European Psychiatry - Volume 33 - March 2016

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S236 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
negative correlation between [11C]PIB SUVR and [11C]MeQAA BPND
in the nucleus basalis ofMynert (NBM). TheNBM[11C]PIB SUVRwas
negatively correlated with the [11C]MeQAA BPND level in the ante-
rior and posterior cingulate cortices, whereas the relation within
the same region showed weak correlation. Also we found signifi-
cant correlation between cognitive decline and [11C]MeQAA BP ND
levels in the NBM.
Conclusions A deposition-linked 7-nAChR dysfunction may
account for cognitive decline in AD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW351
Caudate neurochemistry in
unmedicated obsessive-compulsive
disorder patients: A magnetic
resonance spectroscopy study
A. Parmar ∗, P. Sharan , S. Khanelwal , U. Sharma ,
N. Jagannathan
1 All India Institute of Medical Sciences, Department of Psychiatry,
Delhi, India
2 All India Institute of Medical Sciences, Department of NMR and MRI
facility, Delhi, India
∗ Corresponding author.
Introduction Caudate nucleus has widely regarded as having
a central role in the neurobiology of obsessive-compulsive dis-
order (OCD). Magnetic resonance spectroscopy (MRS) provides
in vivo assessment of brain neurochemistry. Previous studies sug-
gest changes in levels of N-acetyl aspartate (NAA) and Glx levels
(Glutamate + Glutamine) in patients with OCD.
Aims and objectives To measure levels of NAA, Choline (tCho),
myo-inositol (mI), Glx and total creatine (tCr) in unmedicated OCD
patients and compare them with healthy controls.
Methods We included 28 subjects diagnosed as OCD (DSM-IV)
with total duration of illness < 5 years who were not on any specific
treatment for OCD for last 8weeks and were free from other axis-I
psychiatric disorders. Twenty-six subjects without any axis-I diag-
nosis were included in group of healthy controls. MRS was done on
a 3-Tesla MRI scanner. Absolute measures of neurochemicals were
assessed using LC model software.
Results Although there were no significant differences between
OCD patients and healthy controls, NAA levels were lower and Glx
level were higher in patients with OCD at a trend level. Levels of mI
positively correlated with disease severity (on YBOCS scale).
Discussion Our result of decreased NAA and increased Glx in cau-
date nucleus is in line with the previous studies although failure to
reach significance can be explained by the fact that we included rel-
atively non chronic patients as compared to most previous studies.
Conclusions Our findings suggest impaired neuronal density
(decreased NAA) and hypergutaminergic state (increased Glx) in
caudate nucleus of patients with OCD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW352
3-dimensional evaluation of lateral
ventricle volumes of schizophrenia
patients and investigation of the
subgroups
I. Polat Nazli ∗, M. Atlamaz , O. Ozalay , F. Deger , O. Kitis ,
A.S. Gonul
1 Ege University School of Medicine, Psychiatry, Izmir, Turkey
2 Ege University, Institute of Health Sciences, Izmir, Turkey
3 Ege University, Sociology, Izmir, Turkey
4 Ege University School of Medicine, Radiology, Izmir, Turkey
∗ Corresponding author.
Introduction The thought of greater loss of brain tissue in Deficit
Syndrome (DS) i.e. subgroup of schizophrenia with enduring pri-
mary negative symptoms defined by Carpenter et al.; this has not
been verified by recent studies.
Objective Accumulated researches suggest that enlargement in
Lateral Ventricles (LV) is related with current negative symptoms
and poor prognosis. However, this has not been validated in DS.
Aims Our aim is to study the association between the enduring
negative symptoms and LV changes schizophrenia. We included
both deficit and non-deficit patients for comparison with controls.
Methods Forty-five patients (18 DS, 27 non-DS) and 37 healthy
controls were recruited, evaluated for positive and negative
symptoms, depression and extrapyramidal symptoms. Structural
magnetic resonance imaging was performed. LV was assessed by
MANCOVA (gender, age total brain volume as confounding fac-
tors) in 3-dimensional (3D) shape analyses. Correlations between
clinical and imaging data were analyzed by Pearson correlation
coefficient; P > 0.05 being significant.
Results LV of patientswas found to be greater than controls, espe-
cially in regions adjacent to parietal and temporal regions but no
significant difference between subgroups was detected. Enlarge-
ment in right LV by corpus callosum adjacency was found in DS.
There was no correlation between negative symptoms and LV vol-
ume.
Conclusions The idea of greater amount of LV enlargement
in patients with predominant negative symptoms could not be
observed in 3D analyses. New pathophysiological theories are
needed for the explanation of negative symptoms, loss of function-
ing and poor prognosis rather than only commenting about tissue
decrease/loss.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW353
Schizophrenia and dementia.
Morphological and spectroscopic
findings. Baseline data
A. San Román Uría ∗, J.Á. Monforte Porto , L. Santirso Abuelbar ,
J. Chaviano Grajera , M.Á. Martín Pérez , J.A. Alcalá Due˜nas ,
V.A. Cuéllar Leal
1 Complejo Asistencial de Zamora, Hospital Provincial de Zamora,
Servicio de Psiquiatría, Zamora, Spain
2 Complejo Asistencial de Zamora, Hospital Virgen de la Concha,
Servicio de Radiodiagnóstico, Zamora, Spain
3 Unidad de Rehabilitación Psiquiátrica, Secretaría de Salud de Nuevo
León, Monterrey, Mexico
4 Unidad de Rehabilitación Psiquiátrica, Secretaría de Salud de Nuevo
León, Universidad de Monterrey, Monterrey, Mexico
∗ Corresponding author.
Introduction Spectroscopy is a diagnostic method using MRI, to
analysis tissue in vivo noninvasively. There are several studies
with magnetic resonance spectroscopy (MRS) in patients with psy-
chiatric disorders, especially schizophrenia and Alzheimer’s type
dementia, in their different developmental stage. Sometimes spec-
troscopy may allow brain metabolic changes to be observed before
the onset of alterations in brain parenchyma. We do not know
any documented case of spectroscopy performed on a psychiatry-
targeted manner on our hospital. It is a noninvasive technique
without added cost to the MRI and is available in our hospital. It
seems interesting for us to combine two specialties like radiology
and psychiatry in the field of a neuroimaging Project.
Objectives and aims Our goal is try to establish a radiological
anatomical correlate to brain molecular levels. It’s a transverse and