European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S93
Background Cluster B personality disorder (PD) is a highly preva-
lent mental health condition in general population (1 to 6%
depending on the subtype and study). Patients affected are known
to be heavier users of both mental and medical healthcare than
other clinical conditions such as depression. Few studies have
highlighted their elevated mortality rate compared to general pop-
ulation.
Methods The estimates were produced using data from the inte-
gratedmonitoring system for chronic disease of Quebec. It provides
annual and life prevalence, mortality rate, years of and healthcare
utilization profile Quebec inhabitants.
Results A total of 7,995,963 people were included in the study.
The life prevalence of cluster B PD is 2.6%. The mean years of lost
life is 13 for men and 9 for women when they are compared to gen-
eral population. The 3 most important causes of death are: suicide
(20.4%), cardiovascular diseases (19.1%) and cancers (18.6%). The
standardized mortality ratio (SMR) for each medical condition is
superior in cluster B personality disorders than general population.
The most important SMR is for suicide (male: 10.2 and female: 21).
In the year 2011–2012, 78% had consulted a general practitioner,
62% a psychiatrist, 41%were admitted in an emergency department
and 21% were hospitalized.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC51
Correlation between attachment and
personality dimensions and their
association to the
catechol-O-methyltransferase
Val158Met polimorphism
L. Erkoreka ∗, M.I. Macías , A. Arrue , N. Basterreche ,
A. Arnaiz ordo Olivas antos I. Zamalloa
M. Zumárraga . González-Torres
1 Mental Health Network of Biscay, Centro Salud Mental Barakaldo,
Barakaldo, Spain
2 Mental Health Network of Biscay, Hospital de Zamudio, Zamudio,
Spain
3 Mental Health Network of Biscay, Centro Salud Mental Gernika,
Gernika, Spain
4 Universidad del País Vasco, Neurociencias, Leioa, Spain
5 Hospital Universitario de Basurto, Servicio de Psiquiatría, Bilbao,
Spain
∗ Corresponding author.
Introduction Both attachment style and personality traits are
closely related to individual’s interpersonal patterns. Association
between these constructs has been widely studied, but variability
in results makes it difficult to reach definite conclusions. Similarly,
dopaminergic pathways are considered to underlie some person-
ality traits and to be related to attachment styles, but evidence,
hitherto, remain inconclusive.
Aims To assess the correlation between personality and attach-
ment dimensions and to study whether a common association
to the catechol-O-methyltransferase (COMT) Val158Met polymor-
phism exists.
Methods One hundred and three Caucasian controls (mean age
39.6 ±6.4; 65% women) were recruited in the province of Bis-
cay, Spain. DAPP-BQ and ECR-Spanish scales were administered to
assess personality and attachment dimensions respectively. DNA
was obtained from saliva and the COMT Val158Met polymorphism
was determined. Pearson’s correlation coefficient and ANOVAwere
calculated using R statistical software.
Results High positive correlation is observed between inhibi-
tion personality dimension and attachment avoidance (r = 0.75).
Besides, both inhibition and avoidance dimensions’ scores are
significantly higher in the COMT ValMet genotype than in the
other genotypes. MetMet: 63.1± 13.6; ValMet: 71.0± 13.9; ValVal:
63.0± 16.7 (ANOVA F = 3.75, P = 0.027) for inhibition and Met-
Met: 3.44 ±0.17; ValMet: 3.82 ±0.2; ValVal: 3.33 ±0.23 (ANOVA
F = 3.83, P= 0.025) for avoidance.
Conclusions Attachment patterns are rooted in early interactions
with parental figures, and according to our results they could
be linked to self-perceived personality traits in adulthood. Our
study also suggests that genetics may predispose individuals to
certain interaction styles. Our findings, linking ValMet individuals
to avoidant attachment, are similar to Luijk’s (2011) results, and
would support a genetic-environmental model of both attachment
and personality.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Posttraumatic stress disorder
FC52
Traumatic stress and risk of severe
mental illness: A nationwide cohort
study
N. Okkels ∗, B. Trabjerg , M. Arendt , C. Bøcker Pedersen
1 Department of Affective Disorders, Aarhus University Hospital
Risskov, Risskov, Denmark
2 Clinic for Anxiety Disorders, Aarhus University Hospital Risskov,
Risskov, Denmark
3 National Centre for Register-Based Research, Aarhus University,
Aarhus, Denmark
∗ Corresponding author.
Introduction A history of traumatic events is prevalent in peo-
ple with schizophrenia spectrum disorders and mood disorders.
However, little is known about their etiological relationship.
Objectives To explore whether patients with acute or post-
traumatic stress disorder are at higher risk of developing a
schizophrenia spectrum disorder or mood disorder.
Methods In this prospective cohort study using registers covering
the entire Danish population, we used the Danish Psychiatric Cen-
tral Research Register to identify patients with ICD-10 diagnoses of
acute traumatic stress disorder and/or posttraumatic stress disor-
der. From inpatient and outpatient mental hospitals, we identified
4371 diagnoses withmore than 18 million years of follow-up. Main
outcomes and measures were relative risks (RR) with 95% confi-
dence intervals (95% CI) of schizophrenia, schizophrenia spectrum
disorder, bipolar disorder and mood disorder.
Results The incidence of traumatic stress disorder (TSD) has
increased steadily from0.6% in 1996 to 6% in 2012, showed a higher
incidence in women and an age distribution with a peak-incidence
in early adulthood. We found that diagnoses of TSD increase the risk
of schizophrenia (RR 5.85, 95% CI 3.59–8.91), schizophrenia spec-
trumdisorder (RR 3.82, 95% CI 2.38–5.75), bipolar disorder (RR 5.83,
95% CI 3.11–9.83) and mood disorder (RR 4.10, 95% CI 3.15–5.22).
Risks were high in the first year after diagnosis of TSD and declined
going forward in time.
Conclusions Our findings indicate that acute and posttrau-
matic stress disorder are etiological risk factors for schizophrenia
spectrum disorders and mood disorders. If replicated, this may
underline treatment of traumatized patients in prevention of
severe mental disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.