European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S239
suppression as a principle of exposure and response prevention
(ERP) has a stronger effect on reactive obsessions.
Aims To compare the effectiveness of two coping strategies
(acceptance and response suppression) on autogenous and reactive
obsessions.
Methods A total of 164 undergraduate students completed
questionnaires for obsessional thoughts and coping strategies.
According to the most distressing thought, sixty subjects (n = 30
with autogenous obsession, n = 30 with reactive obsession) were
randomly assigned to two groups differing in treatment conditions.
Individual psychoeducation and practice were performed for four
different groups (2 obsessional subtypes × 2 coping strategies).
Results Repeated measure ANOVA demonstrated that the autog-
enous obsessional group showed greater distress reduction
after acceptance treatment than response suppression treatment,
although its effect was not statistically significant. However, the
reactive obsessional group did not show the interaction effect
between distress reduction and the two coping strategies.
Conclusions The results suggest that coping strategies have dif-
ferential effects on distress reduction of obsessional subtypes.
Different therapeutic approaches may need to be offered to indi-
viduals with autogenous and reactive obsessions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW360
Adjuvant treatment of resistant
obsessive-compulsive disorder with
memantine: A case report
D. Mota ∗, A. Oliveira , J. Silva , M. Fernandes , J. Ribeiro ,
V. Martins , F. Duarte , M. Marques , A.T. Pereira ,
J. Andrade , A.F. Macedo
1 Centro Hospitalar e Universitario de Coimbra, CRI de Psiquiatria e
Saúde Mental, Coimbra, Portugal
2 Faculty of Medicine, University of Coimbra, Department of Medical
Psychology, Coimbra, Portugal
∗ Corresponding author.
Introduction OCD could be a very disabling condition, imply-
ing severe impairment of social and occupational functioning
and decreased quality of life. OCD is treated with a combination
of psychopharmacological treatments and cognitive-behavioural
therapy. Clomipramine was the first anti-obsessive drug, and was
followed by selective serotonin re-uptake inhibitors (SSRIs), both
modulating serotoninergic transmission. Low dose atypical anti-
psychotic are sometimes used to potentiate serotoninergic agents.
Growing evidence based on animal models and on neuroimaging
shows that glutamatergic transmission could play an important
role in the aetiology of OCD. Therefore, glutamate modulators such
as N-methyl-D-aspartate (NMDA) receptor antagonists became the
focus of the search of novel treatments for OCD. One of this drugs,
memantine, already approved for Alzheimer disease treatment,
was used off-label the first time ten years ago in resistant case
of OCD with positive results. Besides some further successful case
reports, there are a single-blind case control study and a cou-
ple of randomized, double-blind, placebo-controlled trials showing
improvement of OCD symptoms with memantine adjuvant phar-
macotherapy.
Objectives and aims To describe a case report of off-label treat-
ment of a severe resistant case of OCD with memantine, after
15weeks of treatment.
Methods Literature review and case description. Before begin-
ning treatment with memantine, the patient made a psychological
assessement (baseline) with a battery of tests (MINI Plus, Y-BOCS,
QPP-15, WDQ, ECPAD, OP2, OAS2, MPS-H&F, MPS-F, HEXACO-PI-
R, MOCI, BDI-II). This battery will be repeated after 15weeks of
treatment, to evaluate symptom improvement.
Results and conclusions To be announced after 15weeks of treat-
ment course.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW361
Increased levels of oxytocin in adult
OCD patients
F. Mucci∗ Marazziti , S. Baroni , A. Piccinni , G. Massimetti ,
L. Dell’osso
Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale,
Pisa, Italy
∗ Corresponding author.
Introduction The current model of the pathophysiology of
obsessive-compulsive (OCD) is mainly centered on the serotonin
(5-HT) system. However, other pharmacological targets have been
identified, in particular the dopamine and glutamate systems, and
also the neuropeptide oxytocin (OT), both per se and given its inter-
actions with the 5-HT system.
Objectives Given the paucity of information, the present study
aimed at evaluating plasma OT levels in a group on untreated OCD
patients.
Aims The study aimed at evaluating plasma OT levels in a group
of 44 OCD outpatients, as compared with a similar group of healthy
control subjects. On the same time, the relationships between OT
and clinical features and romantic attachment characteristics were
examined as well.
Methods Diagnosis was assessed according to DSM-IV-TR crite-
ria, while the OCD severity was measured by means of the Y-BOCS
rating scale. All patients were drug-free and not depressed. The
romantic attachment was assessed by means of the Italian version
of the “Experiences in Close Relationships” questionnaire. Plasma
OT levels were evaluated by means of a standard RIA kit.
Results The main findings of our study showed that OT levels
were increased in OCD patients, as comparedwith healthy subjects,
and negatively related to symptom severity. Positive relationships
were detected between OT levels and the fearful-avoidant and
dismissing styles of romantic attachments, but only in male OCD
patients.
Conclusions Taken together, these findings suggest that OT may
play a role inOCDpathophysiology and also in romantic attachment
of patients with gender specificity.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW362
Anger is associated with aggressive,
contamination, and sexual obsessions
in severe OCD outpatients
D. Piacentino ∗, M. Pasquini , L. Tarsitani , I. Berardelli ,
V. Roselli , A. Maraone , M. Biondi
1 Sapienza, University of Rome, NESMOS Neuroscience, Mental
Health, and Sensory Organs Department, Rome, Italy
2 Sapienza, University of Rome, Department of Neurology and
Psychiatry, Rome, Italy
∗ Corresponding author.
Introduction Despite the potential theoretical and clinical rele-
vance of psychopathological dimensions in Obsessive-Compulsive
Disorder (OCD), few studies to date have investigated their possible
association with obsession subtypes.
Objectives/Aims We aimed to examine whether, in OCD patients,
anger and other psychopathological dimensions are associated
with specific obsession subtypes.