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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

S109

Conclusions

Interview-based assessment of cognition with the

CAI allows for the prediction of everyday functioning in patients

with psychosis. Impairment in almost all CAI cognitive domains,

except for social cognition, was associated with poorer psychoso-

cial functioning.

Fig. 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.093

FC90

Cerebral hemodynamics in

schizophrenia during the Trail Making

Test: A functional transcranial

Doppler sonography study

D. Schuepbach

1 , S. E

gger

2 ,

, S .C

. Herpertz

3

1

Zentrum für Psychiatrie Weinsberg, Clinic of General Psychiatry and

Psychotherapy, Sector West, Weinsberg, Germany

2

Psychiatric University Hospital Zurich, Department of Psychiatry,

Psychotherapy and Psychosomatics, Zurich, Switzerland

3

University of Heidelberg, Department of General Psychiatry,

Heidelberg, Germany

Corresponding author.

Introduction

Schizophrenia is a severe mental disorder, with

complex symptoms involving psychosis, negative symptoms and

cognitive impairment. The Trail Making Test (TMT) has beenwidely

used to assess attention and executive function. Functional trans-

cranial Doppler sonography (fTCD) of basal cerebral arteries allows

monitoring of aberrant cerebral hemodynamics during cognitive

tasks in this patient group.

Objectives

We assessed cerebral hemodynamics in the middle

cerebral arteries (MCA) using fTCDwhile patients with schizophre-

nia and healthy subjects performed the TMT and a control task.

Methods

Fifteen patients with chronic schizophrenia and 15

healthy controls performed the TMT-A and -B during fTCD mea-

surements of the MCA. Dependent measures were performance,

mean cerebral blood flow velocity (MFV) and the lateralization.

Results

Patients demonstrated an overall decreased speed of

solution (

P

= 0.002), and there was no significant effect of age.

They showed a significantly increased flow pattern for the TMT-B

(

P

= 0.005). There were no lateralization differences between diag-

nostic groups.

Conclusions

There was a performance deficit in patients with

schizophrenia for both TMT-A and -B that fits well with results of

existing literature. The aberrant hemodynamic response supports

the idea that cognitive performance elicits an aberrant cerebral

hemodynamic correlate. It adds to the notion that fTCD is a valuable

tool to correlate psychological paradigms with brain perfusion in

patients with schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.094

FC91

Does family history of schizophrenia

affect the severity of disease?

M. Sisek- ˇSprem

, M.

Herceg , V. Juki´c

University Psychiatric Hospital Vrapˇce, Integral Ward, Zagreb,

Croatia

Corresponding author.

Introduction

Previous studies have demonstrated that family his-

tory is associated with earlier age at onset, severity of positive and

negative symptoms, and the duration of untreated illness. Hered-

itary factors may contribute a vulnerability for antisocial and/or

violent behaviour per se, and for other stable characteristics such

as aggressive behaviour.

Aim

To analyze the impact of family history of schizophrenia

and aggressive behavior among members of family on severity of

disease and aggressive behavior of patients.

Method

The study population consisted of 120 male

schizophrenic patients classified into non-aggressive (

n

= 60)

and aggressive (

n

= 60) groups, based on indication for admission

in hospital (aggression/anything else but aggression). For severity

of disease, we assessed psychopathology using the Positive and

Negative Syndrome Scale (PANSS), the number of hospitalizations

and the total equivalent dose of therapy (collected from medical

record). The presence of a family history and aggression in family

was assessed using a semi-structured interview of patients and,

when available, family members.

Results

Twenty-seven (22.5%) participants were determined to

have at least one family member with schizophrenia or another

psychotic disorder, with no difference between aggressive (10%)

and non-aggressive (12.5%) group. Therewas no significant interac-

tion between family history and severity of disease (PANSS, number

of hospitalizations, total equivalent dose of therapy). Aggressive

behaviour in first-degree family member had no influence on

aggressive behaviour of patients with schizophrenia.

Conclusion

Family history of schizophrenia does not affect the

severity of disease nor aggressive behaviour.

Keywords

Family history; Schizophrenia; Severity of disease;

Aggressive behavior

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.095

FC92

Soluble Fas ligand (sFasL) as a

predictor of reduction of general

psychopathology in schizophrenia

after antipsychotic treatment

K. Szymona

1 ,

, H .

Karakula-Juchnowicz

2 , B. Z

dzisinska

3 ,

M. Flis

4 , K.

Kaławaj

3 , W.

Rosa

5 , M.

Kandefer-Szersze ´n

3

1

Medical University of Lublin, Mental Health Outpatient Clinic,

Lublin, Poland

2

Medical University of Lublin, Department of Psychiatry,

Psychotherapy and Early Intervention, Lublin, Poland

3

Maria Curie-Skłodowska University in Lublin, Department of

Virology and Immunology, Lublin, Poland

4

Medical University of Lublin, Department of Clinical

Neuropsychiatry, Lublin, Poland

5

Lublin University of Technology, Department of Applied

Mathematics, Lublin, Poland

Corresponding author.