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S70

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S56–S71

Conclusions

Negative symptoms can be observed outside the

schizophrenia diagnosis. However, in order to fully explore the con-

tinuity of negative symptoms, measurement instruments need to

be designed to cover the full range of symptomatology starting at a

subclinical level. We propose the newly developed Zurich Negative

Symptom Scale as a useful tool in this respect.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.979

W46

The second-generation assessment

scales: Brief negative symptom scale

and clinical assessment interview for

negative symptoms

A. Mucci

, S. Galderisi

University of Naples SUN, Department of Psychiatry, Naples, Italy

Corresponding author.

The construct of negative symptoms has undergone significant

changes since the introduction of first generation assessment

scales, such as the Scale for the Assessment of Negative Symptoms

or the Positive and Negative Syndrome Scale. Blunted affect, Alogia,

Asociality, Anhedonia and Avolition are largely recognized as valid

domains of the negative symptoms construct.

Among the new assessment instruments, both the Brief Nega-

tive Symptom Scale (BNSS) and the Clinical Assessment Interview

for Negative Symptoms (CAINS) are considered adequate in their

coverage of the negative symptoms domains. They include the

assessment of both behavior and internal experience for Anhe-

donia, Asociality and Avolition to avoid overlap with functional

outcome measures, as well as consummatory and anticipatory

components of anhedonia with an emphasis on the internal expe-

rience of pleasure.

Strengths and limitations of these newassessment instrumentswill

be reviewed in the light of some existing challenges, such as the dis-

tinction between primary and secondary negative symptoms and

development of innovative treatments.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.980

The impact of societal forces on the mental health

of LGBT populations across cultures

W47

LGBT adolescents in America:

Depression, discrimination and

suicide

A. Ahuja

Los Angeles LGBT Center, Los Angeles, USA

Introduction

The mental health of Adolescents in America is a

major concern for the field of psychiatry. In particular, Lesbian,

Gay, Bisexual and Transgender (LGBT) adolescents are at higher

risk of adverse mental health outcomes. This is largely attributed

to “minority stress” and from outright bullying and discrimination.

In this presentation, this link between bullying and depression will

be explored.

Objectives

By the end of this presentation, the audience will be

able to better understand the link between anti-LGBT bullying and

mental illness and identify the ways to help their patients.

Methods

This presentation is informed by a literature search

from PubMed In addition, it is informed by a symposium previ-

ously done at the American Psychiatric Association (APA) annual

meeting in 2014.

Results

There is clear evidence in the literature that bullying of

LGBT adolescents is pervasive. In addition, LGBT people are more

likely to be depressed than their heterosexual counterparts. This

combination has led to 4-5 times higher rates of attempted sui-

cide by LGBT adolescents. Having Gay-Straight Alliances in schools,

supportive teachers and school administrators, and broader anti-

discrimination legislation has a protective effect on this.

Conclusion

LGBT adolescents are exposed tomore stress by being

a minority in society and by being explicitly bullied and dis-

criminated against. This can lead to depression in some of these

adolescents, and can also lead to suicide in the most vulnerable

among them. There are proven ways to reduce these risks, and

psychiatrists have a role to play in advocating for these reforms.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.981

W48

Cultural variations in LGBT issues

D. Bhugra

World Psychiatric Association, London, United Kingdom

Culturally determined gender roles influence relationships

between different-sex partners, and cultural values affect attitudes

towards sexual variation. LGBT patients face stigma, discrimina-

tion and prejudice and have specific issues related to a number

of factors, in addition to the nature of sexuality. These factors

affect help-seeking and also cause delays in pathways to care. In

specific instances, gay, lesbian and transgender individuals show

higher than expected levels of psychopathology. The clinician’s

attitudes affect therapeutic adherence and therapeutic alliance.

LGBT patients may also have specific issues related to “coming out”

and this may influence their relationships directly and indirectly.

Furthermore, they may experience a reluctance to share their

sexual orientation. Matching of therapists may offer one way

forward but this is not always possible, and may not work due to a

number of reasons.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.982

W49

HIV pre-exposure prophylaxis (PrEP)

and treatment as prevention (TasP):

What mental health providers should

know

T. Hall

University of California-Los Angeles, Center for Behavior and

Addiction Medicine, Los Angeles, USA

Pharmacologic methods of treating and preventing HIV have

advanced tremendously in recent years. Understandings of HIV

risk and recommendations for risk-reduction strategies have also

changed substantially. A majority of new cases of HIV in many

developed countries are now acquired through sex with long-term

partners who are unaware of their HIV-positive status, rather than

from casual or anonymous sexual encounters. Persons with bipolar

disorder and substance use disorders are at particularly high risk.

Mental health providers who work with LGBT persons and other

populations at higher risk for HIV need to understand strategies

their patients are using for HIV risk reduction, and to refer appropri-

ate patients for consideration for pre-exposure prophylaxis (PrEP).

PrEP is the daily use of an antiretroviral (ARV) medication for