European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S515
Aim . The program was addressed to three groups of patients
with burnout, infertility, and social relationship/loneliness crisis.
Method Using the new stress reduction program (SRP), engag-
ing both pharmacological and psychotherapeutic approach, and
also several lifestyle factors, like physiotherapy, nutrition aspects,
coaching, social media contact and monitoring, most of patients
improved in terms of emotional and behavioral markers, in short-
and long-term (4–6 months) observations.
Material Patients and clients (N43) with F3.x-F4.x disorders
according to ICD-10.
Results A variety of PRS scales were used to assess patients’
improvement outcomes. Significant reductions (4–6 months) were
observed at Maslach Burnout Inventory (–23.4%, P = 0.000), Fertility
Problem Inventory (–34.5%, P = 0.000), UCLA Loneliness Scale, ver.
3 (–43.3%, P = 0.000), and Perceived Stress Scale (44.0%, P = 0.000).
Discussion This program interplays between stress and mental
health problems and opens up new possibilities for diagnosis and
therapy, focusing on the challenges of civilization, and especially
opens up preventive options in stress-related problems and dis-
eases, which represent a growing health burdens inmodern society.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV519
Metabolic dysregulation as predictor
for the course of late-life depression
R. Marijnissen ∗, N. Vogelzangs , M. Mulder , R. van den Brink ,
H. Comijs , R. Oude Voshaar
1 Wolfheze, Netherlands
2 VU University Medical Center, Department of
Psychiatry/GGZinGeest & Institute for Extramural Medical Research
EMGO, Amsterdam, Netherlands
3 Arnhem, Netherlands
4 University Medical Center Groningen- University of Groningen,
University Center of Psychiatry & Interdisciplinary Center for
Psychopathology of Emotion Regulation, Groningen, Netherlands
∗ Corresponding author.
Introduction Depression is associated with the metabolic syn-
drome (MS). Recently, the concept of ‘metabolic depression’ has
been proposed based on a protracted course of depressive symp-
toms over time.
Objective and aims Within the Netherlands study of depression
in older persons, we examined whether metabolic dysregulation
predicted the two-year course of depression.
Methods A cohort study (n = 285) of depressed persons (≥60
years) with two-year follow up. Depression was classified accord-
ing to the Diagnostic and Statistical Manual of Mental Disorders,
Fourth Edition (DSM-IV). Severity of depression was assessed with
sum score as well as subscale scores of the Inventory of Depres-
sive Symptomatology (IDS) at six-month intervals. The metabolic
syndrome was defined according the National Cholesterol Educa-
tion Program (NCEP-ATP III). We applied logistic regression and
linear mixed models adjusted for a wide range of confounders and
severity of depression at baseline.
Results The number of MS-components predicted non-remission
at two-years (OR = 1.28 [95% CI: 1.00–1.58], P = 0.047), which
was driven by waist-circumference, HDL-cholesterol and triglyc-
erides. MS was only associated with the somatic symptom
subscale score of the IDS over time, but not with its sum score
(interaction time ×somatic subscale, P = 0.002). This effect was
driven by waist circumference, elevated fasting glucose level and
hypertension.
Conclusion Metabolic dysregulation predicts the course of late-
life depression. This effect seems to be driven by visceral obesity
(as indicated by the waist circumference) and lipid dysregulations
and with respect to the somatic symptoms of depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV520
The role of self-compassion in lifetime
history of depression: A study in
Portuguese pregnant women
E. Bento avier zevedo Marques . Soares
M.J. Martins ∗, P. Castilho , N. Madeira , A. Macedo ,
A.T. Pereira
1 Faculty of Medicine-University of Coimbra, Department of
Psychological Medicine, Coimbra, Portugal
2 Coimbra Hospital and University Centre-Portugal, Psychiatry,
Coimbra, Portugal
3 Faculty of Psychology and Educational Sciences - University of
Coimbra, CINEICC, Coimbra, Portugal
∗ Corresponding author.
Introduction Although self-compassion has been pointed as an
effective strategy for coping with depression, there are not any
studies investigating its associationwith lifetime history of depres-
sion (LTHD).
Objective To compare self-compassion levels in pregnant women
with vs. without LTHD and to analyze if self-compassion dimen-
sions are significant predictors of LTHD.
Methods Four hundred and twenty-seven pregnant women with
a mean age of 33 years (±4.785) in their second trimester of preg-
nancy completed the Self Compassion Scale validated for pregnancy
(SCS; Bento et al., 2015) and a new self-report questionnaire to
evaluate the presence of LTHD according to DSM-5 criteria for
depression.
Results Ninety-seven (23.0%) women had LTHD. Bisserial Spear-
men correlations between LTHD and SCS total score were
significant, negative and moderate (r = –0.31). SCS subscales,
except Common Humanity, showed significant correlations:
Self-Kindness/SK (r = –0.130), self-judgement (SJ) (0.313), iso-
lation (0.357), mindfulness ( r= –0.102), over-identification (OI)
(r= 0.393). Independent sample t tests revealed that women with
vs. without LTHD had significantly lower levels of total SCS, SK and
Mindfulness scores and higher levels of SJ, Isolation and OI.Logistic
regression (assumptions were fulfilled, Tabachnick and Fidell,
2007) showed that the SCS explained 26.7%–43.6% of the LTHD vari-
ance and correctly classified 86.9%; the odds ratio (OR) was.865
(95% CI 0.834–0.898; P < 0.001). The model composed by the cor-
related dimensions explained 15.9%–24.0% and correctly classified
80.6%. Odds ratios: SK = 0.017; SJ = 0.021; isolation = 16.027; mind-
fulness = 0.167 and OI = 20.178 (all P < 0.05).
Conclusions Self-compassion, specifically the ability to treat one-
self with care and understanding and to be aware and accepting
one’s present-moment experiences, decrease the probability of
having LTHD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV521
Interictal depressive disorders in
epilepsy patients
A. Matos Pires ∗, Y. Martins , M. Suarez Gomez
Local Health Unit of Baixo Alentejo, Department of Psychiatry and
Mental Health, Beja, Portugal
∗ Corresponding author.
Introduction Depression is recognized as more frequent psychi-
atric disorder in epilepsy patients with significant impact on their
health-related quality of life.