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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S103

Methods

Forty-four schizophrenia cases and 35 with other

psychoses from the Northern Finland Birth Cohort 1966 were

scanned on a 1.5T GE Signa scanner and brain structures

were extracted using volBrain automated volumetry system

( http://volbrain.upv.es

). Data of antipsychotic medication were

collected from medical records and interviews. We used linear

regression model to analyze the effect of antipsychotic medication

on brain volumes and used intracranial volume and onset age as

covariates.We

alsoperformed additional analyses adding psychotic

symptoms (PANSS Total score) as a covariate.

Results

Higher lifetime and current dose associated to left lateral

ventricle increase (

b

= 0.33,

P

= 0.033;

b

= 0.307,

P

= 0.042, respec-

tively) and right and left accumbens decrease (

b

=

0.405,

P

= 0.013,

b

=

0.404,

P

= 0.010;

b

=

0.302,

P

= 0.027,

b

=

0.282,

P

= 0.036,

respectively) in schizophrenia but not in other psychoses. When

PANSS was added to the model, the findings remained regarding

right and left accumbens, but not regarding left lateral ventricle.

Conclusions

It seems that antipsychotic medication affects the

brain in schizophrenia, but not in the heterogeneous group of

other psychoses. In schizophrenia, brain changes associated to

antipsychotic medication cannot be explained by illness duration

or symptom severity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.077

FC74

Association between drug-induced

hyperprolactinemia related adverse

events on women schizophrenia

patients with DRD2 Taq1

polymorphism

J.J. Moon

1

, J.M. An

1

, J.C. Shim

1

, D.U. Jung

1 ,

, B.G. Kong

1

,

J.W. Kang

1 , D.W

. Jeon

1 , H.S

. Kim

2

1

Inje University Busan Paik Hospital, Psychiatry, Busan, Republic of

Korea

2

Inje University Busan Paik Hospital, Clinical Pharmacology, Busan,

Republic of Korea

Corresponding author.

Objectives

To observe the association between adverse effects

of long-term use of antipsychotic drugs in female schizophrenic

patients anddopamineD2 receptor (DRD2), cytochrome P450 (CYP)

2D6,

estrogen receptor-

˛

gene (ESR1).

Method

The subjects were 89 female schizophrenic patients (age

range from 18 to 40) who had been taking the same medication for

more than 3 months. The adverse effects with regard to hyperpro-

lactinemia were studied through the blood collection at one point

of the subjects. Furthermore, the effect of DRD2, CYP2D6, ESR1 on

serum prolactin level and amenorrhea was analyzed.

Results

There was a lower concentration of E2 in patients

with amenorrhea. In addition, an inverse correlation was found

between prolactin level and E2 level. Hyperprolactinemia (HPRL)

was commonly found in patients who had been using risperidone,

amisulpride and paliperidone; in contrast, HPRL was found less

in those who had been taking aripiprazole, olanzapine, ziprasi-

done, clozapine and quetiapine. Moreover, female schizophrenic

patients who had DRD2 Taq1 A1 allele had twice the chance of

developing amenorrhea than those who did not have A1 allele.

Female schizophrenic patients who had Taq1 A1 allele also had

48% higher concentration level of prolactin than those who did not

have A1 allele. There was no association found between prolactin

and CYP2D6 or ESR1.

Conclusion

Female schizophrenic patients who had DRD2 Taq1

A1 allele showed high prolactin level and high-frequency of HPRL.

Therefore, reducing the use of prolactin-elevating antipsychotics

for female schizophrenic patients with DRD2 Taq1 A1 allele would

be one method minimizing the adverse effects of drug-induced

hyperprolactinemia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.078

FC75

Affectivity during social behaviour in

a schizophrenic-like rat

L. Kai

1 ,

, D .

Gill

2 , G.

Wegener

3 , A.

Tasker

2

1

Aarhus University, Translation Neuropsychiatry Unit, Aarhus,

Denmark

2

University of Prince Edward Island, Biomedical Department,

Charlottetown, Canada

3

Aarhus University, Translational Neuropsychiatry Unit, Aarhus,

Denmark

Corresponding author.

Introduction

Rats are social animals that produce high-frequency

whistles said to reflect their underlying affective state. Injecting

rats with a glutamate agonist (domoic acid) at a sensitive period of

brain development, models aspects of schizophrenia. This is known

as the neonatal DOM model.

Aims

We investigated whether DOM rats display altered social

behaviour – as seen in patients with schizophrenia – using their

high-frequency whistles as a proxy for the emotional valence of

social situations.

Methods

We used 19 male Sprague Dawley rats, injected with

either a low-dose of domoic acid or saline at postnatal days 8 to 14.

The social behaviour of the rats was investigated at four levels:

– anticipation of social interaction;

– dyadic encounter;

– three-chamber test;

– tickling.

Tests were carried out at postnatal days 34 to 40 and 50 to 56. Rat

whistles were recorded on all days of testing.

Results

In progress.

Conclusions

The interest in rat whistles as a supplement to tra-

ditional behavioural tests has increased. New software allows for

detailed qualitative analysis of the whistle subtypes and thus new

complexity to their interpretation. This study can help unravel

information encoded in the whistles and shed light on the social

behaviour of the DOM rat thus investigating it is applicability as a

model of schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.079

FC76

Maternal obstetric complications and

intellectual functioning in patients

with schizophrenia and their healthy

siblings

H. Karakula-Juchnowicz

1 ,

, D. Juchnowicz

2

, P. Krukow

3

,

J. Morylowska-Topolska

3 , J. P

awezka

4 , M.

Flis

5 , R. M

arkiewicz

6 ,

A. Urbanska

4

1

Medical University of Lublin, Department of Clinical

Neuropsychiatry I Department of Psychiatry Psychotherapy and Early

Intervention, Lublin, Poland

2

University of Pedagogy of Bialystok, Department of Psychology,

Białystok, Poland

3

Medical University of Lublin, Department of Clinical

Neuropsychiatry, Lublin, Poland

4

Medical University of Lublin, II Department of Psychiatry and

Psychiatric Rehabilitation, Lublin, Poland

5

Medical University of Lublin, I Department of Psychiatry

Psychotherapy and Early Intervention, Lublin, Poland