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S102

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

strategies (especially positive self-instruction) explains 52.8% of

the overall score variance of self-stigma

( Tables 1–3 ).

Conclusions

This study revealed that there is a connection

between self-stigma and coping strategies in patients suffering

from schizophrenia spectrum disorders.

Table 1

Description of the sample, demographic and clinic at data.

Table 2

Description of using coping strategies and self-stigma in

outpatients.

Table 3

Correlations between self-stigma and coping strategies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.076

FC73

Lifetime antipsychotic use and brain

structures in schizophrenia and other

psychoses – 43-year study of the

Northern Finland Birth Cohort 1966

S. Huhtaniska

1 , 2 , 3 ,

, I. Korkala

1 , 2

, T. Heikka

1

, J. Tohka

4

,

J. Manjon

5

, P. Coupe

6

, J. Remes

7

, J. Moilanen

3 , 8

, V. Kiviniemi

7

,

L. Björnholm

1

, M. Isohanni

1 , 8

, J. Veijola

1 , 3 , 8

, G. Murray

9 , 10

,

E. Jääskeläinen

1 , 2 , 3 , 8

, J. Miettunen

1 , 2 , 3 , 8

1

University of Oulu, Institute of Clinical Medicine, Research Unit for

Clinical Neurosciences, Oulu, Finland

2

University of Oulu, Center for Life Course Epidemiology and Systems

Medicine, Oulu, Finland

3

Oulu University Hospital and University of Oulu, Medical Research

Center Oulu, Oulu, Finland

4

Universidad Carlos III de Madrid, Department of Bioengineering and

Aerospace Engineering, Madrid, Spain

5

Universitat Politècnica de València, Instituto de Aplicaciones de las

Tecnologías de la Información y de las Comunicaciones Avanzadas,

Valencia, Spain

6

Laboratoire Bordelais de Recherche en Informatique, Unité Mixte de

Recherche CNRS UMR 5800, PICTURA Research Group, 351, cours de

la Libération, Talence, France

7

Oulu University Hospital, Department of Diagnostic Radiology,

Oulu, Finland

8

Oulu University Hospital, Department of Psychiatry, Oulu, Finland

9

University of Cambridge, Department of Psychiatry, Cambridge,

United Kingdom

10

University of Cambridge, Behavioural and Clinical Neuroscience

Institute, Cambridge, United Kingdom

Corresponding author.

Introduction

The effects of long-term antipsychotic medication

use on structural brain changes in psychoses are still unknown.

Severity and duration of illness are key confounders when evalu-

ating antipsychotic effects on brain morphology.

Objectives

Understanding the role of antipsychotic medication

on brain morphology in psychoses.

Aims

To analyze whether cumulative lifetime or current

antipsychotic medication dose relates to brain morphology in

schizophrenia and other psychoses at age of 43 years.