European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115 S109
Conclusions Interview-based assessment of cognition with the
CAI allows for the prediction of everyday functioning in patients
with psychosis. Impairment in almost all CAI cognitive domains,
except for social cognition, was associated with poorer psychoso-
cial functioning.
Fig. 1
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC90
Cerebral hemodynamics in
schizophrenia during the Trail Making
Test: A functional transcranial
Doppler sonography study
D. Schuepbach gger ∗ . Herpertz
1 Zentrum für Psychiatrie Weinsberg, Clinic of General Psychiatry and
Psychotherapy, Sector West, Weinsberg, Germany
2 Psychiatric University Hospital Zurich, Department of Psychiatry,
Psychotherapy and Psychosomatics, Zurich, Switzerland
3 University of Heidelberg, Department of General Psychiatry,
Heidelberg, Germany
∗ Corresponding author.
Introduction Schizophrenia is a severe mental disorder, with
complex symptoms involving psychosis, negative symptoms and
cognitive impairment. The Trail Making Test (TMT) has beenwidely
used to assess attention and executive function. Functional trans-
cranial Doppler sonography (fTCD) of basal cerebral arteries allows
monitoring of aberrant cerebral hemodynamics during cognitive
tasks in this patient group.
Objectives We assessed cerebral hemodynamics in the middle
cerebral arteries (MCA) using fTCDwhile patients with schizophre-
nia and healthy subjects performed the TMT and a control task.
Methods Fifteen patients with chronic schizophrenia and 15
healthy controls performed the TMT-A and -B during fTCD mea-
surements of the MCA. Dependent measures were performance,
mean cerebral blood flow velocity (MFV) and the lateralization.
Results Patients demonstrated an overall decreased speed of
solution (P = 0.002), and there was no significant effect of age.
They showed a significantly increased flow pattern for the TMT-B
(P = 0.005). There were no lateralization differences between diag-
nostic groups.
Conclusions There was a performance deficit in patients with
schizophrenia for both TMT-A and -B that fits well with results of
existing literature. The aberrant hemodynamic response supports
the idea that cognitive performance elicits an aberrant cerebral
hemodynamic correlate. It adds to the notion that fTCD is a valuable
tool to correlate psychological paradigms with brain perfusion in
patients with schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
FC91
Does family history of schizophrenia
affect the severity of disease?
M. Sisek- ˇSprem∗ Herceg , V. Juki´c
University Psychiatric Hospital Vrapˇce, Integral Ward, Zagreb,
Croatia
∗ Corresponding author.
Introduction Previous studies have demonstrated that family his-
tory is associated with earlier age at onset, severity of positive and
negative symptoms, and the duration of untreated illness. Hered-
itary factors may contribute a vulnerability for antisocial and/or
violent behaviour per se, and for other stable characteristics such
as aggressive behaviour.
Aim To analyze the impact of family history of schizophrenia
and aggressive behavior among members of family on severity of
disease and aggressive behavior of patients.
Method The study population consisted of 120 male
schizophrenic patients classified into non-aggressive (n = 60)
and aggressive (n = 60) groups, based on indication for admission
in hospital (aggression/anything else but aggression). For severity
of disease, we assessed psychopathology using the Positive and
Negative Syndrome Scale (PANSS), the number of hospitalizations
and the total equivalent dose of therapy (collected from medical
record). The presence of a family history and aggression in family
was assessed using a semi-structured interview of patients and,
when available, family members.
Results Twenty-seven (22.5%) participants were determined to
have at least one family member with schizophrenia or another
psychotic disorder, with no difference between aggressive (10%)
and non-aggressive (12.5%) group. Therewas no significant interac-
tion between family history and severity of disease (PANSS, number
of hospitalizations, total equivalent dose of therapy). Aggressive
behaviour in first-degree family member had no influence on
aggressive behaviour of patients with schizophrenia.
Conclusion Family history of schizophrenia does not affect the
severity of disease nor aggressive behaviour.
Keywords Family history; Schizophrenia; Severity of disease;
Aggressive behavior
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
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Soluble Fas ligand (sFasL) as a
predictor of reduction of general
psychopathology in schizophrenia
after antipsychotic treatment
K. Szymona ∗ Karakula-Juchnowicz dzisinska
M. Flis Kaławaj Rosa Kandefer-Szersze ´n
1 Medical University of Lublin, Mental Health Outpatient Clinic,
Lublin, Poland
2 Medical University of Lublin, Department of Psychiatry,
Psychotherapy and Early Intervention, Lublin, Poland
3 Maria Curie-Skłodowska University in Lublin, Department of
Virology and Immunology, Lublin, Poland
4 Medical University of Lublin, Department of Clinical
Neuropsychiatry, Lublin, Poland
5 Lublin University of Technology, Department of Applied
Mathematics, Lublin, Poland
∗ Corresponding author.