European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S237
longitudinal prospective observational study in which subjects will
be submitted to various psychiatric assessments by conducting a
radiological examination that is the MRI and MRS to determine the
regional metabolic pattern in the subjects explored.
Methods Informed consent to all patients, aged more than
18 years, selected according inclusion/exclusion criteria that meet
ethical principles. Patients are selected within the public health
network of Sacyl Health Care System, Zamora Hospital, Spain.
Expected results and conclusions Schizophrenia increased cre-
atinine, choline and glutamate. NAA decrease in untreated
patients and increased the same in patients with treatment
Alzheimer: < increased NAA (N-acetyl aspartate) and increased MI
(myo-inositol), their relationship has a high negative predictive
value, ie if it is negative (the peaks are not increased) is discarded
Alzheimer’s disease. Early Dx/screening? Treatment?
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW354
Gender differences in neural
activation during perceptual
uncertainty in patients with major
depression
T. Sobanski ∗, H. Sauer , K.J. Bär , G. Wagner
1 Thueringen-Kliniken GmbH, Psychiatry, Psychotherapy and
Psychosomatic Medicine, Saalfeld, Germany
2 Friedrich Schiller University, Psychiatry and Psychotherapy, Jena,
Germany
∗ Corresponding author.
Introduction Although male and female patients with major
depression (MDD) differ in psychopathology and other illness char-
acteristics, a potentially confounding effect of gender has not been
systematically controlled or investigated in most of the previous
neuroimaging studies.
Objectives We investigated activation patterns during processing
of ambiguous stimuli in MDD by functional MRI.
Aims We aimed at examining potential activation differences
between male and female patients.
Methods A matching task was employed in which two stimuli
with varying degrees of perceptual uncertainty had to be compared
with respect to their sameness. Eighteen patients meeting DSM-IV
criteria of MDD and eighteen healthy control subjects participated
in this study.
Results Whereas on the level of behavioral performance no sig-
nificant group differences could be detected we found distinct
disorder- and gender-related differences in the brain activation.
Patients activated significantly stronger in superior parietal, pre-
frontal and cingulate regions. Gender specific analyses revealed
that the hyperactivity in the patient group was mainly attributable
to hyperactivity in the male patients who activated significantly
stronger than the female patients in an extensive fronto-temporo-
limbic network, which partly overlapped with the network we
found when comparing patients and healthy controls.
Discussion Our results indicate that male patients seem to be
reliant on a significantly stronger metabolism in task-relevant
regions to maintain an equal level of performance.
Conclusion The present results provide evidence for gender-
related differences in the functional organization of the brain in
patients with MDD. Gender differences should be taken into con-
sideration when investigating the neural correlates of MDD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW355
Searching for meaning in meaningless
gestures, pathologic activity in
amygdala, hippocampus and temporal
pole during planning of gestures in
schizophrenia
K. Stegmayer ∗, B. Stephan , V. Tim , F. Andrea ,
W. Roland , M. Rene , S. Werner , W. Sebastian
1 Psychiatric University Hostpital Bern, Department of Psychiatry,
Bern, Switzerland
2 Neurology and Neurorehabilitation Center, Kantonsspital Luzern,
Luzern, Switzerland
3 Department of Clinical Research, University Hospital, Inselspital,
Bern, Switzerland
4 Institute of Neuroradiology, Inselspital, Bern, Switzerland
5 Department of Neurology, University Hospital, Inselspital, Bern,
Switzerland
∗ Corresponding author.
Introduction Schizophrenia is characterized by poor social inter-
action contributing to poor functional outcome. Particularly
nonverbal communication is disturbed. Neural correlates of
impaired gesturing are currently unclear. We thus tested func-
tional correlates of gesturing in schizophrenia patients and healthy
controls.
Methods We tested 22 patients and 25 controls with an event-
related fMRI (instructed delay) paradigm to dissociate brain
activation during planning and execution of meaningful (e.g. use
scissors) and meaningless novel gestures. Preprocessing included
realignment, coregistration, normalization and spatial smoothing.
We used a two stage mixed effects model for statistical analysis.
Conditions were contrasted against a linguistic control within and
between groups. We correlated psychopathological characteristics
with beta estimates of brain areas with between group effects.
Results During planning and execution of both gesture subtypes
both groups activated brain areas of the ventral and dorsal stream.
However patients’ activity was less prominent and more left lat-
eralized. During planning patients showed additional activity in
bilateral temporal poles, amygdala and hippocampus associated
with the level of delusions. Furthermore patients had increased
dorsomedial prefrontal cortex and precuneus activity when plan-
ning meaningless gestures.
Conclusion During the planning of meaningless gestures we
detected aberrant activation of limbic structures in patients typ-
ically implicated in delusion formation, which also correlated with
current severity of delusions. Moreover, planning of meaningless
gestures relied on areas relevant for strategic control and atten-
tion. These results argue for a pathologic search for meaning in
neutral gestures and increased control effort during planning of
meaningless gestures in schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Obsessive-compulsive disorder
EW356
Behavioral phenotypes in patients
with obsessive-compulsive disorder
comorbid with schizophrenia
L. Dehelean ∗, A.M. Draghici , R.S. Romosan , I. Papava
1 “Victor Babes” University of Medicine and Pharmacy,
Neuroscience/Psychiatry, Timisoara, Romania