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S104

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

6

Medical University of Lublin, Department of Psychiatric Nursing

Faculty of Nursing and Health Sciences, Lublin, Poland

Corresponding author.

Objectives

Intellectual functioning in schizophrenia has been

associated with genetic vulnerability and obstetric complications.

Aims

The aim of this study was to assess:

– the incidence of complications during pregnancy, labor and deliv-

ery;

– the association of OCs with general intellectual ability in two

groups: patients with schizophrenia and their healthy siblings.

Methods

Forty-two patients with schizophrenia according to

DSM-IV and 43 their healthy siblings were included in the study

and examined using MINI and WAIS-R. Their mothers were inter-

viewed to gather data on OCs. The ‘midwife protocol’ of Parnas et al.

was used to quantify the presence and entity of OCs.

Results

Asphyxia, mother’s serious illness during pregnancy, pre-

mature delivery with weight < 2500 g, labor time > 48 h, infarcts in

the placenta and eclampsia were statistically more frequent in

schizophrenic group. OCs were more common in individuals with

a family history. The two investigated groups were different in

the following WAIS-R subtests: comprehension (

P

= 0.018), block

design (

P

= 0.0001), digit symbol (

P

= 0.001), as well as in perfor-

mance IQ and total IQ. In the patient group, correlations between

OCs indexes and WAIS-R results include all intelligence quotients

(verbal, performance, total IQ) and 5 WAIS-R subtests, while in the

sibling group: verbal and total IQ and 2 subtests. The correlation

between Vocabulary subtest and OCs was the strongest in both

groups.

Conclusion

OCs may interact with genetic vulnerability to

increase the risk of schizophrenia and have been associated with

cognitive deficits in the patient group.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.080

FC77

Premorbid social adjustment is better

in cannabis-using than non-using

psychotic patients across Europe

L. Ferraro

1 ,

, V. Capuccio

2

, A. Mulè

1

, C. La Cascia

1

, L. Sideli

1

,

G. Tripoli

1

, F. Seminerio

1

, C. Sartorio

1

, D. La Barbera

1

,

R. Murray

3

, M. Di Forti

4

1

University of Palermo, Psychiatry, Palermo, Italy

2

University of Palermo, Statistics, Palermo, Italy

3

King’s College of London, Psychosis Studies, London, United Kingdom

4

King’s College of London, Social, Genetic and Developmental

Psychiatry, London, United Kingdom

Corresponding author.

Introduction

A number of authors have hypothesized that psy-

chotic patients who consume cannabis constitute a differentiated

subgroup of patients that have better cognitive and social skills,

necessary to engage in illegal drug consumption, than non-using

patients.

Objectives

Given that the prevalence, and patterns, of cannabis

use are culturally driven, we wanted to study first-episode psy-

chosis (FEP) cannabis-using and non-using patients coming from

different European countries as part of the EUGEI-STUDY.

Aims

We tested the hypothesis of better premorbid social adjust-

ment in cannabis-using FEP patients, by comparing themto FEP non

cannabis users and to their respective healthy controls.

Methods

A total of 1745 people (746 cases; 999 controls) com-

pleted the assessment for premorbid adjustment [Premorbid

Adjustment Scale (PAS)] and cannabis use (CEQ-Revised). We first

extracted the Premorbid Social Adjustment Factor (PSA) from PAS

and then performedlinear mixed models with PSA as depend-

ent variable and cannabis lifetime (Yes/No) and subject status

(Cases/Controls) as independent variables. We then considered

“Country” as random intercept.

Results

Across all countries, PSA scores were better in patients

who had smoked cannabis in their lifetime than patients who

had not (

P

= 0.009). The difference in PSA score between cannabis

users and non-users was significantly greater in cases than con-

trols (

P

= 0.038). The relationship between PSA, cannabis lifetime

(Yes/No) and subject status among nations (random intercept) is

shown on

Fig. 1 .

Conclusions

Cannabis-using psychotic patients show better pre-

morbid social adjustment than non-using patients, across 5

European countries.

Fig. 1

PSA scores by subject status (cases/controls) and cannabis

use (yes/no) across different countries.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.081

FC78

Disrupted thalamo-orbitofrontal but

not fronto-temporal white matter

connectivity in people with

schizotypal personality disorder

T.Y. Lee

, S.N. Kim , J.S. Kwon

Seoul National University College of Medicine, Psychiatry, Seoul,

Republic of Korea

Corresponding author.

Introduction

Despite patients with schizophrenia showed the

deficits in the fronto-temporal and thalamo-frontal connectivity,

the white matter connectivity in patients with schizotypal person-

ality disorder had not been systemically investigated.

Methods

This study involved 40 neuroleptic-naïve patients

with schizotypal personality disorder (SPD), 60 patients with

schizophrenia (SCZ), and 100 healthy controls (HC), and scanned on

the 3TMRI scanner. Probablistic tractography was performed using

the FATCAT software in AFNI. The target brain regions (bilateral lat-

eral frontal, medial frontal, orbitofrontal, temporal and thalamus)

were extracted from the automated segmentation and corti-

cal parcellation. Cross-sectional comparisons in mean fractional

anisotropy (FA) performed on the thalamo-lateral frontal, thalamo-

medial frontal, thalamo-orbitofrontal, lateral frontal-temporal and