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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S105

orbitofrontal-temporal pathway. We also analyzed the relationship

between the white matter pathway and the Positive and Negative

Syndrome Scale and GAF.

Results

The diffusion tensor imaging showed that SCZ and SPD

had decreased FA in the left thalamo-orbitofrontal pathway. How-

ever, SPD showed no alteration in the fronto-temporal pathway,

despite SCZ showed decreased FA in the left temporo-orbitofrontal

pathway. In SCZ, there were significant correlations between FA

value in the left temporo-orbitofrontal pathway and negative

symptoms score in PANSS and GAF score. However, SPD showed

the trend level relationship between the GAF score and FA value in

the left temporo-orbitofrontal pathway.

Conclusion

These results suggest that the deficits in thalamo-

frontal connectivity may be a trait marker of schizophrenia

spectrumdisorder, and the deficits in fronto-temporal connectivity

may play a key role towards the vulnerability of psychosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.082

FC79

Trends of hospitalization for

schizoaffective disorder (SD) in USA: A

nationwide analysis

Z. Mansuri

1 ,

, S. Shambhu

1

, P. Yadav

2

, M. Rathod

1

, U. Mansuri

3

1

Drexel University, School of Public Health, Philadelphia, USA

2

Thomas Jefferson University, Kimmel Cancer Center, Philadelphia,

USA

3

Icahn School of Medicine at Mount Sinai, School of Public Health,

New York, USA

Corresponding author.

Objectives

Schizoaffective disorder (SD) is an important cause of

morbidity andmortality in hospitalized patients.While SDhas been

extensively studied in the past, the contemporary data for impact

of SD on cost of hospitalization are largely lacking.

Methods

We queried the Healthcare Cost and Utilization

Project’s Nationwide Inpatient Sample (HCUP-NIS) dataset

between 1998–2011 using the ICD-9 codes. Severity of comorbid

conditions was defined by Deyo modification of Charlson comor-

bidity index. Primary outcome was in-hospital mortality and

secondary outcome was total charges for hospitalization. Using

SAS 9.2, Chi

2

test,

t

-test and Cochran-Armitage test were used to

test significance.

Results

A total of 4,66,800 patients were analyzed; 50.90% were

female and 49.10% male (

P

< 0.0001); 61.15% were white, 25.97%

black and 12.88% of other race (

P

< 0.0001). Rate of hospitaliza-

tion increased from 13,035.05/million to 26,703.21/million from

1998–2011. Overall mortality was 0.50% and mean cost of hos-

pitalization was 20,995.19$. The in-hospital mortality increased

from 0.46% to 0.50% (

P

< 0.0001) and mean cost of hospitaliza-

tion increased from 11,504.94$ to 31,460.67$. Total spending on

SD related admissions increased from $1.2 billion/year to $6.6 bil-

lion/year.

Conclusions

While mortality has slightly increased from 1998 to

2011, the cost has significantly increased from $1.2 billion/year to

$6.6 billion/year which leads to an estimated $5.4 billion/year addi-

tional burden to US health care system. In the era of cost conscious

care, preventing SD related hospitalization could save billions of

dollars every year. Focused efforts are needed to establish preven-

tive measures for SD related hospitalization.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.083

FC80

Trends of hospitalization for

schizophrenia in USA: A nationwide

analysis

Z. Mansuri

1 ,

, M. Rathod

1

, A. Sutaria

1

, S. Shambhu

1

, P. Yadav

2

,

U. Mansuri

3

1

Drexel University, School of Public Health, Philadelphia, USA

2

Thomas Jefferson University, Kimmel Cancer Center, Philadelphia,

USA

3

Icahn School of Medicine at Mount Sinai, School of Public Health,

New York, USA

Corresponding author.

Objectives

Schizophrenia is an important cause of morbidity and

mortality in hospitalized patients. While schizophrenia has been

extensively studied in the past, the contemporary data for impact

of schizophrenia on cost of hospitalization are largely lacking.

Methods

We queried the Healthcare Cost and Utilization

Project’s Nationwide Inpatient Sample (HCUP-NIS) dataset

between 1998–2011 using the ICD-9 codes. Severity of comorbid

conditions was defined by Deyo modification of Charlson comor-

bidity index. Primary outcome was in-hospital mortality and

secondary outcome was total charges for hospitalization. Using

SAS 9.2, Chi

2

test,

t

-test and Cochran-Armitage test were used to

test significance.

Results

A total of 443,659 patients were analyzed; 38.78% were

female and 61.22% were male (

P

< 0.0001); 48.19% were white,

35.30% black and 16.51% of other race (

P

< 0.0001). Rate of hos-

pitalization increased from 56,768.47/million to 79,44466/million

from1998–2011. Overall mortalitywas 0.70% andmean cost of hos-

pitalization was 23,568.47$. The in-hospital mortality decreased

from 0.75% to 0.73% (

P

< 0.0001) and mean cost of hospitaliza-

tion increased from 12,775.64$ to 36,768.58$. Total spending on

schizophrenia related admissions have increased from $1.75 bil-

lion/year $6.23 billion/year.

Conclusions

While mortality has slightly decreased from 1998 to

2011, the cost has significantly increased from $1.75 billion/year

to $6.23 billion/year which leads to an estimated $4.48 billion/year

additional burden to US health care system. In the era of cost con-

scious care, preventing schizophrenia related hospitalization could

save billions of dollars every year. Focused efforts are needed to

establish preventive measures for schizophrenia related hospital-

ization.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.084

FC81

Electrophysiological mechanisms

underlying ERP amplitude reduction

in patients with schizophrenia: A

time-frequency analysis

D.D. Marasco

1 ,

, A. Vignapiano

2

, G. Di Lorenzo

3

, A. Mucci

2

,

M. Altamura

1

, A. Petito

1

, M. Caroprese

1

, C. Niolu

3

, A. Bellomo

1

,

S. Galderisi

2

1

Laboratory of Neurophysiology, Department of Clinical and

Experimental Medicine, Section of Psychiatry, University of Foggia,

Foggia, Italy

2

Department of Psychiatry, University of Naples SUN, Naples, Italy

3

Department of Systems Medicine, University of Rome “Tor Vergata”,

Rome, Italy

Corresponding author.

Background

It is hypothesized that the event-related poten-

tials are generated by different electrophysiological mechanisms,

i.e., event-related power increase and enhanced degree of phase-

locking over trial. The study aimed to characterize the relative