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S100

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

Method

Two hundred and nineteen stable patients with

schizophrenia (mean age = 31.6 years, 75.3%male gender)were sys-

tematically included in the multicentre network of FondaMental

Expert Center for schizophrenia (FACE-SZ) and assessed with Cal-

gary Depression Scale for depression. High sensitivity CRP (hs-CRP)

was measured with an assay using nephelometry (Dade Behring).

Abnormal CRP level was defined by levels > 3mg/L. Current medi-

cation was recorded.

Results

Overall, 63 subjects (28.8%) were found to have abnor-

mal CRP levels, 43 (20.1%) received a diagnosis of comorbid current

depression, and 51 (31.9%) had ongoing antidepressant treatment.

In univariate analysis, abnormal CRP levels were found to be signif-

icantly associated with metabolic syndrome (

P

= 0.0011) and with

antidepressant consumption (

P

= 0.01), while depression, psychotic

symptomatology, age of onset, illness duration, sociodemographic

characteristics, current tobacco or cannabis status were not (all

P

> 0.05).

In a multivariate model, abnormal CRP was highly associated with

antidepressant consumption independently of other confounding

variables (adjusted odd ratio = 2.9, 95% confidence interval 1.2–6.8).

Conclusion

Abnormal CRP levels in schizophrenia were found

to be associated with antidepressant consumption, but not with

depression.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.072

FC69

Birth by cesarean section and

schizophrenia. Results from the

multi-center FACE-SZ dataset

G. Fond

1 ,

, L. Boyer

2

, P.M. Llorca

3

, M. Leboyer

1

1

Schizophrenia Expert Center Fondation Fondamental, Créteil, France

2

Pôle de psychiatrie universitaire, Pôle de psychiatrie universitaire,

Marseille, France

3

Schizophrenia Expert Center Fondation Fondamental,

Clermont-Ferrand, France

Corresponding author.

Objectives

Children born by cesarean section (“c-birth”) are

known to have different microbiota and a natural history of differ-

ent disorders including allergy, asthma and overweight compared

to vaginally born (“v-birth”) children. C-birth is not known to

increase the risk of schizophrenia (SZ), but to be associated with

an earlier age at onset. To further explore possible links between

c-birth and SZ, we compared clinical and biological characteristics

of c-born SZ patients compared to v-born ones.

Method

Four hundred and fifty-four stable community-dwelling

SZ patients (mean age = 32.4 years, 75.8% male gender) were sys-

tematically included in the multicentre network of FondaMental

Expert Center for schizophrenia (FACE-SZ).

Results

Overall, 49 patients (10.8%) were c-born. These patients

had a mean age at schizophrenia onset of 21.9

±

6.7 years, a

mean duration of illness of 10.5

±

8.7 years and a mean PANSS

total score of 70.9

±

18.7. None of these variables was signifi-

cantly associated with c-birth. Multivariate analysis showed that

c-birth remained associated with lower peripheral inflammation

(aOR = 0.07; 95% CI 0.009–0.555,

P

= 0.012) and lower premorbid

ability (aOR = 0.945; 95% CI 0.898–0.994,

P

= 0.03) independently of

age, age at illness onset, sex, education level, psychotic and mood

symptomatology, antipsychotic treatment, tobacco consumption,

birth weight and mothers suffering from schizophrenia or bipolar

disorder.

Conclusion

Altogether, literature data as well as our results sug-

gest that c-birth is associated with lower weight gain and lower

inflammation in schizophrenia, which could be explained bymicro-

biota differences. Further studies should take into account c-birth

when exploring the role of microbiota in SZ patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.073

FC70

Abnormal connectivity in dorsolateral

prefrontal cortex in schizophrenia

patients and unaffected relatives

L. Galindo

1 ,

, F. P

astoriza

2 , D.

Bergé

3 , A. M

ané

3 , N.

Roé

3 ,

N. Pujol

3

, M. Picado

3

, A. Bulbena

3

, V. Perez

4

, O. Vilarroya

5

1

IMIM Foundation, Neuropsychiatry and Addictions Institute INAD of

Parc de Salut Mar, Barcelona, Spain

2

IMIM Foundation, Psychiatry, Barcelona, Spain

3

Neuropsychiatry and Addictions Institute of Parc de Salut Mar,

IMIM Foundation, Barcelona, Spain

4

Neuropsychiatry and Addictions Institute of Parc de Salut Mar,

IMIM Foundation. Universitat Autònoma de Barcelona, CIBERSAM

G21, Barcelona, Spain

5

Universitat Autònoma de Barcelona, IMIM Foundation, Barcelona,

Spain

Corresponding author.

Objectives

The aim of this study is to explore connectivity of

the left dorsolateral prefrontal cortex (LDLPC) by functional mag-

netic resonance imaging during resting state, in subjects affected

by schizophrenia and unaffected relatives.

Methods

We recruited a group of 29 patients diagnosed with

schizophrenia, who were treated with atypical antipsychotics, who

are andwere clinically stable in the last 6months and had an illness

duration range from 5 up to 15 years. We also recruited a group of

23 unaffected relatives, without history of other mental, neurolog-

ical or somatic disease and a group of 37 healthy volunteers. No

subject in any of the three groups met criteria for substance use

disorders.

All three groups were clinically evaluated, and a functional mag-

netic resonance during Resting State was performed.

Functional images were reoriented to the first scan, normalized to

theMNI EPI template and smoothedwith an 8mmGaussian kernel,

with SPM. The CONN-FMRI Toolbox v1.2was used to create individ-

ual subject seed-to-voxel connectivity maps, to the corresponding

seeds of the default mode network.

Results

Fig. 1 .

Conclusions

Our results show a significant increase in connec-

tivity between LDLPC and anterior prefrontal cortex, dorsolateral

prefrontal cortex and somatosensory association areas, especially

between patients and controls. It is noteworthy to mention that

we found a significant decrease in connectivity between LDLPC and

supramarginal gyrus, superior temporal gyrus and somatosensory

association areas between unaffected relatives and controls.