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S236

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

negative correlation between [

11

C]PIB SUVR and [

11

C]MeQAA BP

ND

in the nucleus basalis ofMynert (NBM). TheNBM[

11

C]PIB SUVRwas

negatively correlated with the [

11

C]MeQAA BP

ND

level in the ante-

rior and posterior cingulate cortices, whereas the relation within

the same region showed weak correlation. Also we found signifi-

cant correlation between cognitive decline and [

11

C]MeQAA BP

ND

levels in the NBM.

Conclusions

A deposition-linked 7-nAChR dysfunction may

account for cognitive decline in AD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.468

EW351

Caudate neurochemistry in

unmedicated obsessive-compulsive

disorder patients: A magnetic

resonance spectroscopy study

A. Parmar

1 ,

, P. Sharan

1

, S. Khanelwal

1

, U. Sharma

2

,

N. Jagannathan

2

1

All India Institute of Medical Sciences, Department of Psychiatry,

Delhi, India

2

All India Institute of Medical Sciences, Department of NMR and MRI

facility, Delhi, India

Corresponding author.

Introduction

Caudate nucleus has widely regarded as having

a central role in the neurobiology of obsessive-compulsive dis-

order (OCD). Magnetic resonance spectroscopy (MRS) provides

in vivo assessment of brain neurochemistry. Previous studies sug-

gest changes in levels of N-acetyl aspartate (NAA) and Glx levels

(Glutamate + Glutamine) in patients with OCD.

Aims and objectives

To measure levels of NAA, Choline (tCho),

myo-inositol (mI), Glx and total creatine (tCr) in unmedicated OCD

patients and compare them with healthy controls.

Methods

We included 28 subjects diagnosed as OCD (DSM-IV)

with total duration of illness < 5 years who were not on any specific

treatment for OCD for last 8weeks and were free from other axis-I

psychiatric disorders. Twenty-six subjects without any axis-I diag-

nosis were included in group of healthy controls. MRS was done on

a 3-Tesla MRI scanner. Absolute measures of neurochemicals were

assessed using LC model software.

Results

Although there were no significant differences between

OCD patients and healthy controls, NAA levels were lower and Glx

level were higher in patients with OCD at a trend level. Levels of mI

positively correlated with disease severity (on YBOCS scale).

Discussion

Our result of decreased NAA and increased Glx in cau-

date nucleus is in line with the previous studies although failure to

reach significance can be explained by the fact that we included rel-

atively non chronic patients as compared to most previous studies.

Conclusions

Our findings suggest impaired neuronal density

(decreased NAA) and hypergutaminergic state (increased Glx) in

caudate nucleus of patients with OCD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.469

EW352

3-dimensional evaluation of lateral

ventricle volumes of schizophrenia

patients and investigation of the

subgroups

I. Polat Nazli

1 ,

, M. Atlamaz

1

, O. Ozalay

2

, F. Deger

3

, O. Kitis

4

,

A.S. Gonul

1

1

Ege University School of Medicine, Psychiatry, Izmir, Turkey

2

Ege University, Institute of Health Sciences, Izmir, Turkey

3

Ege University, Sociology, Izmir, Turkey

4

Ege University School of Medicine, Radiology, Izmir, Turkey

Corresponding author.

Introduction

The thought of greater loss of brain tissue in Deficit

Syndrome (DS) i.e. subgroup of schizophrenia with enduring pri-

mary negative symptoms defined by Carpenter et al.; this has not

been verified by recent studies.

Objective

Accumulated researches suggest that enlargement in

Lateral Ventricles (LV) is related with current negative symptoms

and poor prognosis. However, this has not been validated in DS.

Aims

Our aim is to study the association between the enduring

negative symptoms and LV changes schizophrenia. We included

both deficit and non-deficit patients for comparison with controls.

Methods

Forty-five patients (18 DS, 27 non-DS) and 37 healthy

controls were recruited, evaluated for positive and negative

symptoms, depression and extrapyramidal symptoms. Structural

magnetic resonance imaging was performed. LV was assessed by

MANCOVA (gender, age total brain volume as confounding fac-

tors) in 3-dimensional (3D) shape analyses. Correlations between

clinical and imaging data were analyzed by Pearson correlation

coefficient;

P

> 0.05 being significant.

Results

LV of patientswas found to be greater than controls, espe-

cially in regions adjacent to parietal and temporal regions but no

significant difference between subgroups was detected. Enlarge-

ment in right LV by corpus callosum adjacency was found in DS.

There was no correlation between negative symptoms and LV vol-

ume.

Conclusions

The idea of greater amount of LV enlargement

in patients with predominant negative symptoms could not be

observed in 3D analyses. New pathophysiological theories are

needed for the explanation of negative symptoms, loss of function-

ing and poor prognosis rather than only commenting about tissue

decrease/loss.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.470

EW353

Schizophrenia and dementia.

Morphological and spectroscopic

findings. Baseline data

A. San Román Uría

1 ,

, J.Á. Monforte Porto

1

, L. Santirso Abuelbar

2

,

J. Chaviano Grajera

2

, M.Á. Martín Pérez

2

, J.A. Alcalá Due˜nas

3

,

V.A. Cuéllar Leal

4

1

Complejo Asistencial de Zamora, Hospital Provincial de Zamora,

Servicio de Psiquiatría, Zamora, Spain

2

Complejo Asistencial de Zamora, Hospital Virgen de la Concha,

Servicio de Radiodiagnóstico, Zamora, Spain

3

Unidad de Rehabilitación Psiquiátrica, Secretaría de Salud de Nuevo

León, Monterrey, Mexico

4

Unidad de Rehabilitación Psiquiátrica, Secretaría de Salud de Nuevo

León, Universidad de Monterrey, Monterrey, Mexico

Corresponding author.

Introduction

Spectroscopy is a diagnostic method using MRI, to

analysis tissue in vivo noninvasively. There are several studies

with magnetic resonance spectroscopy (MRS) in patients with psy-

chiatric disorders, especially schizophrenia and Alzheimer’s type

dementia, in their different developmental stage. Sometimes spec-

troscopy may allow brain metabolic changes to be observed before

the onset of alterations in brain parenchyma. We do not know

any documented case of spectroscopy performed on a psychiatry-

targeted manner on our hospital. It is a noninvasive technique

without added cost to the MRI and is available in our hospital. It

seems interesting for us to combine two specialties like radiology

and psychiatry in the field of a neuroimaging Project.

Objectives and aims

Our goal is try to establish a radiological

anatomical correlate to brain molecular levels. It’s a transverse and