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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S239

suppression as a principle of exposure and response prevention

(ERP) has a stronger effect on reactive obsessions.

Aims

To compare the effectiveness of two coping strategies

(acceptance and response suppression) on autogenous and reactive

obsessions.

Methods

A total of 164 undergraduate students completed

questionnaires for obsessional thoughts and coping strategies.

According to the most distressing thought, sixty subjects (

n

= 30

with autogenous obsession,

n

= 30 with reactive obsession) were

randomly assigned to two groups differing in treatment conditions.

Individual psychoeducation and practice were performed for four

different groups (2 obsessional subtypes

×

2 coping strategies).

Results

Repeated measure ANOVA demonstrated that the autog-

enous obsessional group showed greater distress reduction

after acceptance treatment than response suppression treatment,

although its effect was not statistically significant. However, the

reactive obsessional group did not show the interaction effect

between distress reduction and the two coping strategies.

Conclusions

The results suggest that coping strategies have dif-

ferential effects on distress reduction of obsessional subtypes.

Different therapeutic approaches may need to be offered to indi-

viduals with autogenous and reactive obsessions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.477

EW360

Adjuvant treatment of resistant

obsessive-compulsive disorder with

memantine: A case report

D. Mota

1 , 2 ,

, A. Oliveira

1 , 2

, J. Silva

1

, M. Fernandes

1

, J. Ribeiro

1

,

V. Martins

1

, F. Duarte

1

, M. Marques

1 , 2

, A.T. Pereira

1 , 2

,

J. Andrade

1 , 2

, A.F. Macedo

1 , 2

1

Centro Hospitalar e Universitario de Coimbra, CRI de Psiquiatria e

Saúde Mental, Coimbra, Portugal

2

Faculty of Medicine, University of Coimbra, Department of Medical

Psychology, Coimbra, Portugal

Corresponding author.

Introduction

OCD could be a very disabling condition, imply-

ing severe impairment of social and occupational functioning

and decreased quality of life. OCD is treated with a combination

of psychopharmacological treatments and cognitive-behavioural

therapy. Clomipramine was the first anti-obsessive drug, and was

followed by selective serotonin re-uptake inhibitors (SSRIs), both

modulating serotoninergic transmission. Low dose atypical anti-

psychotic are sometimes used to potentiate serotoninergic agents.

Growing evidence based on animal models and on neuroimaging

shows that glutamatergic transmission could play an important

role in the aetiology of OCD. Therefore, glutamate modulators such

as N-methyl-D-aspartate (NMDA) receptor antagonists became the

focus of the search of novel treatments for OCD. One of this drugs,

memantine, already approved for Alzheimer disease treatment,

was used off-label the first time ten years ago in resistant case

of OCD with positive results. Besides some further successful case

reports, there are a single-blind case control study and a cou-

ple of randomized, double-blind, placebo-controlled trials showing

improvement of OCD symptoms with memantine adjuvant phar-

macotherapy.

Objectives and aims

To describe a case report of off-label treat-

ment of a severe resistant case of OCD with memantine, after

15weeks of treatment.

Methods

Literature review and case description. Before begin-

ning treatment with memantine, the patient made a psychological

assessement (baseline) with a battery of tests (MINI Plus, Y-BOCS,

QPP-15, WDQ, ECPAD, OP2, OAS2, MPS-H&F, MPS-F, HEXACO-PI-

R, MOCI, BDI-II). This battery will be repeated after 15weeks of

treatment, to evaluate symptom improvement.

Results and conclusions

To be announced after 15weeks of treat-

ment course.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.478

EW361

Increased levels of oxytocin in adult

OCD patients

F. Mucci

, D.

Marazziti , S. Baroni , A. Piccinni , G. Massimetti ,

L. Dell’osso

Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale,

Pisa, Italy

Corresponding author.

Introduction

The current model of the pathophysiology of

obsessive-compulsive (OCD) is mainly centered on the serotonin

(5-HT) system. However, other pharmacological targets have been

identified, in particular the dopamine and glutamate systems, and

also the neuropeptide oxytocin (OT), both per se and given its inter-

actions with the 5-HT system.

Objectives

Given the paucity of information, the present study

aimed at evaluating plasma OT levels in a group on untreated OCD

patients.

Aims

The study aimed at evaluating plasma OT levels in a group

of 44 OCD outpatients, as compared with a similar group of healthy

control subjects. On the same time, the relationships between OT

and clinical features and romantic attachment characteristics were

examined as well.

Methods

Diagnosis was assessed according to DSM-IV-TR crite-

ria, while the OCD severity was measured by means of the Y-BOCS

rating scale. All patients were drug-free and not depressed. The

romantic attachment was assessed by means of the Italian version

of the “Experiences in Close Relationships” questionnaire. Plasma

OT levels were evaluated by means of a standard RIA kit.

Results

The main findings of our study showed that OT levels

were increased in OCD patients, as comparedwith healthy subjects,

and negatively related to symptom severity. Positive relationships

were detected between OT levels and the fearful-avoidant and

dismissing styles of romantic attachments, but only in male OCD

patients.

Conclusions

Taken together, these findings suggest that OT may

play a role inOCDpathophysiology and also in romantic attachment

of patients with gender specificity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.479

EW362

Anger is associated with aggressive,

contamination, and sexual obsessions

in severe OCD outpatients

D. Piacentino

1 ,

, M. Pasquini

2

, L. Tarsitani

2

, I. Berardelli

2

,

V. Roselli

2

, A. Maraone

2

, M. Biondi

2

1

Sapienza, University of Rome, NESMOS Neuroscience, Mental

Health, and Sensory Organs Department, Rome, Italy

2

Sapienza, University of Rome, Department of Neurology and

Psychiatry, Rome, Italy

Corresponding author.

Introduction

Despite the potential theoretical and clinical rele-

vance of psychopathological dimensions in Obsessive-Compulsive

Disorder (OCD), few studies to date have investigated their possible

association with obsession subtypes.

Objectives/Aims

We aimed to examine whether, in OCD patients,

anger and other psychopathological dimensions are associated

with specific obsession subtypes.