European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S103
Methods Forty-four schizophrenia cases and 35 with other
psychoses from the Northern Finland Birth Cohort 1966 were
scanned on a 1.5T GE Signa scanner and brain structures
were extracted using volBrain automated volumetry system
). Data of antipsychotic medication were
collected from medical records and interviews. We used linear
regression model to analyze the effect of antipsychotic medication
on brain volumes and used intracranial volume and onset age as
alsoperformed additional analyses adding psychotic
symptoms (PANSS Total score) as a covariate.
Results Higher lifetime and current dose associated to left lateral
ventricle increase (b = 0.33, P = 0.033; b= 0.307, P= 0.042, respec-
tively) and right and left accumbens decrease (b= −0.405, P = 0.013,
b = −0.404, P = 0.010; b = −0.302, P = 0.027, b = −0.282, P = 0.036,
respectively) in schizophrenia but not in other psychoses. When
PANSS was added to the model, the findings remained regarding
right and left accumbens, but not regarding left lateral ventricle.
Conclusions It seems that antipsychotic medication affects the
brain in schizophrenia, but not in the heterogeneous group of
other psychoses. In schizophrenia, brain changes associated to
antipsychotic medication cannot be explained by illness duration
or symptom severity.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC74
Association between drug-induced
hyperprolactinemia related adverse
events on women schizophrenia
patients with DRD2 Taq1
polymorphism
J.J. Moon , J.M. An , J.C. Shim , D.U. Jung ∗, B.G. Kong ,
J.W. Kang . Jeon . Kim
1 Inje University Busan Paik Hospital, Psychiatry, Busan, Republic of
Korea
2 Inje University Busan Paik Hospital, Clinical Pharmacology, Busan,
Republic of Korea
∗ Corresponding author.
Objectives To observe the association between adverse effects
of long-term use of antipsychotic drugs in female schizophrenic
patients anddopamineD2 receptor (DRD2), cytochrome P450 (CYP)
2D6, estrogen receptor-˛ gene (ESR1).
Method The subjects were 89 female schizophrenic patients (age
range from 18 to 40) who had been taking the same medication for
more than 3 months. The adverse effects with regard to hyperpro-
lactinemia were studied through the blood collection at one point
of the subjects. Furthermore, the effect of DRD2, CYP2D6, ESR1 on
serum prolactin level and amenorrhea was analyzed.
Results There was a lower concentration of E2 in patients
with amenorrhea. In addition, an inverse correlation was found
between prolactin level and E2 level. Hyperprolactinemia (HPRL)
was commonly found in patients who had been using risperidone,
amisulpride and paliperidone; in contrast, HPRL was found less
in those who had been taking aripiprazole, olanzapine, ziprasi-
done, clozapine and quetiapine. Moreover, female schizophrenic
patients who had DRD2 Taq1 A1 allele had twice the chance of
developing amenorrhea than those who did not have A1 allele.
Female schizophrenic patients who had Taq1 A1 allele also had
48% higher concentration level of prolactin than those who did not
have A1 allele. There was no association found between prolactin
and CYP2D6 or ESR1.
Conclusion Female schizophrenic patients who had DRD2 Taq1
A1 allele showed high prolactin level and high-frequency of HPRL.
Therefore, reducing the use of prolactin-elevating antipsychotics
for female schizophrenic patients with DRD2 Taq1 A1 allele would
be one method minimizing the adverse effects of drug-induced
hyperprolactinemia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC75
Affectivity during social behaviour in
a schizophrenic-like rat
L. Kai ∗ Gill Wegener Tasker
1 Aarhus University, Translation Neuropsychiatry Unit, Aarhus,
Denmark
2 University of Prince Edward Island, Biomedical Department,
Charlottetown, Canada
3 Aarhus University, Translational Neuropsychiatry Unit, Aarhus,
Denmark
∗ Corresponding author.
Introduction Rats are social animals that produce high-frequency
whistles said to reflect their underlying affective state. Injecting
rats with a glutamate agonist (domoic acid) at a sensitive period of
brain development, models aspects of schizophrenia. This is known
as the neonatal DOM model.
Aims We investigated whether DOM rats display altered social
behaviour – as seen in patients with schizophrenia – using their
high-frequency whistles as a proxy for the emotional valence of
social situations.
Methods We used 19 male Sprague Dawley rats, injected with
either a low-dose of domoic acid or saline at postnatal days 8 to 14.
The social behaviour of the rats was investigated at four levels:
– anticipation of social interaction;
– dyadic encounter;
– three-chamber test;
– tickling.
Tests were carried out at postnatal days 34 to 40 and 50 to 56. Rat
whistles were recorded on all days of testing.
Results In progress.
Conclusions The interest in rat whistles as a supplement to tra-
ditional behavioural tests has increased. New software allows for
detailed qualitative analysis of the whistle subtypes and thus new
complexity to their interpretation. This study can help unravel
information encoded in the whistles and shed light on the social
behaviour of the DOM rat thus investigating it is applicability as a
model of schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC76
Maternal obstetric complications and
intellectual functioning in patients
with schizophrenia and their healthy
siblings
H. Karakula-Juchnowicz ∗, D. Juchnowicz , P. Krukow ,
J. Morylowska-Topolska awezka Flis arkiewicz
A. Urbanska
1 Medical University of Lublin, Department of Clinical
Neuropsychiatry I Department of Psychiatry Psychotherapy and Early
Intervention, Lublin, Poland
2 University of Pedagogy of Bialystok, Department of Psychology,
Białystok, Poland
3 Medical University of Lublin, Department of Clinical
Neuropsychiatry, Lublin, Poland
4 Medical University of Lublin, II Department of Psychiatry and
Psychiatric Rehabilitation, Lublin, Poland
5 Medical University of Lublin, I Department of Psychiatry
Psychotherapy and Early Intervention, Lublin, Poland