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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S241

Introduction

Group Cognitive Behavioural Therapy (GCBT) is a

cost-effective modality of treatment alternative to individual Cog-

nitive Behavioural Therapy (CBT). Despite several well-controlled

trials demonstrated the efficacy of GCBT for Obsessive Compulsive

Disorder (OCD), few studies evaluated the effectiveness of GCBT on

outpatients attending routinary psychiatric services, and in Italy

this topic appears understudied.

Objectives

The current study evaluated the effectiveness of a

GCBT protocol on OCD symptoms and comorbid depression and

anxiety in a group of outpatients attending a psychiatric service in

Italy.

Method

Twenty outpatients with a diagnosis of OCD were

included in the study and received 20 sessions of GCBT, con-

sisting of psychoeducation on anxiety and OCD, relaxation

training, in vivo/imaginal exposure and response prevention, cog-

nitive restructuring for obsessive beliefs, cognitive defusion, and

assertiveness training. The Yale-BrownObsessive Compulsive Scale

(Y-BOCS), Beck Depression Inventory (BDI-II), Beck Anxiety Inven-

tory (BAI) were administered at pre- and post-treatment.

Results

Two outpatients had a comorbid bipolar disorder, eight

had a concurrent personality disorder. Ten outpatients were

on concurrent antidepressants, five on antipsychotics. Three

outpatients prematurely dropped out fromtreatment. Among com-

pleters, GCBT produced significant changes on OCD symptoms,

anxiety and depression frompre- to post-treatment. The GCBT pro-

tocol was feasible and the outpatients reported high satisfaction

judgements.

Conclusions

Future studies should investigate clinical predictors

of best response after GCBT and assess maintenance of symptom

changes at long-term follow-up.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.483

EW366

Cognitive behavioral therapy in

pharmacoresistant

obsessive-compulsive disorder

J. Vyskocilova

1

, J. Prasko

2 ,

1

Charles University Prague, Faculty of Humanities, Prague, Czech

Republic

2

University Hospital Olomouc, Faculty of Medicine and Dentistry,

University Palacky Olomouc, Department of Psychiatry, Olomouc,

Czech Republic

Corresponding author.

Background

The aim of the study was to determine whether

patients with OCD resistant to drugs may improve using inten-

sive, systematic CBT lasting six weeks and whether it is possible

to predict the therapeutic effect using demographic, clinical and

psychological characteristics at baseline.

Method

Therewere 66 patients included in the study. Fifty-seven

patients completed the program. The diagnosis was confirmed

by a structured interview MINI. Patient were rated before the

treatment using Y-BOCS (objective and subjective form), CGI

(objective and subjective form), BAI, BDI, DES (Dissociative Expe-

riences Scale), SDQ 20 (Somatoform Dissociation Questionnaire),

and SDS (Sheehan Disability Scale), and at the end of the treat-

ment using subjective Y-BOCS, objective and subjective CGI, BAI,

and BDI. Patients were treated with antidepressants and daily

intensive group cognitive behavioral therapy for the period of

six weeks.

Results

During the 6-week intensive cognitive behavioral ther-

apy program in combination with pharmacotherapy, there was a

significant improvement in patients suffering from OCD formerly

resistant to pharmacotherapy. There were statistically significant

decreases in the scales assessing the severity of OCD symptoms,

anxiety, and depressive feelings. The lower treatment effect was

achieved specifically in patients who:

– showed fewer OCD themes in symptomatology;

– showed a higher level of somatoform dissociation;

– with poor insight;

– with a higher level of overall severity of the disorder in the begin-

ning.

The remission of the disorder was achieved more probably in

patients with:

– good insight;

– the lower level of initial anxiety;

– without comorbidity with the depressive disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.484

EW367

Investigation of affective

temperaments and chronobiology in

patients with obsessive-compulsive

disorder

A. Sakalli Kani

1 ,

, C. Aksoy Poyraz

2

, B.C. Poyraz

2

, M.R. Bayar

2

1

Sivas Numune State Hospital, Psychiatry, Sivas, Turkey

2

Istanbul University, Medical School of Cerrahpasa, Psychiatry,

Istanbul, Turkey

Corresponding author.

Introduction

Comorbid mood disorders affect negatively the

prognosis of obsessive-compulsive disorder (OCD). Affective tem-

peraments are assumed to be subsyndromal symptoms and

precursors of mood disorders but its effects on OCD outcome

remain unclear. There is a body of evidence, which supports the

association between circadian rhythm disturbances and mood dis-

orders in literature. In contrast, there is limited data concerning

the effects of chronobiological preference among the patients with

OCD and OCD comorbid mood disorders.

Objective

The aim of this study is to assess the clinical effects

of affective temperaments and chronotype differences in patients

with OCD.

Methods

The research was performed in patients with OCD

which have been under treatment at least for 12weeks (

n

= 76) and

healthy controls (

n

= 55). Yale Brown Obsession Compulsion Scale,

TEMPS-A, Morningness and Eveningness Questionnaire, Hamilton

Anxiety Rating Scale and Hamilton Depression Rating Scale were

used in the study.

Results

There were higher scores in depressive, cyclothymic,

irritable and anxious temperaments in patients with OCD com-

pared to the healthy group. There were significant differences

between patients with remission and not remission in depres-

sive, cyclothymic, irritable and anxious temperaments. Compared

to healthy group eveningness chronotype was more frequent in

patients; however the difference was not statistically significant.

The OCD patients did not differ from comorbid anxiety, depression

and remission levels according to the chronotype.

Conclusion

Understanding the effects of affective temperaments

and chronotype differences on the outcome of patients with OCD,

may provide developing new treatment approaches in especially

treatment resistant OCD patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.485