European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S241
Introduction Group Cognitive Behavioural Therapy (GCBT) is a
cost-effective modality of treatment alternative to individual Cog-
nitive Behavioural Therapy (CBT). Despite several well-controlled
trials demonstrated the efficacy of GCBT for Obsessive Compulsive
Disorder (OCD), few studies evaluated the effectiveness of GCBT on
outpatients attending routinary psychiatric services, and in Italy
this topic appears understudied.
Objectives The current study evaluated the effectiveness of a
GCBT protocol on OCD symptoms and comorbid depression and
anxiety in a group of outpatients attending a psychiatric service in
Italy.
Method Twenty outpatients with a diagnosis of OCD were
included in the study and received 20 sessions of GCBT, con-
sisting of psychoeducation on anxiety and OCD, relaxation
training, in vivo/imaginal exposure and response prevention, cog-
nitive restructuring for obsessive beliefs, cognitive defusion, and
assertiveness training. The Yale-BrownObsessive Compulsive Scale
(Y-BOCS), Beck Depression Inventory (BDI-II), Beck Anxiety Inven-
tory (BAI) were administered at pre- and post-treatment.
Results Two outpatients had a comorbid bipolar disorder, eight
had a concurrent personality disorder. Ten outpatients were
on concurrent antidepressants, five on antipsychotics. Three
outpatients prematurely dropped out fromtreatment. Among com-
pleters, GCBT produced significant changes on OCD symptoms,
anxiety and depression frompre- to post-treatment. The GCBT pro-
tocol was feasible and the outpatients reported high satisfaction
judgements.
Conclusions Future studies should investigate clinical predictors
of best response after GCBT and assess maintenance of symptom
changes at long-term follow-up.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW366
Cognitive behavioral therapy in
pharmacoresistant
obsessive-compulsive disorder
J. Vyskocilova , J. Prasko ∗
1 Charles University Prague, Faculty of Humanities, Prague, Czech
Republic
2 University Hospital Olomouc, Faculty of Medicine and Dentistry,
University Palacky Olomouc, Department of Psychiatry, Olomouc,
Czech Republic
∗ Corresponding author.
Background The aim of the study was to determine whether
patients with OCD resistant to drugs may improve using inten-
sive, systematic CBT lasting six weeks and whether it is possible
to predict the therapeutic effect using demographic, clinical and
psychological characteristics at baseline.
Method Therewere 66 patients included in the study. Fifty-seven
patients completed the program. The diagnosis was confirmed
by a structured interview MINI. Patient were rated before the
treatment using Y-BOCS (objective and subjective form), CGI
(objective and subjective form), BAI, BDI, DES (Dissociative Expe-
riences Scale), SDQ 20 (Somatoform Dissociation Questionnaire),
and SDS (Sheehan Disability Scale), and at the end of the treat-
ment using subjective Y-BOCS, objective and subjective CGI, BAI,
and BDI. Patients were treated with antidepressants and daily
intensive group cognitive behavioral therapy for the period of
six weeks.
Results During the 6-week intensive cognitive behavioral ther-
apy program in combination with pharmacotherapy, there was a
significant improvement in patients suffering from OCD formerly
resistant to pharmacotherapy. There were statistically significant
decreases in the scales assessing the severity of OCD symptoms,
anxiety, and depressive feelings. The lower treatment effect was
achieved specifically in patients who:
– showed fewer OCD themes in symptomatology;
– showed a higher level of somatoform dissociation;
– with poor insight;
– with a higher level of overall severity of the disorder in the begin-
ning.
The remission of the disorder was achieved more probably in
patients with:
– good insight;
– the lower level of initial anxiety;
– without comorbidity with the depressive disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW367
Investigation of affective
temperaments and chronobiology in
patients with obsessive-compulsive
disorder
A. Sakalli Kani ∗, C. Aksoy Poyraz , B.C. Poyraz , M.R. Bayar
1 Sivas Numune State Hospital, Psychiatry, Sivas, Turkey
2 Istanbul University, Medical School of Cerrahpasa, Psychiatry,
Istanbul, Turkey
∗ Corresponding author.
Introduction Comorbid mood disorders affect negatively the
prognosis of obsessive-compulsive disorder (OCD). Affective tem-
peraments are assumed to be subsyndromal symptoms and
precursors of mood disorders but its effects on OCD outcome
remain unclear. There is a body of evidence, which supports the
association between circadian rhythm disturbances and mood dis-
orders in literature. In contrast, there is limited data concerning
the effects of chronobiological preference among the patients with
OCD and OCD comorbid mood disorders.
Objective The aim of this study is to assess the clinical effects
of affective temperaments and chronotype differences in patients
with OCD.
Methods The research was performed in patients with OCD
which have been under treatment at least for 12weeks (n = 76) and
healthy controls (n = 55). Yale Brown Obsession Compulsion Scale,
TEMPS-A, Morningness and Eveningness Questionnaire, Hamilton
Anxiety Rating Scale and Hamilton Depression Rating Scale were
used in the study.
Results There were higher scores in depressive, cyclothymic,
irritable and anxious temperaments in patients with OCD com-
pared to the healthy group. There were significant differences
between patients with remission and not remission in depres-
sive, cyclothymic, irritable and anxious temperaments. Compared
to healthy group eveningness chronotype was more frequent in
patients; however the difference was not statistically significant.
The OCD patients did not differ from comorbid anxiety, depression
and remission levels according to the chronotype.
Conclusion Understanding the effects of affective temperaments
and chronotype differences on the outcome of patients with OCD,
may provide developing new treatment approaches in especially
treatment resistant OCD patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.