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S232

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Conclusions

The majority of people who left the ATO zone have

emotional disorders of different severity and require a further cor-

rection in the specialized medical institutions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.458

Neuroimaging

EW341

Intra-network and inter-network

shared connectivity patterns in

patients with remitted late-life

depression and amnestic mild

cognitive impairment

J. Chen

1 ,

, H. Shu

1

, Z. Wang

1

, Y. Zhan

2

, D. Liu

1

, Y. Liu

2

,

Z. Zhang

1

1

Southeast University, Department of Neurology- Affiliated ZhongDa

Hospital, School of Medicine, Nanjing, China

2

Chinese Academy of Sciences, Brainnetome Center, Institute of

Automation, Beijing, China

Corresponding author.

Objectives

Both remitted late-life depression (rLLD) and amnestic

mild cognitive impairment (aMCI) alter brain function in individ-

ual regions. They are also disconnection syndromes associatedwith

a high-risk of developing Alzheimer’s disease (AD). Resting-state

functional connectivity magnetic resonance imaging (rs-fcMRI)

was performed to define the shared and distinct aberrant patterns

in intra-network and inter-network connectivity between rLLD and

aMCI.

Methods

We investigated rs-fcMRI in five functionally well-

defined brain networks in 55 rLLD, 87 aMCI, and 114 healthy

controls (HC).

Results

Compared with HC, rLLD showed a reduced degree of

functional connectivity in the bilateral inferior temporal cortex

and supplemental motor area, and reduced correlations within

the sensory-motor network (SMN) and in the default-mode net-

work (DMN) – control network (CON) pair. aMCI showed only

focal functional changes in regions of interest pairs, a trend toward

increased correlations within the salience network and SMN, and

a trend toward reduced correlation in the DMN-CON pair. Further-

more, rLLD exhibitedmore severely altered functional connectivity

compared to aMCI. Interestingly, these altered connectivities were

associated with specific multi-domain cognitive and behavioral

functions in both rLLD and aMCI. Notably, altered connectivity

between right middle temporal cortex and posterior cerebellum

was negatively correlatedwithMattis Dementia Rating Scale scores

in both rLLD and aMCI.

Conclusions

These results demonstrate that rLLD and aMCI may

share convergent and divergent aberrant intra-network and inter-

network connectivity patterns. It further suggests that dysfunction

in right specific temporal-cerebellumneural circuit may contribute

to the similarities observed rLLD and aMCI conversion to AD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.459

EW342

Prefrontal cortical thickness related

to negative symptoms in

antipsychotic-naive, first-episode

psychotic patients

D. Guinart

1 , 2

, D. Bergé

1 , 2 , 3 , 4

, A. Mané

1 , 2 , 3 , 4

, L. Galindo

1 , 2 , 3 ,

,

O. Vilarroya

2 , 3

, V. Perez-Sola

1 , 2 , 3 , 4

1

INAD, Institut de Neuropsiquiatria i Addiccions, Psychiatry,

Barcelona, Spain

2

Institut Municipal d’Investigacions Mèdiques IMIM, Psychiatry,

Barcelona, Spain

3

Universitat Autònoma de Barcelona UAB, Psychiatry, Barcelona,

Spain

4

Centro de Investigación Biomédica en Red de Salud Mental

CIBERSAM, G21, Psychiatry, Barcelona, Spain

Corresponding author.

Introduction

A significant cortical thinning has been repeatedly

observed in adult-onset first-episode schizophrenia patients com-

pared to healthy controls, mostly in medial and inferior prefrontal

cortices. However, it is yet unclear whether all these replicated

alterations are related to any particular clinical feature.

Objectives

This study aimed to investigate differences of corti-

cal thickness in a sample of first-episode, drug-naive psychotic

patients and age- and gender-matched healthy controls and

explore clinical correlates of these parameters regarding negative

symptoms.

Methods

High-resolution T1-weighted images were acquired

from 23 antipsychotic-naive, first-episode psychotic patients and

26 age-matched healthy comparison subjects. Clinical features

were measured with the negative subscale of the Positive and Neg-

ative Syndrome Scale (PANSS) at baseline and after a 2-month

follow-up period.

Results

No differences were found regarding age or gender when

comparing patients and controls. We found a significant cortical

thinning in the left medial orbitofrontal cortex and in the right lat-

eral orbitofrontal cortex in patients compared to healthy age- and

gender-matched controls. Regarding clinical performance, no cor-

relation was found at baseline between left medial orbitofrontal

nor right lateral ortitofrontal cortical thickness and scores of the

negative subscale of the PANSS. However, at the 2-month evalua-

tion clinical performances were significantly associated to the left

medial orbitofrontal cortical thickness values.

Conclusions

Cortical thickness alterations in prefontal cortex

appear to be present at disease onset and these alterations may

relate to clinical outcome. However, our findings must be con-

sidered just as exploratory. Larger longitudinal studies may help

characterize, replicate and consolidate these findings.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.460

EW343

A functional neuroimaging

investigation of brain pathways

involved in patients during active

mania using Stroop Colour Word Test

R. Gupta

1 ,

, P. Goyal

1

, R. Ranjan

1

, S. Kumaran

2

, R. Sagar

1

1

All India Institute of Medical Sciences, Psychiatry, New Delhi, India

2

All India Institute of Medical Sciences, Nuclear Magnetic Resonance,

New Delhi, India

Corresponding author.

Introduction

Cognitive deficits are characteristic features of

mania but their underlying pathways are not well defined.

Aims and objectives

The present study was conducted to explore

the various brain regions implicated in response inhibition in active

mania.