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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S509

(2014) showed that sunshine induces different responses in female

than male mice in preclinical models of depression.

Objective

To determine whetehr the sunshine induced placebo

effect exhibits gender differences in human.

Materiel and methods

Data from 9 double-blind, randomized,

placebo-controlled studies of antidepressants conducted by the

French GICIPI network were reviewed. MADRS (5) or HAM-D 17

(4) were used as the main efficacy tool. For each patient, variation

of scores (Delta MADRS/Delta HAM-D) between two consecutive

visits were correlated with the average sunshine index observed

at noon between these visits. Sunshine indexes were provided by

Météo-France. Correlations were computed with Microsoft Excel.

Results

Analysis of both genders (

n

= 52) showed no statisti-

cally significant (NS) correlation (

r

2

= 0.0064) between sunshine

and score variations. Analysis of males (n = 8) failed to demon-

strate any significant correlation in cloudy (< 1000 Joules/cm

2

),

variable (1000–2000 Joules/cm

2

) or sunny (> 2000 Joules/cm

2

)

weather. Analysis of females (

n

= 44) showed NS correlation as well

for cloudy or variable weather (

r

2

= 0.0016), but a strong correla-

tion was observed for females exposed to sunny weather:

r

2

= 0,

315,

n

= 20,

P

< 0.01. This correlation was even stronger in the sub-

population of females aged less than 50 years:

r

2

= 0.6398,

n

= 12,

P

< 0.001.

Discussion

The hypothesis underlying this correlation between

sunshine index and variations of MADRS/HAMD scales will be dis-

cussed.

Conclusion

Sunshine increases placebo effect in female patients

aged less than 50. This insufficiently known effect may be respon-

sible for failure of a number of double-blind, randomized, studies

of antidepressant compounds.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1485

EV501

Depressive symptomatology and

learning: Does intermediate testing or

restudying the information determine

long-term memory retrieval of novel

symbols?

V. Giannouli

Aristotle University of Thessaloniki, School of Medicine, Thessaloniki,

Greece

Introduction

There is a hypothesis in cognitive psychology that

long-term memory retrieval is improved by intermediate testing

than by restudying the information. The effect of testing has been

investigated with the use of a variety of stimuli. However, almost

all testing effect studies to date have used purely verbal materials

such as word pairs, facts and prose passages.

Objective

Here byzantinemusic symbol–word pairs were used as

to-be-learned materials to demonstrate the generalisability of the

testing effect to symbol learning in participants with and without

depressive symptoms.

Method

Fifty healthy (24 women, M age = 26.20, SD = 5.64) and

forty volunteerswith high depressive symptomatology (20women,

M age = 27.00, SD = 1.04) were examined. The participants did not

have a music education. The examination material was completely

new for them: 16 byzantine music notation stimuli, paired with a

verbal label (the ancient Greek name of the symbol). Half of the par-

ticipants underwent intermediate testing and the others restudied

the information in a balanced design.

Results

Results indicated that there were no statistically signifi-

cant differences in final memory test performance after a retention

interval of 5minutes for both groups of participants with low and

high level depressive symptomatology (

P

> 0.005). After a retention

interval of aweek, tested pairswere retained better than repeatedly

studied pairs for high and low depressive symptomatology groups

(

P

< 0.005).

Conclusions

This research suggests that the effect of testing time

on later memory retrieval can also be obtained in byzantine symbol

learning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1486

EV502

Anhedonia, anxiety, and depression

components of Edinburgh postnatal

depression scale in cesarean delivery

L. Giliberti

, F. Volpe , G. Soldera , G. Tesolat , R. Maione ,

G. Straface , V. Zanardo

Policlinico Abano Terme, Division of Perinatal Medicine, Abano

Terme, Italy

Corresponding author.

Introduction

Previous studies have indicated that cesarean deliv-

ery might pose risk factors for post-partum depression (PPD).

However, results are conflicting and have failed to clearly distin-

guish between elective (ElCD) and emergency (EmCD) cesarean

delivery.

Objective

The rate of elective cesarean delivery is rapidly increas-

ing all over the world and it is important to identify whether the

mode of delivery has an influence on PPD. The Edinburgh Postna-

tal Depression Scale (EPDS) is a widely used instrument for PPD

screening, also capable to detect in subscales anhedonia, anxiety,

and depression factors.

Methods

A cohort of 959 Italian mothers delivering a healthy

baby at Policlinico Abano Terme, Italy, completed the EPDS 2 days

after delivery.

Results

EPDS scores were significantly higher in mothers with

a cesarean delivery compared to mothers with a vaginal delivery

(7.0

±

4.8 vs 6.1

±

4.2,

P

< 0.01), but only the women who elected to

have a caesarean section had significantly higher scores (7.1

±

3.9

vs. 6.8

±

4.1,

P

< 0.001). Additionally, the factor analysis of EPDS

indicated that anhedonia, anxiety, and depression were signifi-

cantly higher in women who elected to have a caesarean section.

Conclusions

The results of our study indicate that women who

had an ElCD have an increased risk of developing early symptoms

of post-partum depression, anxiety, and anhedonia. In particular,

this study shows that the use of EPDS subscales in the immediate

post-partum is a good tool to better understanding the spectrum of

maternal post-partum psychological problems related to delivery

mode.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1487

EV503

Chronotherapy for depression: A

useful adjunctive therapy?

J. Gomes

, A. S

ousa , H. Afonso , G. Lima

Centro Hospitalar Barreiro-Montijo, Psychiatry, Barreiro, Portugal

Corresponding author.

Introduction

Since ancient times the influence of chronobiologi-

cal factors on the pathogenesis, course, and treatment of depression

has been well known. Chronotherapy is the controlled exposure to

environmental stimuli that act on biological rhythms in order to

achieve therapeutic effects in the treatment of psychiatric condi-

tions. It includes sleep deprivation, bright light therapy and sleep

phase advance.