European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S56–S71 S67
free, secure video conference application, makes this technology
available literally and virtually everywhere, anywhere, in theworld
at any time.
Results Medical History clearly supports the value of the “house
call” as a means of getting to “see the entire picture”. Chronically ill
patients are frequently visited by home health nurses and or “in
home” medical monitoring programs. Psychiatrically ill patients
may now receive their medication management and behavioral
intervention and assessment right in the privacy of their own
home. Psychiatrists and psychologists merely schedule “in home”
appointmentswith their patients in the samemanner as theywould
if the patient were being seen in their office.
Conclusion Chronically ill patients favored treatment rendered
in “their private space” as well as providers tended to learn much
more about their patients when the provider is the “guest” in the
patients home versus the patient as the “customer” in the providers
office. The convenience and cost savings for both provider and
patient is significant. Availability of spouses, parents etc. was a
valuable addition to the Tele-Home-Behavioral Medicine model.
Disclosure of interest The author has not supplied his declaration
of competing interest.
Social cognition in schizophrenia: Relationship
with neurocognition, functional capacity and
functional outcome
W36
Relationships between
neurocognition, social cognition and
functional outcome in schizophrenia
A. Mucci ∗, S. Galderisi , A. Rossi , P. Rocca , A. Bertolino ,
P. Bucci , M. Maj
1 University of Naples SUN, Department of Psychiatry, Naples, Italy
2 University of L’Aquila, Department of Biotechnological and Applied
Clinical Sciences Section of Psychiatry, L’Aquila, Italy
3 University of Turin, Department of Neuroscience Section of
Psychiatry, Turin, Italy
4 University of Bari, Department of Neurological and Psychiatric
Sciences, Bari, Italy
∗ Corresponding author.
Introduction The inter-relationships of neurocognition, social
cognition, residual psychopathology and real-life functioning are
poorly understood. A largemulticenter studywas carried out by the
Italian Network for Research on Psychoses to model relationships
between neurocognitive deficits, psychopathology and real-life
functioning, taking into account the role of functional capacity and
social cognition.
Methods A structural equation model was used to investigate
direct and indirect effects of neurocognition and psychopathology
on real-life functioning. Social cognition and functional capacity
were modeled as mediators.
Results In 921 patients with schizophrenia, neurocognition had
both direct and indirect effects, through functional capacity and
social cognition, on real-life functioning. Neurocognition predicted
to a large extent social cognition on which depression and disorga-
nization had a modest effect. Social cognition showed a significant
direct impact on real-life functioning.
Conclusion Our results support a strong link between neurocog-
nition and functional outcome, independent of psychopathology.
Social cognition accounted for unique incremental variance in real-
life functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
W37
Social cognition, functional capacity
and symptoms in the longitudinal
prediction of outcome in subjects
with first-episode schizophrenia
M. Nordentoft ∗, R. Wills , D. Gotfredsen
University of Copenhagen, Mental Health Center Copenhagen,
Copenhagen, Denmark
∗ Corresponding author.
Background Several national guidelines recommend continuous
use of antipsychotic medication after a psychotic episode in order
to minimize the risk of relapse. However some studies have identi-
fied a subgroup of patients who can obtain remission of psychotic
symptoms while not being on antipsychotic medication for a long
period of time. This study investigated the long-term outcome and
characteristics of patients in remission of psychotic symptoms with
no use of antipsychotic medication at the 10-year follow-up.
Methods The study was a cohort study including 496 patients
diagnosed with schizophrenia spectrumdisorders (ICD 10: F20 and
F22-29). Patients were included in the Danish OPUS Trial and fol-
lowed up 10 years after inclusion, where patient data was collected
on socio-demographic factors, psychopathology, level of function-
ing and medication.
Findings Among the patients, 30% had remission of psychotic
symptoms at the time of the 10-year follow up with no current
use of antipsychotic medication. This favorable outcome was asso-
ciated with female gender, high GAF-F score, participation in the
labor market and absence of substance abuse.
Interpretation Results from several RCTs advise against discon-
tinuation of antipsychotic medication, but our results from the
10-year follow-up indicate that a subgroup do obtain long-term
remission while not being on antipsychotic medication. Hence,
guidelines on antipsychotic medication do not pay sufficient atten-
tion to patients who discontinue antipsychotic medication and are
still able to obtain remission of psychotic symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
W38
The impact of the different
dimensions of social cognition on
functional outcome in schizophrenia
P. Rocca
Department of Neuroscience, University of Turin, Turin, Italy
Social cognition (SC) refers broadly to the domains of cognitive
functions that are employed in socially relevant situations. These
include three primary domains (i.e., emotion perception, Theory of
Mind-TOM-, and attributional style), as well as more complex and
developing concepts such as social metacognition.
Patients with schizophrenia demonstrate significant deficits across
multiple dimensions of SC and throughout all phases of the illness.
The correlation between SC and real-life functioning ranged from
small to large, mainly depending on the examined aspect of SC, with
largest effects observed for TOM. Indeed, it has been suggested that
TOM difficulties may lead to social misperceptions that influence
how an individual reacts to others, which in turn may lead to mal-
adaptive social patterns and/or social withdrawal, which both may
influence real-life vocational outcome more than neurocognition
(NC) abilities. Moreover, SC appears to act as a mediator between
nonsocial basic NC and community functioning.