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S106

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S115

contribution of these mechanisms to the ERP in patients with

schizophrenia (SCZ).

Materials and methods

One hundred and fifteen chronic stabi-

lized SCZ and 62 healthy controls (HC) recruited to the study of the

Italian Network for Research on Psychoses were included. Scalp

potentials were recorded during a standard auditory oddball task.

Stimulus-locked segments were extracted for all standard trials

and correctly hit target trials. Trials contaminated by other artifacts

were rejected. For each subject and stimulus type the event-related

spectral perturbation (ERSP) and the inter-trial-coherence (ITC)

were computed to assess event-related power increase and inter-

trial phase-locking. The two groups were compared using Student’s

t

-test followed by Bonferroni correction for multiple comparisons.

Results

SCZ presented a reduced amplitude of bothN100 and P3b.

For both standard and target stimuli, at Cz and Pz, ERSPwas reduced

in SCZ in the delta-theta band (from 0 up to 400ms). The ITC index,

at the same channels, was reduced in SCZ in the delta band for

standard stimuli (from 0 to 300ms), and in both delta and theta

bands for target stimuli (from 300 to 400ms).

Conclusions

Our results indicate that alterations of both mecha-

nisms are involved in N100 and P3b amplitude reduction observed

in SCZ. Inter-trial phase-locking abnormalities for N100 were

limited to the delta band, while for P3b involved delta and theta

frequencies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.085

FC82

Methylenetetrahydrofolate reductase

(

MTHFR

) gene polymorphisms and

antipsychotic-induced metabolic

disturbances in first-episode

schizophrenia patients

B. Misiak

1 ,

, Ł. Łaczma ´nski

2

, K. Słoka

2

, E. Szmida

3

, R. ´Sl˛ezak

3

,

P. Piotrowski

1

, A. Kiejna

1

, D. Frydecka

1

1

Wroclaw Medical University, Department of Psychiatry, Wroclaw,

Poland

2

Wroclaw Medical University, Department of Endocrinology and

Diabetology, Wroclaw, Poland

3

Wroclaw Medical University, Department of Genetics, Wroclaw,

Poland

Corresponding author.

Introduction

There is a scarcity of prospective studies addressing

the influence of the

methylenetetrahydrofolate reductase

(

MTHFR

)

gene polymorphisms on antipsychotic-induced metabolic changes

in first-episode schizophrenia (FES) patients.

Objectives

We aimed at investigating metabolic side effects

of second-generation antipsychotics (SGAs) with respect to the

MTHFR

gene polymorphisms in FES patients.

Methods

Polymorphisms in the

MTHFR

gene (C677T and A1298C)

were investigatedwith respect to changes in bodymass index (BMI)

and waist circumference (WC) together with serum levels of glu-

cose, lipids, homocysteine, vitamin B12 and folate after 12 weeks

of treatment with SGAs in 135 FES patients.

Results

The 677TT genotype was associated with significantly

higher BMI, WC and serum levels of triglycerides, as well as signif-

icantly lower folate levels at baseline. Additionally, the 677T allele

was associatedwith significantly lower folate levels at baseline. The

677CC homozygotes had significantly higher increase in BMI and

serum levels of triglycerides. The 677TT genotype predicted sig-

nificantly higher increase in homocysteine levels and significantly

higher decrease in folate levels. These associations were also signif-

icant in the allelic analysis. Only the patients with the 677T allele

had significantly lower folate levels and significantly higher homo-

cysteine levels at the follow-up. The 677T allele was also related to

significantly lower increase in WC. The 1298CC homozygotes had

significantly higher weight gain in the course of treatment with

SGAs.

Conclusions

The

MTHFR

gene polymorphisms might predict

antipsychotic-induced weight gain in FES patients. In addition, the

MTHFR

C677T polymorphismmight be also predictive with respect

to other metabolic adversities of SGAs.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.086

FC83

Clinical symptomatology and theory

of mind in schizophrenia: Which

relationship?

J. Mrizak

, R. Trabelsi , A. Arous , A. Aissa , H. Ben Ammar ,

Z. El Hechmi

Razi Hospital, Psychiatry F, Mannouba, Tunisia

Corresponding author.

Introduction

Theory of mind (ToM) has repeatedly been shown to

be compromised inmany patients with schizophrenia (SCZ). It now

seems to be quitewell-established that patientswithprofoundneg-

ative or disorganized symptoms perform poorly on ToM tasks. By

contrast, findings in patients with predominant positive symptoms

are much more ambiguous.

Objectives

To investigate the relationship between ToM deficits

and different symptoms dimensions in SCZ.

Methods

Fifty-eight outpatients with stable SCZ completed the

intention-inferencing task (IIT), in which the ability to infer a char-

acter’s intentions from 28 short comic strip stories is assessed.

Symptomatology evaluation comprised the Positive and Nega-

tive Syndrome Scale (PANSS), the Calgary Depression Scale for

Schizophrenia (CDSS) and the Clinical Global Impressions Scale

Improvement and severity (CGI).

Results

The number of correct answers in the IIT negatively cor-

related with both the positive (

P

= 0.015) and negative (

P

< 0.0001)

scales of the PANSS. ToM deficits were correlated with the

conceptual disorganization, hallucinations and the suspicious-

ness/persecution items.

The patients who had more false answers in the IIT also had signifi-

cantly higher scores at the positive (

P

= 0.005), negative (

P

< 0.0001)

and general (

P

< 0.0001) scales of the PANSS. Worse IIT performance

correlated with a higher severity index in the CGI. No correlations

were found between IIT scores and CDSS scores.

Conclusions

Our results confirm the relationship between ToM

deficits and negative symtomps and suggest that ToM may also be

correlated to specific positive symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.087

FC84

Effectiveness of long-acting

injectables and clozapine in a

real-world setting during the

early-stages of psychotic illness

E.G. Ostinelli

, E. G

uanella , S. Cavallotti , C. Casetta ,

A. D’Agostino

San Paolo Hospital, Department of Health Sciences, Milan, Italy

Corresponding author.

Introduction

Intervention in the early-stages of psychosis may

be able to shape the clinical course; critical period (CP) is best

represented by the first 5 years from first admission (FA).

Objectives

To investigate the effectiveness of pharmacological

intervention within and beyond the CP.