European Psychiatry - Volume 33 - March 2016

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S232 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Conclusions The majority of people who left the ATO zone have
emotional disorders of different severity and require a further cor-
rection in the specialized medical institutions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Neuroimaging
EW341
Intra-network and inter-network
shared connectivity patterns in
patients with remitted late-life
depression and amnestic mild
cognitive impairment
J. Chen ∗, H. Shu , Z. Wang , Y. Zhan , D. Liu , Y. Liu ,
Z. Zhang
1 Southeast University, Department of Neurology- Affiliated ZhongDa
Hospital, School of Medicine, Nanjing, China
2 Chinese Academy of Sciences, Brainnetome Center, Institute of
Automation, Beijing, China
∗ Corresponding author.
Objectives Both remitted late-life depression (rLLD) and amnestic
mild cognitive impairment (aMCI) alter brain function in individ-
ual regions. They are also disconnection syndromes associatedwith
a high-risk of developing Alzheimer’s disease (AD). Resting-state
functional connectivity magnetic resonance imaging (rs-fcMRI)
was performed to define the shared and distinct aberrant patterns
in intra-network and inter-network connectivity between rLLD and
aMCI.
Methods We investigated rs-fcMRI in five functionally well-
defined brain networks in 55 rLLD, 87 aMCI, and 114 healthy
controls (HC).
Results Compared with HC, rLLD showed a reduced degree of
functional connectivity in the bilateral inferior temporal cortex
and supplemental motor area, and reduced correlations within
the sensory-motor network (SMN) and in the default-mode net-
work (DMN) – control network (CON) pair. aMCI showed only
focal functional changes in regions of interest pairs, a trend toward
increased correlations within the salience network and SMN, and
a trend toward reduced correlation in the DMN-CON pair. Further-
more, rLLD exhibitedmore severely altered functional connectivity
compared to aMCI. Interestingly, these altered connectivities were
associated with specific multi-domain cognitive and behavioral
functions in both rLLD and aMCI. Notably, altered connectivity
between right middle temporal cortex and posterior cerebellum
was negatively correlatedwithMattis Dementia Rating Scale scores
in both rLLD and aMCI.
Conclusions These results demonstrate that rLLD and aMCI may
share convergent and divergent aberrant intra-network and inter-
network connectivity patterns. It further suggests that dysfunction
in right specific temporal-cerebellumneural circuit may contribute
to the similarities observed rLLD and aMCI conversion to AD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW342
Prefrontal cortical thickness related
to negative symptoms in
antipsychotic-naive, first-episode
psychotic patients
D. Guinart , D. Bergé , A. Mané , L. Galindo ∗,
O. Vilarroya , V. Perez-Sola
1 INAD, Institut de Neuropsiquiatria i Addiccions, Psychiatry,
Barcelona, Spain
2 Institut Municipal d’Investigacions Mèdiques IMIM, Psychiatry,
Barcelona, Spain
3 Universitat Autònoma de Barcelona UAB, Psychiatry, Barcelona,
Spain
4 Centro de Investigación Biomédica en Red de Salud Mental
CIBERSAM, G21, Psychiatry, Barcelona, Spain
∗ Corresponding author.
Introduction A significant cortical thinning has been repeatedly
observed in adult-onset first-episode schizophrenia patients com-
pared to healthy controls, mostly in medial and inferior prefrontal
cortices. However, it is yet unclear whether all these replicated
alterations are related to any particular clinical feature.
Objectives This study aimed to investigate differences of corti-
cal thickness in a sample of first-episode, drug-naive psychotic
patients and age- and gender-matched healthy controls and
explore clinical correlates of these parameters regarding negative
symptoms.
Methods High-resolution T1-weighted images were acquired
from 23 antipsychotic-naive, first-episode psychotic patients and
26 age-matched healthy comparison subjects. Clinical features
were measured with the negative subscale of the Positive and Neg-
ative Syndrome Scale (PANSS) at baseline and after a 2-month
follow-up period.
Results No differences were found regarding age or gender when
comparing patients and controls. We found a significant cortical
thinning in the left medial orbitofrontal cortex and in the right lat-
eral orbitofrontal cortex in patients compared to healthy age- and
gender-matched controls. Regarding clinical performance, no cor-
relation was found at baseline between left medial orbitofrontal
nor right lateral ortitofrontal cortical thickness and scores of the
negative subscale of the PANSS. However, at the 2-month evalua-
tion clinical performances were significantly associated to the left
medial orbitofrontal cortical thickness values.
Conclusions Cortical thickness alterations in prefontal cortex
appear to be present at disease onset and these alterations may
relate to clinical outcome. However, our findings must be con-
sidered just as exploratory. Larger longitudinal studies may help
characterize, replicate and consolidate these findings.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW343
A functional neuroimaging
investigation of brain pathways
involved in patients during active
mania using Stroop Colour Word Test
R. Gupta ∗, P. Goyal , R. Ranjan , S. Kumaran , R. Sagar
1 All India Institute of Medical Sciences, Psychiatry, New Delhi, India
2 All India Institute of Medical Sciences, Nuclear Magnetic Resonance,
New Delhi, India
∗ Corresponding author.
Introduction Cognitive deficits are characteristic features of
mania but their underlying pathways are not well defined.
Aims and objectives The present study was conducted to explore
the various brain regions implicated in response inhibition in active
mania.