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S242

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

EW368

The mediating role of metacogition in

the relation between intolerance of

uncertainty and obsessive-compulsive

disorder

S.Y. Sohn

1 ,

, I. Sohn

1

, S.Y. Lee

2

, S. Kim

1

1

Yonsei University College of Medicine, Department of Psychiatry and

Institute of Behavioral Science in Medicine, Seoul, Republic of Korea

2

Dankook University College of Medicine, Cheil General Hospital &

Women’s healthcare center, Psychiatry, Seoul, Republic of Korea

Corresponding author.

Introduction

Obsessive-compulsive disorder (OCD) is a severe

and incapacitating psychiatric disorder that is characterized by

recurrent intrusive thoughts (obsession). Maladaptive metacogni-

tion have been found to be associated with anxiety and various

psychopathology. Also, intolerance of uncertainty is considered to

be related with anxiety and ambivalence. These characteristics are

considered to be key characteristics of OCD.

Objectives

This study conceptualized metacognition as a medi-

ator in the relation between intolerance of uncertainty and

obsessive-compulsive symptom.

Aims

This studywas aimed to find prerequisites for development

of OCD.

Methods

The recruitment includes 150 OCD subjects and 50

healthy controls. Subjects were investigated with the metacog-

nition questionnaire (MCQ) and intolerance of uncertainty

questionnaire (IOU) as self-report measures. Participants with OCD

completed the Obsessive-Compulsive Inventory-Revised (OCI-R).

The OCI-R taps six OCD symptom dimensions: checking, hoarding,

neutralizing, obsessing, ordering and washing.

Results

OCD subjects showed significantly higher metacognition

score and significantly higher intolerance of uncertainty score than

control group. In OCD group, the results indicated that metacog-

nition partially mediated the relationship between intolerance of

uncertainty and obsessing.

Conclusions

Our findings suggest that metacognition may

explain the mechanism by which intolerance of uncertainty exerts

its effect on obsession.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.486

Oncology and psychiatry

EW369

Psychiatric comorbidities in patients

with brain tumors after

radiotherapy – An intermediate

report

M. Bran

1 ,

, M. Ladea

2

, D. Stanculescu

3

, T. Purnichi

3

1

Coltea Clinical Hospital, Bucharest, Romania

2

University of Medicine and Pharmacy “Carol Davila”, Psychiatry,

Bucharest, Romania

3

Clinical Hospital of Psychiatry “Prof. Dr. Al Obregia”, Psychiatry,

Bucharest, Romania

Corresponding author.

Introduction

Primary or secondary CNS tumors are among the

most difficult tomanage forms of cancer. Treatment of these tumors

remains a challenge in oncology and the success rates for treatment

of brain tumors are much lower than in extracerebral localiza-

tions. Because most chemotherapeutic agents do not cross the

blood-brain barrier effectively and surgery is sometimes only pal-

liative, radiotherapy remains the main method of treatment of

these lesions. Both localized and generalized brain radiotherapy

have numerous psychiatric complications.

Objectives

The objective of the studywas to assess the psychiatric

comorbidities inpatientswithbrain tumors receiving radiotherapy.

Aims

This is an intermediate report of a larger study that assesses

comorbidities in patients with brain tumors after radiotherapy.

Methods

Twenty-five patients with different localization brain

tumors were included in this observational study before receiv-

ing radiotherapy. All patients were assessed using Hospital Anxiety

and Depression Scale (HADS) for anxiety and depressive symptoms,

Montreal Cognitive Assessment (MOCA) for cognitive impairment

andQuality of Life Enjoyment and SatisfactionQuestionnaire–Short

Form (Q-LES-Q-SF) at inclusion and after 3months from finishing

the radiotherapy sessions.

Results

Twenty-two patients completed the study. Nine patients

received antidepressant treatment (sertraline, tianeptine) during

the study for depressive symptoms or anxiety. Patients receiving

antidepressants showed better scores on HADS, MOCA and Q-LES-

Q-SF scales.

Conclusions

Antidepressant use in patients receiving radiothe-

rapy for brain tumors could be neuroprotective and could improve

quality of life.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.487

EW370

Defence mechanisms and coping skills

in oncology patients

C. Bredicean

1 ,

, C. Giurgi-Oncu

1

, I. Papava

1

, R. Romosan

1

,

A. Jurma

1

, M. Cristanovici

2

, M. Hurmuz

3

, A. Popescu

3

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

2

South London and Maudsley NHS Foundation Trust, Mental Health

Learning Disabilities–Bethlem Royal Hospital Psychiatric, Mental

Health Learning Disabilities, London, United Kingdom

3

“Eduard Pamfil” Psychiatric Clinic Timisoara, Psychiatry, Timisoara,

Romania

Corresponding author.

Introduction

Oncology-related illnesses have become quite fre-

quent in our lives. Lately, medical progress in the field of oncology

has led to an increase in the survival rates of people diagnosed with

cancer. The minimisation of disturbances in the lives of these peo-

ple is done by each on their own, by using defence mechanisms and

coping skills.

Objectives

To identify the coping and defence mechanisms of

subjects diagnosed with cancer compared with non-clinical sub-

jects.

Aims

To increase quality of life of subjects diagnosed with cancer

through psychotherapy interventions.

Method

Nineteen subjects diagnosed with cancer who were

receiving chemotherapy were recruited to the study. For compari-

son, a control group of non-clinical participantswere also recruited.

Participants were included into the study according to particular

inclusion/exclusion criteria. The evaluation was conducted during

2014 and consisted of the analysis of the following parameters:

socio-demographic data, clinical data, defence mechanisms (DSQ-

60) and coping mechanisms (COPE scale).

Results

The group of subjects diagnosed with cancer demon-

strated the presence of defence mechanisms of the following

type: passive aggressiveness, projection and coping mechanisms

that were characterised by an emphasis on social support.

The control group had defence mechanisms of the following

types: repression, denial and coping mechanisms that focused on

emotions.