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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S237

longitudinal prospective observational study in which subjects will

be submitted to various psychiatric assessments by conducting a

radiological examination that is the MRI and MRS to determine the

regional metabolic pattern in the subjects explored.

Methods

Informed consent to all patients, aged more than

18 years, selected according inclusion/exclusion criteria that meet

ethical principles. Patients are selected within the public health

network of Sacyl Health Care System, Zamora Hospital, Spain.

Expected results and conclusions

Schizophrenia increased cre-

atinine, choline and glutamate. NAA decrease in untreated

patients and increased the same in patients with treatment

Alzheimer: < increased NAA (N-acetyl aspartate) and increased MI

(myo-inositol), their relationship has a high negative predictive

value, ie if it is negative (the peaks are not increased) is discarded

Alzheimer’s disease. Early Dx/screening? Treatment?

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.471

EW354

Gender differences in neural

activation during perceptual

uncertainty in patients with major

depression

T. Sobanski

1 ,

, H. Sauer

2

, K.J. Bär

2

, G. Wagner

2

1

Thueringen-Kliniken GmbH, Psychiatry, Psychotherapy and

Psychosomatic Medicine, Saalfeld, Germany

2

Friedrich Schiller University, Psychiatry and Psychotherapy, Jena,

Germany

Corresponding author.

Introduction

Although male and female patients with major

depression (MDD) differ in psychopathology and other illness char-

acteristics, a potentially confounding effect of gender has not been

systematically controlled or investigated in most of the previous

neuroimaging studies.

Objectives

We investigated activation patterns during processing

of ambiguous stimuli in MDD by functional MRI.

Aims

We aimed at examining potential activation differences

between male and female patients.

Methods

A matching task was employed in which two stimuli

with varying degrees of perceptual uncertainty had to be compared

with respect to their sameness. Eighteen patients meeting DSM-IV

criteria of MDD and eighteen healthy control subjects participated

in this study.

Results

Whereas on the level of behavioral performance no sig-

nificant group differences could be detected we found distinct

disorder- and gender-related differences in the brain activation.

Patients activated significantly stronger in superior parietal, pre-

frontal and cingulate regions. Gender specific analyses revealed

that the hyperactivity in the patient group was mainly attributable

to hyperactivity in the male patients who activated significantly

stronger than the female patients in an extensive fronto-temporo-

limbic network, which partly overlapped with the network we

found when comparing patients and healthy controls.

Discussion

Our results indicate that male patients seem to be

reliant on a significantly stronger metabolism in task-relevant

regions to maintain an equal level of performance.

Conclusion

The present results provide evidence for gender-

related differences in the functional organization of the brain in

patients with MDD. Gender differences should be taken into con-

sideration when investigating the neural correlates of MDD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.472

EW355

Searching for meaning in meaningless

gestures, pathologic activity in

amygdala, hippocampus and temporal

pole during planning of gestures in

schizophrenia

K. Stegmayer

1 ,

, B. Stephan

2 , 3

, V. Tim

2 , 3

, F. Andrea

1

,

W. Roland

4

, M. Rene

5

, S. Werner

1

, W. Sebastian

1

1

Psychiatric University Hostpital Bern, Department of Psychiatry,

Bern, Switzerland

2

Neurology and Neurorehabilitation Center, Kantonsspital Luzern,

Luzern, Switzerland

3

Department of Clinical Research, University Hospital, Inselspital,

Bern, Switzerland

4

Institute of Neuroradiology, Inselspital, Bern, Switzerland

5

Department of Neurology, University Hospital, Inselspital, Bern,

Switzerland

Corresponding author.

Introduction

Schizophrenia is characterized by poor social inter-

action contributing to poor functional outcome. Particularly

nonverbal communication is disturbed. Neural correlates of

impaired gesturing are currently unclear. We thus tested func-

tional correlates of gesturing in schizophrenia patients and healthy

controls.

Methods

We tested 22 patients and 25 controls with an event-

related fMRI (instructed delay) paradigm to dissociate brain

activation during planning and execution of meaningful (e.g. use

scissors) and meaningless novel gestures. Preprocessing included

realignment, coregistration, normalization and spatial smoothing.

We used a two stage mixed effects model for statistical analysis.

Conditions were contrasted against a linguistic control within and

between groups. We correlated psychopathological characteristics

with beta estimates of brain areas with between group effects.

Results

During planning and execution of both gesture subtypes

both groups activated brain areas of the ventral and dorsal stream.

However patients’ activity was less prominent and more left lat-

eralized. During planning patients showed additional activity in

bilateral temporal poles, amygdala and hippocampus associated

with the level of delusions. Furthermore patients had increased

dorsomedial prefrontal cortex and precuneus activity when plan-

ning meaningless gestures.

Conclusion

During the planning of meaningless gestures we

detected aberrant activation of limbic structures in patients typ-

ically implicated in delusion formation, which also correlated with

current severity of delusions. Moreover, planning of meaningless

gestures relied on areas relevant for strategic control and atten-

tion. These results argue for a pathologic search for meaning in

neutral gestures and increased control effort during planning of

meaningless gestures in schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.473

Obsessive-compulsive disorder

EW356

Behavioral phenotypes in patients

with obsessive-compulsive disorder

comorbid with schizophrenia

L. Dehelean

1 ,

, A.M. Draghici

2

, R.S. Romosan

1

, I. Papava

1

1

“Victor Babes” University of Medicine and Pharmacy,

Neuroscience/Psychiatry, Timisoara, Romania