European Psychiatry - Volume 33 - March 2016

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S238 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
2 Timisoara Psychiatric Clinic, Psychiatry, Timisoara, Romania
∗ Corresponding author.
Introduction The co-occurrence between obsessive-compulsive
and schizophrenic symptomsmay reflect comorbidity between two
different disorders, a schizo-obsessive form of schizophrenia, or a
single schizo-obsessive disorder.
Objectives The purpose of the study is to identify if patients
with obsessive-compulsive disorder comorbid with schizophrenia
(OCD-SCZ) have different behavioral phenotypes compared with
patients with obsessive-compulsive disorder (OCD).
Methods The study was carried out on patients diagnosed with
OCD with or without comorbidity with schizophrenia. The fol-
lowing data was analyzed: socio-demographic parameters, family
psychiatric history, and behavioral phenotypes such as nicotine,
alcohol and illicit drug abuse, hetero-aggressivity, and suicidal
attempts.
Results The OCD-SCZ sample included 30 patients, and the OCD
sample 31 patients. In theOCD-SCZ sample, themean agewas 39.83
(SD = 13.6) years, and there were 13 (43.3%) men and 17 (56.7%)
women. In the OCD sample, the mean age was 44.29 (SD = 13.55)
years and there were 11 (35.5%) males and 20 (64.5%) females. The
OCD-SCZ sample had significantly higher rates of suicidal attempts
(U = 356, Z =−2.83, P = 0.005) and episodes of hetero-aggressivity
(U = 355.5, Z= −2.37, P = 0.01) than the OCD sample. Moreover, the
patients with OCD-SCZ presented significantly more recorded vio-
lence, substance abuse and personality disorders in their family of
origin ( U = 275, Z = −3.19, P = 0.001). We found no statistically sig-
nificant differences between the two samples regarding nicotine,
alcohol or illicit drug abuse.
Conclusions The patients with OCD associated with schizophre-
nia presented significantly more suicidal attempts, episodes of
hetero-aggressivity, and have more recorded violence, substance
abuse and personality disorders in their family history.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW357
Neuroimaging correlates of insight in
obsessive compulsive disorder: A fMRI
study
A. Gadad ∗, D.Y.C.J. Reddy , D.G. Venkatasubramanian , D.J. C.N.
National Institute of Mental Health & Neurosciences, Psychiatry,
Bangalore, India
∗ Corresponding author.
Aim of the study To study the neural substrates of insight in OCD
by comparing patients with good insight, patients with poor insight
and matched healthy controls using functional MRI.
Methodology Subjects were recruited from among patients
attending OCD clinic, adult psychiatry services and psychiatry
ward inpatients of National Institute of Mental Health And Neu-
rosciences (NIMHANS), Bangalore. They were further divided into
‘good insight’ (n = 30) and ‘poor insight’ (n = 14) using Brown’s
assessment of belief’s scale. Control subjects (n = 30) were recruited
from consenting volunteers. 3 T MRI was used, mental rotation task
was paradigm used for fMRI and analysis was done by SPM 8.
Results Poor insight patients and Ggood insight patients compar-
ison revealed differential activation in Left superior/Medial frontal
gyrus (corresponding to theDLPFC). Anegative correlation between
BABS score and activation of right inferior parietal lobule. Men-
tal Rotation task behavioural data results: OCD patients as a group
had significantly lower accuracy compared tohealthy controls. Poor
insight group had significantly decreased accuracy ratio compared
to Good insight group and healthy controls. A negative correlation
was noted between BABS score and accuracy ratio, indicating that
poorer the insight, greater the errors during the active task.
Conclusion Insight has been important prognostic factor in OCD.
Poor insight patients had specific deficits in left medial frontal
gyrus and right inferior parietal lobule as compared to good insight
patients and healthy controls. Together, these indicate that insight
has a strong neurobiological underpinning in OCD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW358
Atomoxetine for hoarding disorder:
A preclinical and clinical investigation
G. Grassi∗, L. Micheli , L. Di Cesare Mannelli , E. Compagno ,
C. Ghelardini , S. Pallanti
University of Florence, NEUROFARBA, Florence, Italy
∗ Corresponding author.
Aim Despite some studies suggested that childhood attention-
deficit hyperactivity disorder (ADHD) and inattention symptoms
may be related to hoarding, only a small case series study investi-
gated the effectiveness of ADHD medications in hoarding disorder.
The aim of the present study was to evaluate the preclinical and
clinical effectiveness of atomoxetine, a noradrenaline reuptake
inhibitor approved for childhood and adulthood ADHD, in an ani-
mal model of compulsive-like behaviors (marble burying test) and
in patients with a primary diagnosis of hoarding disorder.
Methods We performed a preclinical investigation assessing the
effects of atomoxetine on the marble burying behavior test in mice.
The number of marbles buried in vehicle and atomoxetine treated
groupswasmeasured. Subsequently, we conducted a clinical inves-
tigation on five patients fulfilling the DSM-5 criteria for hoarding
disorder. These patients were treatedwith atomoxetine 40–100mg
for 12weeks. Full response was defined as a more of 35% decrease
in UCLA Hoarding Severity Scale (UHSS) and partial response was
defined as a more of 25% decrease in UHSS scale.
Results Atomoxetine significantly reduced the number of buried
marbles in a dose dependent manner in comparison to control
mice, without affecting the locomotor activity. Three out of five
atomoxetine-treated patientswere classified as full responders and
two patients as partial responders after 12weeks of treatment.
Conclusions These preclinical and clinical data suggest that ato-
moxetine may be considered as a potentially effective compound
for hoarding disorder and therefore should be considered for future
controlled trials in hoarding disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW359
Differential effects of coping
strategies on autogenous and reactive
obsessions
M.S. Lee ∗, S.M. Kwon
1 Seoul National University Hospital, Department of Psychiatry,
Seoul, Korea
2 Seoul National University, Department of Psychology, Seoul, Korea
∗ Corresponding author.
Introduction Obsessive thoughts can be categorized into two sub-
types, autogenous obsessions and reactive obsessions. Although it
has been investigated that each subtype associates with different
maladaptive coping strategies, no studies have yet empirically com-
pared the effectiveness of adaptive coping strategies on autogenous
and reactive obsessions.
Objectives It is hypothesized that acceptance, which is a core
therapeutic principle of acceptance-based cognitive therapy (ACT),
is more effective on autogenous obsessions, whereas response