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Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S56–S71

S67

free, secure video conference application, makes this technology

available literally and virtually everywhere, anywhere, in theworld

at any time.

Results

Medical History clearly supports the value of the “house

call” as a means of getting to “see the entire picture”. Chronically ill

patients are frequently visited by home health nurses and or “in

home” medical monitoring programs. Psychiatrically ill patients

may now receive their medication management and behavioral

intervention and assessment right in the privacy of their own

home. Psychiatrists and psychologists merely schedule “in home”

appointmentswith their patients in the samemanner as theywould

if the patient were being seen in their office.

Conclusion

Chronically ill patients favored treatment rendered

in “their private space” as well as providers tended to learn much

more about their patients when the provider is the “guest” in the

patients home versus the patient as the “customer” in the providers

office. The convenience and cost savings for both provider and

patient is significant. Availability of spouses, parents etc. was a

valuable addition to the Tele-Home-Behavioral Medicine model.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.969

Social cognition in schizophrenia: Relationship

with neurocognition, functional capacity and

functional outcome

W36

Relationships between

neurocognition, social cognition and

functional outcome in schizophrenia

A. Mucci

1 ,

, S. Galderisi

1

, A. Rossi

2

, P. Rocca

3

, A. Bertolino

4

,

P. Bucci

1

, M. Maj

1

1

University of Naples SUN, Department of Psychiatry, Naples, Italy

2

University of L’Aquila, Department of Biotechnological and Applied

Clinical Sciences Section of Psychiatry, L’Aquila, Italy

3

University of Turin, Department of Neuroscience Section of

Psychiatry, Turin, Italy

4

University of Bari, Department of Neurological and Psychiatric

Sciences, Bari, Italy

Corresponding author.

Introduction

The inter-relationships of neurocognition, social

cognition, residual psychopathology and real-life functioning are

poorly understood. A largemulticenter studywas carried out by the

Italian Network for Research on Psychoses to model relationships

between neurocognitive deficits, psychopathology and real-life

functioning, taking into account the role of functional capacity and

social cognition.

Methods

A structural equation model was used to investigate

direct and indirect effects of neurocognition and psychopathology

on real-life functioning. Social cognition and functional capacity

were modeled as mediators.

Results

In 921 patients with schizophrenia, neurocognition had

both direct and indirect effects, through functional capacity and

social cognition, on real-life functioning. Neurocognition predicted

to a large extent social cognition on which depression and disorga-

nization had a modest effect. Social cognition showed a significant

direct impact on real-life functioning.

Conclusion

Our results support a strong link between neurocog-

nition and functional outcome, independent of psychopathology.

Social cognition accounted for unique incremental variance in real-

life functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.970

W37

Social cognition, functional capacity

and symptoms in the longitudinal

prediction of outcome in subjects

with first-episode schizophrenia

M. Nordentoft

, R. Wills , D. Gotfredsen

University of Copenhagen, Mental Health Center Copenhagen,

Copenhagen, Denmark

Corresponding author.

Background

Several national guidelines recommend continuous

use of antipsychotic medication after a psychotic episode in order

to minimize the risk of relapse. However some studies have identi-

fied a subgroup of patients who can obtain remission of psychotic

symptoms while not being on antipsychotic medication for a long

period of time. This study investigated the long-term outcome and

characteristics of patients in remission of psychotic symptoms with

no use of antipsychotic medication at the 10-year follow-up.

Methods

The study was a cohort study including 496 patients

diagnosed with schizophrenia spectrumdisorders (ICD 10: F20 and

F22-29). Patients were included in the Danish OPUS Trial and fol-

lowed up 10 years after inclusion, where patient data was collected

on socio-demographic factors, psychopathology, level of function-

ing and medication.

Findings

Among the patients, 30% had remission of psychotic

symptoms at the time of the 10-year follow up with no current

use of antipsychotic medication. This favorable outcome was asso-

ciated with female gender, high GAF-F score, participation in the

labor market and absence of substance abuse.

Interpretation

Results from several RCTs advise against discon-

tinuation of antipsychotic medication, but our results from the

10-year follow-up indicate that a subgroup do obtain long-term

remission while not being on antipsychotic medication. Hence,

guidelines on antipsychotic medication do not pay sufficient atten-

tion to patients who discontinue antipsychotic medication and are

still able to obtain remission of psychotic symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.971

W38

The impact of the different

dimensions of social cognition on

functional outcome in schizophrenia

P. Rocca

Department of Neuroscience, University of Turin, Turin, Italy

Social cognition (SC) refers broadly to the domains of cognitive

functions that are employed in socially relevant situations. These

include three primary domains (i.e., emotion perception, Theory of

Mind-TOM-, and attributional style), as well as more complex and

developing concepts such as social metacognition.

Patients with schizophrenia demonstrate significant deficits across

multiple dimensions of SC and throughout all phases of the illness.

The correlation between SC and real-life functioning ranged from

small to large, mainly depending on the examined aspect of SC, with

largest effects observed for TOM. Indeed, it has been suggested that

TOM difficulties may lead to social misperceptions that influence

how an individual reacts to others, which in turn may lead to mal-

adaptive social patterns and/or social withdrawal, which both may

influence real-life vocational outcome more than neurocognition

(NC) abilities. Moreover, SC appears to act as a mediator between

nonsocial basic NC and community functioning.