Hospital, Department of Anesthesiology, Pain

Medicine & Operating Services, Hong Kong, China

4

Queen Mary Hospital, Department of Anesthesiology & Operating

Services, Hong Kong, China

5

Alice Ho Miu Ling Nethersole Hospital, Department of

Anesthesiology & Operating Services, Hong Kong, China

6

University of Hong Kong, School of Public Health, Hong Kong, China

Corresponding author.

Introduction

The existing literature on chronic pain points to

the effects anxiety sensitivity, pain hypervigilance, and pain

catastrophizing on pain-related fear; however, the nature of the

relationships remains unclear. The three dispositional factors may

affect one another in the prediction of pain adjustment out-

comes. The addition of one dispositionmay increase the association

between another disposition and outcomes, a consequence known

as suppressor effects in statistical terms.

Objective

This study examined the possible statistical suppressor

effects of anxiety sensitivity, pain hypervigilance and pain catastro-

phizing in predicting pain-related fear and adjustment outcomes

(disability and depression).

Methods

Chinese patients with chronic musculoskeletal pain

(

n

= 401) completed a battery of assessments on pain intensity,

depression, anxiety sensitivity, pain vigilance, pain catastrophiz-

ing, and pain-related fear. Multiple regression analyses assessed

the mediating/moderating role of pain hypervigilance. Structural

equationmodeling (SEM) was used to evaluate suppression effects.

Results

Our results evidenced pain hypervigilance mediated the

effects of anxiety sensitivity (Model 1: Sobel z = 4.86) and pain

catastrophizing (Model 3: Sobel z = 5.08) on pain-related fear. Net

suppression effect of pain catastrophizing on anxiety sensitivity

was found in SEM where both anxiety sensitivity and pain catas-

trophizingwere included in the same fullmodel to predict disability

(Model 9: CFI = 0.95) and depression (Model 10: CFI = 0.93) (all

P

< 0.001) (see

Tables 1 and 2 , F igs. 1 and 2 ).

Conclusions

Our findings evidenced that pain hypervigilance

mediated the relationship of two dispositional factors, pain cata-

strophic cognition and anxiety sensitivity, with pain-related fear.

The net suppression effects of pain catastrophizing suggest that

anxiety sensitivity enhanced the effect of pain catastrophic cogni-

tion on pain hypervigilance.

Table 1

Multivariate regression analyses of the relationships

between pain hypervigilance, anxiety sensitivity, pain-related fear.

Table 2

Results of SEM testing the relationships between anxiety

sensitivity, pain catastrophizing, and pain hypervigilance for two

pain adjustment outcomes.