European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S511
Aims The aim of the present study was to investigate the preva-
lence of major depression across a sample of Iranian community
pharmacists.
Methods One hundred and eighty surveys were distributed
among community pharmacists attending different continuous
medical education programs from all over the country during
winter 2015. Beck Depression Inventory was used to measure
characteristic attitudes and symptoms of depression. Descriptive
statistics were utilized to find prevalence of mild, moderate or
severe depression among the study sample. Independent sample t-
testswere used to find possible differences between age and gender
of the respondents and prevalence of depression.
Results Survey response rate was calculated to be 84.7%. Accord-
ing to the results, 72.7% of the respondents were categorized to be
normal, whereas 12.8% were found to have mild, 11.7% moderate,
and 2.8% severe depression. Moreover, no significant relation-
ship was found between age of the respondent and prevalence
of depression (P > 0.05). However, the prevalence was found to be
higher among females (P < 0.001).
Conclusions Prevalence of depression among community phar-
macists was reported to be low. However, it may affect healthcare
services that they provide in the healthcare system. Further studies
with larger sample size are suggested.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV507
Depression and its correlation with
the risk of cardiovascular mortality in
primary care population in Latvia
R. Ivanovs ∗, M. Trapencieris , J. Vrublevska , R. Logins ,
L. Berze , E. Rancans
1 Riga, Latvia
2 University of Latvia, Institute of Philosophy and Sociology, Riga,
Latvia
3 Riga Stradins University, Department of Psychiatry and Narcology,
Riga, Latvia
4 Riga Stradins University, Department of Continuing Education, Riga,
Latvia
∗ Corresponding author.
Introduction Depression is one of several preventable causes of
disability worldwide, with coronary heart disease (CHD) being the
largest cause of disability. Depression has been confirmed as a risk
factor for CHD.
Objectives Few studies tried to find an interrelation between
depression and a risk of cardiovascular mortality according to sys-
tematic coronary risk evaluation (SCORE) chart.
Aims The aim of study was to examine the correlation of depres-
sion with the risk of cardiovascular mortality (SCORE).
Methods Study was conducted in 2015 within the framework of
National Research Programme BIOMEDICINE. All patients aged 18
and older at 24 primary care facilities were interviewed with a
sociodemographic questionnaire supplemented by measurements
of blood pressure and total cholesterol. Within 2 weeks after the
visit psychiatrist administered the Mini International Neuropsy-
chiatric Interview (MINI) by telephone. SCORE was assessed using
high risk chart.
Results Totally 920 patients age 40–69 were included in the data
analysis. According to the MINI 9.3%(95%CI 7.5–11.5%) of 40–69
years old patients had current depression. Current depression was
more common among women than men, 10.4% and 6.8%, respec-
tively. The prevalence of current depression was highest among
patients with SCORE 3–4%. Multivariate logistic regression did not
suggest statistically significant odds ratio for having depression
based on SCORE.
Conclusions Only one of the measurements used for SCORE
(smoking status) was significant predictor for having current
depression, while systolic blood pressure and total cholesterol were
not significant predictors for depression. As pharmacotherapies
for reducing blood pressure and cholesterol are widely used by
patients further research should include use of these medicines as
potential mediators.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV508
Energy drinks changed the treatment
of antidepressant drugs
C¸ . Macit , B. Kadıo˘glu , G. Dalan , M. Maassarani , E. Yönel ,
T. C¸ elik ∗
1 Yeditepe University, School of Pharmacy-Department of
Pharmacology, Istanbul, Turkey
2 Yeditepe University, School of Pharmacy, Istanbul, Turkey
3 Yeditepe University, School of Pharmacy- Department of Clinical
Pharmacy, Istanbul, Turkey
∗ Corresponding author.
Introduction The increasing use of antidepressants (ADS)
whether it is for the management of depression or off-label use
is apparent and it is important to have a closer look on the possi-
ble effects that accompany the use of ADS with other neurotonic
agents, such as the ones found in energy drinks(ED). ED pose a
threat on public health since they can be consumed by everyone
with no limitations.
Aims We investigated the unknown interaction that might occur
when ADS are used in combination with ED.
Methods The effect of both low (4 mL/kg) and high (12 mL/kg)
EDdoses onmice treatedwith an ADS (citalopram15mg/kg, IP) and
non-treated were investigated after acute exposure and 14 days of
chronic exposure. The changes that resulted from performing the
Locomotor Activity test (LMA) and the Porsolt’s Forced Swim test
(FST) were recorded.
Results The administration of both low and high energy drink
dose resulted in significant impairments in LMA of mice. High dose
ED showed a significant increase in the immobility time in FST.
Mice treated with citalopram resulted in a decrease in the immo-
bility timewhen compared tomice administered only saline and/or
to mice exposed to ED. However, for the mice that were exposed
to both low and high dose ED, citalopram administration did not
significantly decrease their immobility time.
Conclusion High dose energy drink caused an increase in the
immobility time in FST. Concomitant use of citalopram and ED
decreased the antidepressant effect of citalopram. Thereby patients
using ED with ADS may encounter insufficient drug therapy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV509
Dermatological manifestations in
pregnancy with primary psychiatric
findings
A. Wahab ∗ Kalar assan Alzaabi ira Bibi
A. Jamal , M.U. Kalar , G. Wahab , T. Usman , M.O. Suriya ,
E. Mujeeb
1 Karachi Medical and Dental College- Abbasi Shaheed Hospital,
Department of Gynecology and Obstetrics, Karachi, Pakistan
2 Department of Obstetrics and Gynecology, Singleton Hospital, South
Wales, Sketty Swansea, UK
3 Department of Medicine, Department of Medicine, Karachi Karachi
Medical & Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan