European Psychiatry - Volume 33 - March 2016

525 / 812

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S521
2 “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 3th
Department, Bucuresti, Romania
3 “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 4th
Department, Bucuresti, Romania
4 “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, “Prof.
Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, Bucuresti,
Romania
∗ Corresponding author.
Introduction The quality of life in patients with depression may
be a measure of the efficiency of its management. Although quality
of life is a subjective concept, difficult to assess, it may be reflected
by the degree of social adaptation and the individual’s level of func-
tioning.
Objective The study evaluates the time evolution of depressive
symptoms and of some parameters attesting the quality of life
in patients diagnosed with depression who are on antidepressant
treatment.
Aims Highlighting the evolution in time of depressive symp-
toms and patients’ perceptions on some aspects of quality of
life.
Methods There were included 23 patients who met the criteria of
depressive episode, single or within recurrent depressive disorder,
according to the International Classification of Diseases (ICD-10-
AM), requiring antidepressant treatment. Subjects were evaluated
at baseline and after 12 weeks of treatment using the Hamilton
Rating Scale for Depression (HAMD), Sheehan disability scale (SDS),
Social Adjustment Scale – Self-report (SASS).
Results Statistically significant decrease in mean HAMD scores
was observed in the second administration. There were registered
statistically significant differences of scores obtained in the two
administrations for the 17 items of the SASS scale. Correlationswith
statistical significance between HAMD scores and some of the SDS
areas were observed.
Conclusions Results showed a favorable course of depressive
symptoms while under treatment and differences in time of sub-
jects’ perception on several aspects evaluated on SASS for the group
studied. Correlations with statistical significance between HAMD
scores and some SDS areas were observed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV537
A comparison of the improving in
major depressive symptoms as
reported by Romanian physicians and
patients in a prospective, multicenter,
observational study
T. Purnichi ∗ arinescu Ladea . Eda
I. Marinescu Pirlog avel Mihalcea Paraschiv
C. Tudose
1 Alexadru Obregia Psychiatric Hospital, Psychiatry, Bucharest,
Romania
2 Constanta Psychiatric Hospital, Psychiatry, Constanta, Romania
3 Craiova Psychiatric Hospital, Psychiatry, Craiova, Romania
∗ Corresponding author.
Introduction Depression leads to substantial suffering for the
patients, their families and becomes an economic burden for
system [1,2]. Patients and clinicians tend to rate the remission dif-
ferently [3].
Objectives and methods We investigate if clinicians and patients
rate different the treatment response. This study assed the evolu-
tion of major depressive episode (MDE) in patients treated with
Agomelatine, in Romania. It was designed as a multicentre, obser-
vational study that included 1213 adult patients evaluated in 75
sites in 2014. The design included 3 visits (baseline (V1); visit at 2/3
weeks (V2); visit 6/8 weeks (V3)). The scales used were: MADRS,
SHAPS, CGI-I, CGI-S, PGI-I, PGI-S.
Results The MDE improvement was significant (P < 0.001) for all
aspects evaluated. At baseline, more clinicians vs. patients consid-
ered the moderately or markedly ill as best descriptors of the state.
The difference between the two assessments was even higher for
V2 and V3. During V2 clinicians reported “minimally improvement”
while patients reported “much improvement” in higher percent-
age. During V3, both, clinicians and patients reported a “very much
improved” clinical status. Of the patients 42.60% reported at V3
“normal”, not at all ill’ in comparison to 34.81% of clinicians who
reported the same (P < 0.001).
Conclusions This could mean that patients are not aware of the
severity of their disease. This data could be interpreted in the way
that patients are more prone to rate higher the improvements as
response to treatment and the clinicians to rate as response a more
than 50% decrease of symptomatology.
References not available.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV538
Rumination and primary care
depression
K. Riihimäki ∗, M. Vuorilehto , P. Jylhä , E. Isometsä
1 Health Care and Social Services, MPY, Järvenpää, Finland
2 University of Helsinki and Helsinki University Hospital, Department
of Psychiatry, Helsinki, Finland
∗ Corresponding author.
Introduction Response styles theory postulates that rumination
is a central factor in occurrence, severity and maintaining of
depression. High neuroticism has been associated with tendency
to ruminate.
Objective To evaluate the relationships between rumination,
neuroticism and depression in a naturalistic prospective cohort
of primary care patients with depressive disorders with life-chart
methodology.
Aims We hypothesized, that rumination would correlate with
severity and duration of depression and with concurrent anxiety,
gender and neuroticism.
Methods In the Vantaa Primary Care Depression Study, a strat-
ified random sample of 1119 adult patients was screened for
depression using the Prime-MD. Depressive and comorbid psychi-
atric disorders were diagnosed using SCID-I/P and SCID-II. Of the
137 patients with depressive disorders, 82% completed the five-
year follow-upwith a graphic life chart. Neuroticismwas measured
with the Eysenck Personality Inventory (EPI-Q). Response styles
were investigated at five years using the Response Styles Ques-
tionnaire (RSQ-43).
Results Rumination correlated significantly with Hamilton
Depression Rating Scale (r= 0.54), Beck Depression Inventory
(r= 0.61), BeckAnxiety Inventory ( r = 0.50), BeckHopelessness Scale
(r= 0.51) and Neuroticism ( r= 0.58). Rumination correlated also
with proportion of follow-up time spent depressed (r = 0.38). In
multivariate regression, high rumination was significantly pre-
dicted by current depressive symptoms and neuroticism, but not
by anxiety symptoms or preceding duration of depressive episodes.
Conclusions Rumination correlated with current severity of
depression, but the association with preceding episode duration
remained uncertain. The association between neuroticism and
ruminationwas strong. The findings are consistentwith rumination
as a state-related phenomenon, which is also strongly intertwined
with traits predisposing to depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.