Table of Contents Table of Contents
Previous Page  238 / 812 Next Page
Information
Show Menu
Previous Page 238 / 812 Next Page
Page Background

S234

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

involved in the study. Cortical EEG sources were estimated by stan-

dardized low-resolution electromagnetic tomography (sLORETA)

in seven frequency bands: delta (1.5–6Hz), theta (6.5–8Hz), alpha-

1 (8.5–10Hz), alpha-2 (10.5–12Hz), beta-1 (12.5–18Hz), beta-2

(18.5–21Hz) and beta-3 (21.5–30Hz). Cognitive performance was

measured by the Trail-Making Test (version A and B). Emotional

states were induced by using two different scenarios. One of them

was autobiographical (related to OCD symptoms of the patient) and

the other aimed to induce general anxiety.

Results

Our results show different activation during exposure

autobiographical and generally anxiety scenario in patients with

OCD. During the exhibition, generally anxious scenario the activ-

ity changed in temporo-parietal areas both in OCD patients and

healthy controls. Whereas during the exposition to autobiograph-

ical scenario we found activity changes in frontal areas.

Conclusions

Our results suggest differences in the activation of

brain structures when exposed to specific and non-specific anxiety

in OCD patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.463

EW346

qEEG correlates of cognitive

impairment in obsessive compulsive

patients

D. Kamaradova

, J. Prasko , K. Latalova , A. Grambal , J. Taborsky ,

M. Hajda

University Hospital Olomouc, Psychiatry, Olomouc, Czech Republic

Corresponding author.

Introduction

Similar to patients with schizophrenia or bipolar

affective disorder many studies demonstrated presence of cogni-

tive impairment in OCD (obsessive-compulsive disorder) patients.

Aim of our study was to identify correlates of cognitive impairment

in OCD patients using quantitative EEG.

Methods

Resting-state eyes-closed EEG data were recorded in

twenty OCD patients and fifteen healthy controls that were

involved in the study. Cortical EEG sources were estimated by stan-

dardized low-resolution electromagnetic tomography (sLORETA)in

seven frequency bands: delta (1.5–6Hz), theta (6.5–8Hz), alpha-

1 (8.5–10Hz), alpha-2 (10.5–12Hz), beta-1 (12.5–18Hz), beta-2

(18.5–21Hz) and beta-3 (21.5–30Hz). Cognitive performance was

measured by the Trail-Making Test (version A and B).

Results

Frontal delta and theta EEG sources showed significantly

higher activity in the whole group of OCD patients (

n

= 20) than

in control subjects (

n

= 15). Subsequent analysis revealed that this

excess of low-frequency activity was present only in the subgroup

of 11 patients with cognitive impairment (based on the perfor-

mance in the Trail Making Test–A). The subgroup of patients with

normal cognitive functions (

n

= 9) did not differ in cortical EEG

sources from healthy controls.

Conclusion

The present results suggest that frontal low-

frequency cortical sources of resting state EEG rhythms can

distinguish groups of cognitively impaired and cognitively intact

OCD patients. Based on our results, future studies should consider

whether the present methodological approach provides clinically

useful information for the revelation of cognitive impairment in

OCD patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.464

EW347

The inattentive and hyperactive brain:

Significant links between corpus

callosum features and ADHD

symptoms in adulthood

E. Luders

1 ,

, F. Kurth

1

, D. Das

2

, D. Oyarce

2

, M. Shaw

2

,

P. Sachdev

3

, S. Easteal

4

, K. Anstey

2

, N. Cherbuin

2

1

UCLA School of Medicine, Neurology, Los Angeles, USA

2

Australian National University, Centre for Research on Ageing

Health and Wellbeing, Canberra, Australia

3

University of New South Wales, School of Psychiatry, Sydney,

Australia

4

Australian National University, John Curtin School of Medical

Research, Canberra, Australia

Corresponding author.

Introduction

Neuroimaging studies

of

attention-

deficit/hyperactivity disorder (ADHD) have revealed structural

deviations of the corpus callosum in children and adolescents.

However, little is known about the link between callosal morphol-

ogy and symptoms of inattention or hyperactivity in adulthood,

especially later in life.

Objective

We aimed to further expand this understudied field

by analyzing a large population-based sample of 280 adults (150

males, 130 females) in their late sixties and early seventies.

Methods

We applied a well-validated approach capturing the

thickness of the corpus callosum with a high regional specificity

at 100 equidistant points. In addition to correlating point-wise cal-

losal thickness with ADHD symptom measures within the whole

sample, we tested for sex interactions.

Results

There were significant sex interactions with respect to

measures of inattention and hyperactivity, with follow-up analyses

revealing significant negative correlations in males (see

Fig. 1

Top). In contrast, there were positive correlations with respect to

hyperactivity only in females (see

Fig. 1

Bottom).

Conclusion

A thinner corpus callosum may be associated with

fewer fibers or less myelination. Thus, the negative correlations, as

observed inmales, suggest an impaired inter-hemispheric commu-

nication necessary to sustain motor control and attention, which

may contribute to symptoms of hyperactivity, impulsivity and/or

inattention. The functional relevance and underlying mechanisms

of the positive correlations, as detected in females, remain to be

resolved.

Fig. 1