European Psychiatry - Volume 33 - March 2016

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S102 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115
strategies (especially positive self-instruction) explains 52.8% of
the overall score variance of self-stigma
Conclusions This study revealed that there is a connection
between self-stigma and coping strategies in patients suffering
from schizophrenia spectrum disorders.
Table 1 Description of the sample, demographic and clinic at data.
Table 2 Description of using coping strategies and self-stigma in
outpatients.
Table 3 Correlations between self-stigma and coping strategies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC73
Lifetime antipsychotic use and brain
structures in schizophrenia and other
psychoses – 43-year study of the
Northern Finland Birth Cohort 1966
S. Huhtaniska ∗, I. Korkala , T. Heikka , J. Tohka ,
J. Manjon , P. Coupe , J. Remes , J. Moilanen , V. Kiviniemi ,
L. Björnholm , M. Isohanni , J. Veijola , G. Murray ,
E. Jääskeläinen , J. Miettunen
1 University of Oulu, Institute of Clinical Medicine, Research Unit for
Clinical Neurosciences, Oulu, Finland
2 University of Oulu, Center for Life Course Epidemiology and Systems
Medicine, Oulu, Finland
3 Oulu University Hospital and University of Oulu, Medical Research
Center Oulu, Oulu, Finland
4 Universidad Carlos III de Madrid, Department of Bioengineering and
Aerospace Engineering, Madrid, Spain
5 Universitat Politècnica de València, Instituto de Aplicaciones de las
Tecnologías de la Información y de las Comunicaciones Avanzadas,
Valencia, Spain
6 Laboratoire Bordelais de Recherche en Informatique, Unité Mixte de
Recherche CNRS UMR 5800, PICTURA Research Group, 351, cours de
la Libération, Talence, France
7 Oulu University Hospital, Department of Diagnostic Radiology,
Oulu, Finland
8 Oulu University Hospital, Department of Psychiatry, Oulu, Finland
9 University of Cambridge, Department of Psychiatry, Cambridge,
United Kingdom
10 University of Cambridge, Behavioural and Clinical Neuroscience
Institute, Cambridge, United Kingdom
∗ Corresponding author.
Introduction The effects of long-term antipsychotic medication
use on structural brain changes in psychoses are still unknown.
Severity and duration of illness are key confounders when evalu-
ating antipsychotic effects on brain morphology.
Objectives Understanding the role of antipsychotic medication
on brain morphology in psychoses.
Aims To analyze whether cumulative lifetime or current
antipsychotic medication dose relates to brain morphology in
schizophrenia and other psychoses at age of 43 years.