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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S73

Methods

Among the samples, 21,198 analyzed from august 2009

to august 2015 and only those samples containing 25I-NBOMe

were studied (

n

= 56). Samples were analyzed by Energy Control,

a Spanish harm-reduction NGO that offers users the possibility of

analyzing the substances they intend to consume. Analysis was

done by Gas Chromatography–Mass Spectrometry.

Results

From 56 samples were 25I-NBOMe was found, 24 were

bought as LSD (42.8%), 12 as 25I-NBOMe (21.4%), 4 as 25C-NBOMe

(7.1%), 4 as 25I-NBOH (7.1%) and 12 as other substances (21.4%),

gummy bears included. All samples were received from 2012 on,

having the highest peak on 2013 (19 samples).

Conclusions

25I-NBOMe consumption represents an emerging

issue with potential harmful effects, especially when the substance

used is not the expected. Further pharmacokinetic, pharma-

codynamic, clinical and epidemiological researches should be

conducted to deepen knowledge about 25I-NBOMe and the man-

agement of its possible toxic effects. Physicians should be aware of

NPS, their increasing use and the clinical differences between them.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Acknowledgments

Supported by grants of ISCIII-FEDER

(RTA-RD12/0028/0009), and The European Commission (Drug Pre-

vention and Information Programme 2014-16,JUST/2013/DPIP/AG/

4823-EU-MADNESS-project). L. Galindo is a Rio Hortega-

fellowship (ISCIII; CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.006

FC03

Alcohol, caffeine and tobacco use

during pregnancy and associated risk

factors in a population-based study

R. Navinés

1 ,

, M.L. Imaz

1

, A. Gutiérrez-Zotes

2

, R. Guillamat

3

,

C. Francesca

4

, T. Marta

5

, S. Julio

6

, M.S. Rocío

1

1

Clinic Hospital, Psychiatry, Barcelona, Spain

2

Hospital Universitari Institut Pere Mata, Psychiatry, Reus, Spain

3

Consorci Sanitari, psychiatry, Terrassa, Spain

4

Hospital Universitari de Son Espases, Psychiatry, Palma Mallorca,

Spain

5

Institut de Neuropsiquiatria i Addicions, Psychiatry, Barcelona,

Spain

6

Clinic Hospital, Psychiatry, Valencia, Spain

Corresponding author.

Introduction

The use of psychoactive substances is quite

widespread among general population. Data on the prevalence of

drug use among pregnant women are not available for most Euro-

pean countries.

Aims

To assess the prevalence of substance use during pregnancy

and associated risk factors with regard to sociodemographic and

obstetric variables, coping strategies, and personality traits.

Methods

Design: a population-based, prospective, multicentre

study. Setting: seven teaching hospitals in Spain. Participants: 1804

women were recruited on day 2–3 postpartum. Measurements:

All participants completed a semi-structured interview, including

sociodemographic, reproductive and obstetric variables, personal

and family psychiatric disorders and self-reported drug use during

pregnancy. The STAI, EPQ-R, COPE-28 and the DUKE-UNC question-

naires were administered to assess personality traits, coping skills

and social support.

Results

Fifty percent reported substance use during pregnancy.

Of the 909 who did so, 52.5% used caffeine only, 14.7% tobacco

only, 0.8% alcohol only, 24% caffeine and tobacco, 3.6% caffeine

and alcohol, and 2.5% caffeine, tobacco and alcohol, and 1.9% oth-

ers. Lower education (OR = 1.32, 95% CI = 1.00–1.73), sick leave

(OR = 1.74, 95% CI = 1.15–2.63) and personal psychiatry history

(OR = 1.36, 95% CI = 1.04–1.78) were independent factors associated

with substance use during pregnancy. Primiparity was a protective

factor (OR =

0.71, 95%CI = 0.59–0.87), andpsychoticism(OR = 1.02,

95% CI = 1.00–1.03), extraversion (OR = 1.01, 95% CI = 1.00–1.02)

personality traits and the use of substances to cope with emotions

(OR = 2.49, 95% CI = 1.38–4.49) were identified as risk factors.

Conclusions

In our non-clinical sample, one out of every two

women reported substance use during pregnancy. Substance use

during pregnancy was associated with sociodemographic char-

acteristics, history of psychiatric disorder, health problems and

specific pattern of personality traits and coping strategies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.007

FC04

Maternal smoking during pregnancy

and offpsring’s psychiatric morbidity

in early adulthood. Findings from the

Finnish Family Competence Birth

Cohort Study

S. Niemelä

1 ,

, S. Mikola

2

, A. Sourander

3

, P. Rautava

2

,

M. Sillanpää

2

1

University of Oulu, Department of Clinical Neurosciences, Oulu,

Finland

2

University of Turku, Department of Public Health, Turku, Finland

3

University of Turku, Department of Child Psychiatry, Turku, Finland

Corresponding author.

Introduction

Prenatal smoking exposure is one of the most com-

mon insults during the fetal period prevalence varying from 5 to

19% in the European countries

[1] .

Objectives

Prenatal smoking exposure increases the risk of psy-

chiatric morbidity in the offspring, externalizing disorders in

particular. However, less is known whether maternal smoking dur-

ing pregnancy increases the risk for anxiety disorders

[1] .

Aims

To study the associations between maternal smoking

during pregnancy and offspring psychiatric morbidity in early

adulthood in a Finnish birth cohort study.

Methods

A prospective data collection from 10th gestational

week (GW10) to early adulthood (

n

= 475, 37% from the original

sample). Information on self-reported smoking during pregnancy

was collected using questionnaires at GW10 and GW28. Off-

spring psychiatric diagnoses and clinically relevant symptoms

were assessed using Development and Well-being Assessment

(DAWBA)-interviews at age 18 to 20 years. Information on parental

alcohol use, depressive mood, anxiety, and education level, as well

as offspring’s gender, education level, and birth weight were used

as covariates.

Results

Maternal smoking during pregnancy associated indepen-

dently associated with PTSD (OR = 6.9, 95% CI 1.3–35.6,

P

= 0.021),

and conduct disorder (OR = 2.7, 95% CI 1.02–6.9,

P

= 0.046) in a mul-

tivariate analysis after adjusting for other psychiatric diagnoses,

offspring and parental variables (OR = 1.9, 95% CI 0.5–6.9,

P

= 0.359).

Conclusions

In addition to conduct problems, prenatal nicotine

exposure may increase the offspring’s risk for posttraumatic stress

disorder (PTSD). This relationship may be explained, in part, by

effects on nicotinic acetylcholine receptors and uteroplacental

mechanisms

[1] .

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Reference

[1] Tiesler CM, Heinrich J. Prenatal nicotine exposure and child

behavioural problems. Review. Eur Child Adolesc Psychiatry

2014;23:913–29.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.008