European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S517
Methods The sample is based on the large Northern Finland Birth
Cohort 1966. Temperament traits were measured at age 31 years
using the Temperament and Character Inventory. At the age of
46 years depressive symptoms were measured using the Beck
Depression Inventory – II (BDI). The sample included those with
self-reported life-time depression history at age 46 years but not
yet at age 31 years (n = 298). Temperament at age 31 years was used
to predict remission (BDI≤13) at age 46 years using logistic regres-
sion analysis, with gender and educational level as confounders.
Cohen’s d was used as effect size measure.
Results Two hundred and one (67.4%) of individuals with self-
reported depression were on remission at the follow-up. Low
harm avoidance (total scale, and subscales anticipatory worry, shy-
ness, and fatigability), low impulsiveness and high exploratory
excitability (subscales of novelty seeking), and low sentimentality
(subscale of reward dependence) predicted significantly remission
with effect sizes between 0.28 and 0.45, highest effect being inharm
avoidance.
Conclusions Different temperament traits were able to predict
remission status in depression. Effect sizes were between small and
moderate. Temperament may associatewith treatment response in
depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV525
The importance of art therapy in the
integrative treatment of recurrent
depressive disorder – case study
J. Pavlovic Stojkovic , M. Milosavljevic ∗, M. Vukovic , L. Vidic ,
D. Lecic Tosevski
1 Institute of Mental Health, Clinical Department for Crisis Situations
and Affective Disorders, Belgrade, Serbia
2 Serbian Academy of Sciences and Arts, Medicine, Belgrade, Serbia
3 University of Belgrade, Medical Faculty, Belgrade, Serbia
∗ Corresponding author.
An integrative treatment of patients with affective disorders dur-
ing hospitalisation also includes art therapy. Art therapy, as a form
of expressive therapy, uses the creative process to encourage com-
munication, expression of feelings and offers the space for mutual
mirroring. This paper presents a patient who has been treated
for approximately five years under the diagnosis of a recurrent
depressive disorder (F33) and mixed personality disorder (F61).
The patient has been experiencing unrecognised and untreated
problems of the depression spectrum since 1993, when he took
part in the Yugoslav war. The main issue was the somatic symp-
toms (headaches, nausea etc). Another major problem during his
psychiatric treatment and an additional cause of unsatisfactory
therapeutic effect was his inability to verbalise his feelings. In the
course of art therapy, when the patient was given a topic “How I see
myself in five years”, he drew a man who appeared to be sleeping
and explained that he could not see himself in five years’ time, since
he would not be alive at the time and that he could not see a way
out of the current situation. With the help of a supportive group, for
the first time since the beginning of his treatment, he spoke about
his thoughts and feelings of hopelessness, sorrow, alienation and
loneliness. This enabled new insight into the patient’s depression.
This clinical example shows how art therapy and reaction of the
group, which was supportive and highly associative, can turn the
non-verbal into verbal and non-communication into communica-
tion.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV526
Toward evidence-based medical
statistics: Re-evaluate the efficacy of
antidepressants by using Bayes factors
R. Monden ∗, D.V. Stijn , W. Klaas , R. Annelieke , M. Richard ,
W. Eric-Jan
1 University Medical Center Groningen, Psychiatry, Groningen,
Netherlands
2 Cardiff University, School of Psychology, Cardiff, United Kingdom
3 University of Amsterdam, Psychology, Amsterdam, Netherlands
∗ Corresponding author.
Introduction Studies have been reported the similar efficacy of
antidepressants (effect size around 0.3), and it is difficult for clin-
icians to select an antidepressant. This may partly due to the use
of a p<.05 null-hypothesis significance testing (NHST) framework
to evaluate “substantial evidence”. This framework only allows
dichotomous conclusions and does not quantify the strength of
evidence supporting efficacy. In addition, meta-analyses based on
publications may offer positively biased results due to selective
publications.
Objectives Demonstrate that the Bayesian framework can pro-
vide valuable information on the strength of the evidence for drug
efficacy.
Aims Re-evaluate the efficacy of FDA-approved antidepressants
applied to anxiety disorders and depression by means of Bayes
factors.
Methods To avoid selective publication, data of double-blind
placebo-controlled trials for FDA-approved antidepressants for the
treatment of anxiety disorders and depressionwere extracted from
the FDA. Bayes factors (BFs) were calculated and comparedwith the
results obtained under NHST framework.
Results A large variance of evidence for the efficacy of antide-
pressants was found for both depression and anxiety disorders.
Among trials providing “substantial evidence” according to the
FDA for anxiety disorders, only 27 out of 59 dose groups obtained
strong support for efficacy according to the typically used cut-off
of BF≥ 20. For depression, all FDA-approved antidepressants had
BF≥20, except for bupriopion. Moreover, it was shown that the
tested antidepressants can be differentiated based on the strength
of evidence and effect size.
Conclusions The BFs quantified the comparative evidence base
for the efficacy of antidepressants.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV527
Anxiety, depression, perceived social
support and quality of life in
Malaysian breast cancer patients: A
1-year prospective study
C.G. Ng ∗, S. Mohamed , M.H. See , F. Harun , A.H. Sulaiman ,
N.Z. Zainal , N.A. Taib
1 University of Malaya, Department of Psychological Medicine, Kuala
Lumpur, Malaysia
2 Faculty of Medicine-Universiti Teknologi MARA, Department of
Psychiatry, Kuala Lumpur, Malaysia
3 University Malaya Medical Centre, Department of Surgery, Kuala
Lumpur, Malaysia
4 University of Malaya, Department of surgery, Kuala Lumpur,
Malaysia
∗ Corresponding author.
Background Depression and anxiety were common psychiatric
morbidity among breast cancer patient. This study aims to study the
level of depression, anxiety, QoL and PSS among Malaysian breast