European Psychiatry - Volume 33 - March 2016

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S240 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Methods We consecutively recruited 57 first-visit DSM-V OCD
patients (females = 66.7%; age range = 18–63 years) at the Psychi-
atric Outpatient Clinic of our University Hospital. These patients
were affected by severe OCD, as shown by a median (1st
quartile–3rd quartile) Yale-Brown Obsessive-Compulsive Scale
(Y-BOCS) score of 27.0 (23.0–32.5). We used the point-biserial
coefficient (rpbi ) to measure the correlation between psychopatho-
logical dimensions, as assessed with the Scale for the Rapid
Assessment of Psychopathology (SVARAD), and obsession sub-
types, as evaluated with the Y-BOCS.
Results We found significant correlations (P-values < 0.05)
between: anger/aggressiveness dimension and aggressive, con-
tamination, and sexual obsessions; apprehension/fear dimension
and contamination, religious, and somatic obsessions; sad-
ness/demoralization dimension and contamination and somatic
obsessions; obsessiveness/iterativity dimension and all obses-
sion subtypes; impulsivity dimension and aggressive and sexual
obsessions; somatic concern/somatization dimension and con-
tamination and somatic obsessions. We also found, by using
the Mann-Whitney U-test, that OCD patients with comorbid
Obsessive-Compulsive Personality Disorder–but not Schizotypal
or Histrionic ones–showed higher levels (P < 0.05) of obsessive-
ness/iterativity and anger/aggressiveness than OCD patients
without the personality disorder.
Conclusions Anger and other psychopathological dimensions
seem to be linked with specific obsession subtypes in OCD patients,
suggesting an association between these dimensions and OCD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW363
Does cognitive flexibility moderate
the relationship between disgust
sensitivity and contamination fear?
E. Powell
Ferndown, United Kingdom
High disgust sensitivity and poor cognitive flexibility have been
independently identified as contributing factors in the aetiology
of obsessive-compulsive disorder. This study looks at the rela-
tionship between contamination fear and disgust sensitivity in a
non-clinical population. In particular, at whether two moderat-
ing factors, cognitive flexibility and emotional reappraisal, have
a buffering influence. One hundred participants from an under-
graduate population completed a battery of questionnaires which
rated their disgust and level of contamination fear. They also com-
pleted a set-shifting task to assess cognitive flexibility and an
emotion regulation questionnaire. The mean age of the sample
was 21.4 years with 62% of the sample population being female.
SPSS 16 was used to correlate the main variables using Pear-
son’s correlation andmoderated regression, usingMODPROBE, was
used for analysis. Results confirmed previous findings that high
disgust sensitivity is significantly associated with contamination
fear (P < 0.01). In addition to this, both cognitive flexibility and
emotional reappraisal reduced the influence that disgust has on
an individual’s contamination fear. Cognitive flexibility and emo-
tion reappraisal were not found to be significantly correlated to
each other (P = 0.511), which suggest that these variables moderate
the relationship between disgust and contamination fear indepen-
dently of each other. Individuals with poor cognitive flexibility
and/or poor emotional reappraisal were found to have high lev-
els of contamination fear, which suggests that these two variables
may attenuate the relationship between disgust and contamina-
tion fear. Future implications of these findings have been discussed
although further research is needed to confirm these conclusions
in a clinical population.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW364
The comorbidity of cluster C
personality disorders in obsessive
compulsive disorder as a marker of
anxiety and depression severity
A. Pozza ∗, S. Domenichetti , G.P. Mazzoni , D. Dèttore
1 University of Florence, Department of Experimental and Clinica
Medicine, Florence, Italy
2 Florence Healthcare Services, Department of Mental Health,
Florence, Italy
3 “Studi Cognitivi” Cognitive Psychotherapy and Research Center,
Postgraduate Program on Cognitive Psychotherapy, Florence, Italy
4 University of Florence, Department of Health Sciences, Florence,
Italy
∗ Corresponding author.
Introduction Comorbid Cluster C Personality Disorders (PDs) are
the most prevalent PDs in Obsessive-Compulsive Disorder (OCD).
Investigating clinical correlates associated to OCD with Cluster C
PDs may allow identifying tailored treatment strategies.
Objectives The current study examined whether OCD with
comorbid cluster C PDs is associated to more severe OCD symp-
toms, anxiety and depression relative to OCDwith comorbid cluster
B PDs or OCD alone.
Methods Two hundred thirty-nine patients with OCD were
included (mean age = 35.64, SD = 11.08, 51% females). Seventeen
percent had a comorbid Cluster C PD, 8% had a comorbid Cluster
B PD, and 75% had OCD alone. The Structured Clinical Interview
for Axis II Disorders, Yale-Brown Obsessive Compulsive Scale, Beck
Anxiety Inventory, Beck Depression Inventory-II were adminis-
tered.
Results Patients with comorbid Cluster C PDs reported more
severe depression and anxiety than those with comorbid Cluster
B PDs ( F = 10.48, P < 0.001) or with OCD alone (F = 9.10, P < 0.001).
Patients with comorbid Cluster C PDs had more severe OCD symp-
toms than those with OCD alone but not than those with comorbid
Cluster B PDs (F = 3.12, P < 0.05).
Conclusions OCDwith Cluster C PDs could be a subtypewithmore
severe anxiety and depression. These findings could be explained
with the fact that Cluster C PDs are characterized by behaviours,
which can be seen as maladaptive attempts to cope with anxiety
and depression. Tailored treatment strategies for OCD with comor-
bid Cluster C PDs are discussed to target co-occurring anxiety and
depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW365
Group cognitive behavioural therapy
for outpatients with
obsessive-compulsive disorder in a
psychiatric service in Italy
A. Pozza ∗, S. Domenichetti , A. Tanini , E. Ruggieri ,
D. Dèttore
1 University of Florence, Department of Experimental and Clinical
Medicine, Florence, Italy
2 Healthcare Services of Florence, Department of Mental Health,
Florence, Italy
3 University of Florence, Department of Health Sciences, Florence,
Italy
∗ Corresponding author.