European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S73
Methods Among the samples, 21,198 analyzed from august 2009
to august 2015 and only those samples containing 25I-NBOMe
were studied (n = 56). Samples were analyzed by Energy Control,
a Spanish harm-reduction NGO that offers users the possibility of
analyzing the substances they intend to consume. Analysis was
done by Gas Chromatography–Mass Spectrometry.
Results From 56 samples were 25I-NBOMe was found, 24 were
bought as LSD (42.8%), 12 as 25I-NBOMe (21.4%), 4 as 25C-NBOMe
(7.1%), 4 as 25I-NBOH (7.1%) and 12 as other substances (21.4%),
gummy bears included. All samples were received from 2012 on,
having the highest peak on 2013 (19 samples).
Conclusions 25I-NBOMe consumption represents an emerging
issue with potential harmful effects, especially when the substance
used is not the expected. Further pharmacokinetic, pharma-
codynamic, clinical and epidemiological researches should be
conducted to deepen knowledge about 25I-NBOMe and the man-
agement of its possible toxic effects. Physicians should be aware of
NPS, their increasing use and the clinical differences between them.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Acknowledgments Supported by grants of ISCIII-FEDER
(RTA-RD12/0028/0009), and The European Commission (Drug Pre-
vention and Information Programme 2014-16,JUST/2013/DPIP/AG/
4823-EU-MADNESS-project). L. Galindo is a Rio Hortega-
fellowship (ISCIII; CM14/00111).
FC03
Alcohol, caffeine and tobacco use
during pregnancy and associated risk
factors in a population-based study
R. Navinés ∗, M.L. Imaz , A. Gutiérrez-Zotes , R. Guillamat ,
C. Francesca , T. Marta , S. Julio , M.S. Rocío
1 Clinic Hospital, Psychiatry, Barcelona, Spain
2 Hospital Universitari Institut Pere Mata, Psychiatry, Reus, Spain
3 Consorci Sanitari, psychiatry, Terrassa, Spain
4 Hospital Universitari de Son Espases, Psychiatry, Palma Mallorca,
Spain
5 Institut de Neuropsiquiatria i Addicions, Psychiatry, Barcelona,
Spain
6 Clinic Hospital, Psychiatry, Valencia, Spain
∗ Corresponding author.
Introduction The use of psychoactive substances is quite
widespread among general population. Data on the prevalence of
drug use among pregnant women are not available for most Euro-
pean countries.
Aims To assess the prevalence of substance use during pregnancy
and associated risk factors with regard to sociodemographic and
obstetric variables, coping strategies, and personality traits.
Methods Design: a population-based, prospective, multicentre
study. Setting: seven teaching hospitals in Spain. Participants: 1804
women were recruited on day 2–3 postpartum. Measurements:
All participants completed a semi-structured interview, including
sociodemographic, reproductive and obstetric variables, personal
and family psychiatric disorders and self-reported drug use during
pregnancy. The STAI, EPQ-R, COPE-28 and the DUKE-UNC question-
naires were administered to assess personality traits, coping skills
and social support.
Results Fifty percent reported substance use during pregnancy.
Of the 909 who did so, 52.5% used caffeine only, 14.7% tobacco
only, 0.8% alcohol only, 24% caffeine and tobacco, 3.6% caffeine
and alcohol, and 2.5% caffeine, tobacco and alcohol, and 1.9% oth-
ers. Lower education (OR = 1.32, 95% CI = 1.00–1.73), sick leave
(OR = 1.74, 95% CI = 1.15–2.63) and personal psychiatry history
(OR = 1.36, 95% CI = 1.04–1.78) were independent factors associated
with substance use during pregnancy. Primiparity was a protective
factor (OR = −0.71, 95%CI = 0.59–0.87), andpsychoticism(OR = 1.02,
95% CI = 1.00–1.03), extraversion (OR = 1.01, 95% CI = 1.00–1.02)
personality traits and the use of substances to cope with emotions
(OR = 2.49, 95% CI = 1.38–4.49) were identified as risk factors.
Conclusions In our non-clinical sample, one out of every two
women reported substance use during pregnancy. Substance use
during pregnancy was associated with sociodemographic char-
acteristics, history of psychiatric disorder, health problems and
specific pattern of personality traits and coping strategies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC04
Maternal smoking during pregnancy
and offpsring’s psychiatric morbidity
in early adulthood. Findings from the
Finnish Family Competence Birth
Cohort Study
S. Niemelä ∗, S. Mikola , A. Sourander , P. Rautava ,
M. Sillanpää
1 University of Oulu, Department of Clinical Neurosciences, Oulu,
Finland
2 University of Turku, Department of Public Health, Turku, Finland
3 University of Turku, Department of Child Psychiatry, Turku, Finland
∗ Corresponding author.
Introduction Prenatal smoking exposure is one of the most com-
mon insults during the fetal period prevalence varying from 5 to
19% in the European countries
Objectives Prenatal smoking exposure increases the risk of psy-
chiatric morbidity in the offspring, externalizing disorders in
particular. However, less is known whether maternal smoking dur-
ing pregnancy increases the risk for anxiety disorders
Aims To study the associations between maternal smoking
during pregnancy and offspring psychiatric morbidity in early
adulthood in a Finnish birth cohort study.
Methods A prospective data collection from 10th gestational
week (GW10) to early adulthood (n = 475, 37% from the original
sample). Information on self-reported smoking during pregnancy
was collected using questionnaires at GW10 and GW28. Off-
spring psychiatric diagnoses and clinically relevant symptoms
were assessed using Development and Well-being Assessment
(DAWBA)-interviews at age 18 to 20 years. Information on parental
alcohol use, depressive mood, anxiety, and education level, as well
as offspring’s gender, education level, and birth weight were used
as covariates.
Results Maternal smoking during pregnancy associated indepen-
dently associated with PTSD (OR = 6.9, 95% CI 1.3–35.6, P = 0.021),
and conduct disorder (OR = 2.7, 95% CI 1.02–6.9, P = 0.046) in a mul-
tivariate analysis after adjusting for other psychiatric diagnoses,
offspring and parental variables (OR = 1.9, 95% CI 0.5–6.9,P = 0.359).
Conclusions In addition to conduct problems, prenatal nicotine
exposure may increase the offspring’s risk for posttraumatic stress
disorder (PTSD). This relationship may be explained, in part, by
effects on nicotinic acetylcholine receptors and uteroplacental
mechanisms
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Reference
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