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Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S93

Background

Cluster B personality disorder (PD) is a highly preva-

lent mental health condition in general population (1 to 6%

depending on the subtype and study). Patients affected are known

to be heavier users of both mental and medical healthcare than

other clinical conditions such as depression. Few studies have

highlighted their elevated mortality rate compared to general pop-

ulation.

Methods

The estimates were produced using data from the inte-

gratedmonitoring system for chronic disease of Quebec. It provides

annual and life prevalence, mortality rate, years of and healthcare

utilization profile Quebec inhabitants.

Results

A total of 7,995,963 people were included in the study.

The life prevalence of cluster B PD is 2.6%. The mean years of lost

life is 13 for men and 9 for women when they are compared to gen-

eral population. The 3 most important causes of death are: suicide

(20.4%), cardiovascular diseases (19.1%) and cancers (18.6%). The

standardized mortality ratio (SMR) for each medical condition is

superior in cluster B personality disorders than general population.

The most important SMR is for suicide (male: 10.2 and female: 21).

In the year 2011–2012, 78% had consulted a general practitioner,

62% a psychiatrist, 41%were admitted in an emergency department

and 21% were hospitalized.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.054

FC51

Correlation between attachment and

personality dimensions and their

association to the

catechol-O-methyltransferase

Val158Met polimorphism

L. Erkoreka

1 ,

, M.I. Macías

2

, A. Arrue

2

, N. Basterreche

2

,

A. Arnaiz

2 , E. G

ordo

2 , O.

Olivas

3 , B. S

antos

4 , M.

I. Zamalloa

2 ,

M. Zumárraga

2 , M.A

. González-Torres

5

1

Mental Health Network of Biscay, Centro Salud Mental Barakaldo,

Barakaldo, Spain

2

Mental Health Network of Biscay, Hospital de Zamudio, Zamudio,

Spain

3

Mental Health Network of Biscay, Centro Salud Mental Gernika,

Gernika, Spain

4

Universidad del País Vasco, Neurociencias, Leioa, Spain

5

Hospital Universitario de Basurto, Servicio de Psiquiatría, Bilbao,

Spain

Corresponding author.

Introduction

Both attachment style and personality traits are

closely related to individual’s interpersonal patterns. Association

between these constructs has been widely studied, but variability

in results makes it difficult to reach definite conclusions. Similarly,

dopaminergic pathways are considered to underlie some person-

ality traits and to be related to attachment styles, but evidence,

hitherto, remain inconclusive.

Aims

To assess the correlation between personality and attach-

ment dimensions and to study whether a common association

to the catechol-O-methyltransferase (COMT) Val158Met polymor-

phism exists.

Methods

One hundred and three Caucasian controls (mean age

39.6

±

6.4; 65% women) were recruited in the province of Bis-

cay, Spain. DAPP-BQ and ECR-Spanish scales were administered to

assess personality and attachment dimensions respectively. DNA

was obtained from saliva and the COMT Val158Met polymorphism

was determined. Pearson’s correlation coefficient and ANOVAwere

calculated using R statistical software.

Results

High positive correlation is observed between inhibi-

tion personality dimension and attachment avoidance (

r

= 0.75).

Besides, both inhibition and avoidance dimensions’ scores are

significantly higher in the COMT ValMet genotype than in the

other genotypes. MetMet: 63.1

±

13.6; ValMet: 71.0

±

13.9; ValVal:

63.0

±

16.7 (ANOVA F = 3.75,

P

= 0.027) for inhibition and Met-

Met: 3.44

±

0.17; ValMet: 3.82

±

0.2; ValVal: 3.33

±

0.23 (ANOVA

F = 3.83,

P

= 0.025) for avoidance.

Conclusions

Attachment patterns are rooted in early interactions

with parental figures, and according to our results they could

be linked to self-perceived personality traits in adulthood. Our

study also suggests that genetics may predispose individuals to

certain interaction styles. Our findings, linking ValMet individuals

to avoidant attachment, are similar to Luijk’s (2011) results, and

would support a genetic-environmental model of both attachment

and personality.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.055

Posttraumatic stress disorder

FC52

Traumatic stress and risk of severe

mental illness: A nationwide cohort

study

N. Okkels

1 , 2 ,

, B. Trabjerg

3

, M. Arendt

2

, C. Bøcker Pedersen

3

1

Department of Affective Disorders, Aarhus University Hospital

Risskov, Risskov, Denmark

2

Clinic for Anxiety Disorders, Aarhus University Hospital Risskov,

Risskov, Denmark

3

National Centre for Register-Based Research, Aarhus University,

Aarhus, Denmark

Corresponding author.

Introduction

A history of traumatic events is prevalent in peo-

ple with schizophrenia spectrum disorders and mood disorders.

However, little is known about their etiological relationship.

Objectives

To explore whether patients with acute or post-

traumatic stress disorder are at higher risk of developing a

schizophrenia spectrum disorder or mood disorder.

Methods

In this prospective cohort study using registers covering

the entire Danish population, we used the Danish Psychiatric Cen-

tral Research Register to identify patients with ICD-10 diagnoses of

acute traumatic stress disorder and/or posttraumatic stress disor-

der. From inpatient and outpatient mental hospitals, we identified

4371 diagnoses withmore than 18 million years of follow-up. Main

outcomes and measures were relative risks (RR) with 95% confi-

dence intervals (95% CI) of schizophrenia, schizophrenia spectrum

disorder, bipolar disorder and mood disorder.

Results

The incidence of traumatic stress disorder (TSD) has

increased steadily from0.6% in 1996 to 6% in 2012, showed a higher

incidence in women and an age distribution with a peak-incidence

in early adulthood. We found that diagnoses of TSD increase the risk

of schizophrenia (RR 5.85, 95% CI 3.59–8.91), schizophrenia spec-

trumdisorder (RR 3.82, 95% CI 2.38–5.75), bipolar disorder (RR 5.83,

95% CI 3.11–9.83) and mood disorder (RR 4.10, 95% CI 3.15–5.22).

Risks were high in the first year after diagnosis of TSD and declined

going forward in time.

Conclusions

Our findings indicate that acute and posttrau-

matic stress disorder are etiological risk factors for schizophrenia

spectrum disorders and mood disorders. If replicated, this may

underline treatment of traumatized patients in prevention of

severe mental disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.056