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S238

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

2

Timisoara Psychiatric Clinic, Psychiatry, Timisoara, Romania

Corresponding author.

Introduction

The co-occurrence between obsessive-compulsive

and schizophrenic symptomsmay reflect comorbidity between two

different disorders, a schizo-obsessive form of schizophrenia, or a

single schizo-obsessive disorder.

Objectives

The purpose of the study is to identify if patients

with obsessive-compulsive disorder comorbid with schizophrenia

(OCD-SCZ) have different behavioral phenotypes compared with

patients with obsessive-compulsive disorder (OCD).

Methods

The study was carried out on patients diagnosed with

OCD with or without comorbidity with schizophrenia. The fol-

lowing data was analyzed: socio-demographic parameters, family

psychiatric history, and behavioral phenotypes such as nicotine,

alcohol and illicit drug abuse, hetero-aggressivity, and suicidal

attempts.

Results

The OCD-SCZ sample included 30 patients, and the OCD

sample 31 patients. In theOCD-SCZ sample, themean agewas 39.83

(SD = 13.6) years, and there were 13 (43.3%) men and 17 (56.7%)

women. In the OCD sample, the mean age was 44.29 (SD = 13.55)

years and there were 11 (35.5%) males and 20 (64.5%) females. The

OCD-SCZ sample had significantly higher rates of suicidal attempts

(

U

= 356,

Z

=

2.83,

P

= 0.005) and episodes of hetero-aggressivity

(

U

= 355.5,

Z

=

2.37,

P

= 0.01) than the OCD sample. Moreover, the

patients with OCD-SCZ presented significantly more recorded vio-

lence, substance abuse and personality disorders in their family of

origin (

U

= 275,

Z

=

3.19,

P

= 0.001). We found no statistically sig-

nificant differences between the two samples regarding nicotine,

alcohol or illicit drug abuse.

Conclusions

The patients with OCD associated with schizophre-

nia presented significantly more suicidal attempts, episodes of

hetero-aggressivity, and have more recorded violence, substance

abuse and personality disorders in their family history.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.474

EW357

Neuroimaging correlates of insight in

obsessive compulsive disorder: A fMRI

study

A. Gadad

, D.Y.C.J. Reddy , D.G. Venkatasubramanian , D.J. C.N.

National Institute of Mental Health & Neurosciences, Psychiatry,

Bangalore, India

Corresponding author.

Aim of the study

To study the neural substrates of insight in OCD

by comparing patients with good insight, patients with poor insight

and matched healthy controls using functional MRI.

Methodology

Subjects were recruited from among patients

attending OCD clinic, adult psychiatry services and psychiatry

ward inpatients of National Institute of Mental Health And Neu-

rosciences (NIMHANS), Bangalore. They were further divided into

‘good insight’ (

n

= 30) and ‘poor insight’ (

n

= 14) using Brown’s

assessment of belief’s scale. Control subjects (

n

= 30) were recruited

from consenting volunteers. 3 T MRI was used, mental rotation task

was paradigm used for fMRI and analysis was done by SPM 8.

Results

Poor insight patients and Ggood insight patients compar-

ison revealed differential activation in Left superior/Medial frontal

gyrus (corresponding to theDLPFC). Anegative correlation between

BABS score and activation of right inferior parietal lobule. Men-

tal Rotation task behavioural data results: OCD patients as a group

had significantly lower accuracy compared tohealthy controls. Poor

insight group had significantly decreased accuracy ratio compared

to Good insight group and healthy controls. A negative correlation

was noted between BABS score and accuracy ratio, indicating that

poorer the insight, greater the errors during the active task.

Conclusion

Insight has been important prognostic factor in OCD.

Poor insight patients had specific deficits in left medial frontal

gyrus and right inferior parietal lobule as compared to good insight

patients and healthy controls. Together, these indicate that insight

has a strong neurobiological underpinning in OCD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.475

EW358

Atomoxetine for hoarding disorder:

A preclinical and clinical investigation

G. Grassi

, L. Micheli , L. Di Cesare Mannelli , E. Compagno ,

C. Ghelardini , S. Pallanti

University of Florence, NEUROFARBA, Florence, Italy

Corresponding author.

Aim

Despite some studies suggested that childhood attention-

deficit hyperactivity disorder (ADHD) and inattention symptoms

may be related to hoarding, only a small case series study investi-

gated the effectiveness of ADHD medications in hoarding disorder.

The aim of the present study was to evaluate the preclinical and

clinical effectiveness of atomoxetine, a noradrenaline reuptake

inhibitor approved for childhood and adulthood ADHD, in an ani-

mal model of compulsive-like behaviors (marble burying test) and

in patients with a primary diagnosis of hoarding disorder.

Methods

We performed a preclinical investigation assessing the

effects of atomoxetine on the marble burying behavior test in mice.

The number of marbles buried in vehicle and atomoxetine treated

groupswasmeasured. Subsequently, we conducted a clinical inves-

tigation on five patients fulfilling the DSM-5 criteria for hoarding

disorder. These patients were treatedwith atomoxetine 40–100mg

for 12weeks. Full response was defined as a more of 35% decrease

in UCLA Hoarding Severity Scale (UHSS) and partial response was

defined as a more of 25% decrease in UHSS scale.

Results

Atomoxetine significantly reduced the number of buried

marbles in a dose dependent manner in comparison to control

mice, without affecting the locomotor activity. Three out of five

atomoxetine-treated patientswere classified as full responders and

two patients as partial responders after 12weeks of treatment.

Conclusions

These preclinical and clinical data suggest that ato-

moxetine may be considered as a potentially effective compound

for hoarding disorder and therefore should be considered for future

controlled trials in hoarding disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.476

EW359

Differential effects of coping

strategies on autogenous and reactive

obsessions

M.S. Lee

1 ,

, S.M. Kwon

2

1

Seoul National University Hospital, Department of Psychiatry,

Seoul, Korea

2

Seoul National University, Department of Psychology, Seoul, Korea

Corresponding author.

Introduction

Obsessive thoughts can be categorized into two sub-

types, autogenous obsessions and reactive obsessions. Although it

has been investigated that each subtype associates with different

maladaptive coping strategies, no studies have yet empirically com-

pared the effectiveness of adaptive coping strategies on autogenous

and reactive obsessions.

Objectives

It is hypothesized that acceptance, which is a core

therapeutic principle of acceptance-based cognitive therapy (ACT),

is more effective on autogenous obsessions, whereas response