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S518

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

cancer women over a period of 12 months and their associations at

baseline, 6 and 12 months.

Methods

It is a 12-months prospective cohort study. Two hun-

dred and twenty one female patients were included into the study.

Theywere assessed at the time of diagnosis, 6months and 12month

using Hospital Anxiety and Depression Scale (HADS), Quality-of-

Life Questionnaire (QLQ–C30), Version 3.0 and Multidimensional

Scale of Perceived Social Support (MSPSS). Relevant socio-clinical

characteristic information was collected.

Results

The HADS anxiety and depression subscales scores of the

subjects were relatively low. The level of anxiety reduced signifi-

cantly at 6 and 12 months (baseline – 6 months,

P

= 0.002; baseline

– 12 months,

P

< 0.001). There were no changes in the level of

depression over the study period. The global status of QoL and

MSPSS scores were relatively high. There was positively correlation

between the global status of QoL and MSPSS for the study sub-

jects (Spearman’s rho = 0.31–0.36). Global status of QoL and MSPSS

scores were negatively correlated with anxiety and depression.

Conclusion

Malaysian breast cancer women had relatively bet-

ter QoL with lower level of anxiety and depression. Perceived

social support was important associated factor for better QoL with

low level of psychological distress. It reflected the importance of

enhancing and maintaining the social support system for breast

cancer patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1512

EV528

Impact of pain and remission in the

functioning of patients with

depression in China

D. Novick

1 ,

, Q. Shi

2

, L. Yue

2

, W. Montgomery

3

, M.V. Moneta

4

,

S. Siddi

4 , 5 , J. M

. Haro

4

1

Eli Lilly and Company, Windlesham, Surrey, UK

2

Lilly Suzhou Pharmaceutica Company, Ltd., Shanghai, China

3

Eli Lilly Australia Pty Ltd, West Ryde, Australia

4

Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu,

CIBERSAM, Universitat de Barcelona, Barcelona, Spain

5

Section of Clinical Psychology, Department of Education,

Psychology, Philosophy, University of Cagliari, Italy

Corresponding author.

Introduction

Major depressive disorder (MDD) is the second

leading cause of disability in China.

Objective

To analyze functioning during the course of treating

MDD in China, Taiwan and Hong Kong.

Aims

To study the influence of pain and clinical remission on

functioning.

Methods

This was a post-hoc analysis of a 6-month, prospec-

tive, observational study (

n

= 909) with 422 patients enrolled from

China (

n

= 205; 48.6%), Taiwan (

n

= 199; 47.2%) and Hong Kong

(

n

= 18; 4.2%). Functioning was measured with the Sheehan Dis-

ability Scale (SDS), pain with the Somatic Symptom Inventory,

and severity of depression with the Quick Inventory of Depressive

Symptomatology-Self Report 16 (QIDS). Patients were classified as

having no pain, persistent pain (pain at any visit) or remitted pain

(pain only at baseline). Amixedmodel with repeatedmeasures was

fitted to analyze the relationship between pain and functioning.

Results

At baseline, 40% of the patients had painful physical

symptoms. Patients with pain had a higher QIDS and lower SDS

(

P

< 0.05) at baseline. At 6months, patients with persistent pain had

lower functioning (

P

< 0.05). The regression model confirmed that

clinical remission was associated with higher functioning at end-

point and that patients with persistent pain had lower functioning

at endpoint when compared with the no pain group.

Conclusions

Patients presenting with pain symptoms had lower

functioning at baseline. At 6 months, pain persistence was

associated with significantly lower functioning as measured by the

SDS. Clinical remission was associated with better functional out-

comes. The course of pain was related to the likelihood of achieving

remission.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1513

EV529

Prevalence of involuntary

hospitalization in patients with

depressive disorders

Á. Palma Conesa

1 , 2 ,

, F.N. Dinamarca Cáceres

1 , 2

,

M. Grifell Guardia

1 , 2

, L. Galingo Guarin

1 , 2

,

L. González Contreras

1

, M.T. Campillo Sanz

1

, V. Pérez Solà

1 , 2

1

Institut de Neuropsiquiatria i Addiccions-Parcde Salut Mar –

Barcelona – Spain, Psiquiatry, Barcelona, Spain

2

Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-Parc de

Salut Mar-Barcelona-Spain, Psychiatry, Barcelona, Spain

Corresponding author.

Introduction

Depression is a disabling disorder with a high socio-

economic impact. It might require hospitalization for symptom

control and/or harm prevention. Other depressive disorders might

as well require hospitalization in benefit of the patient. Hos-

pitalization may be involuntary. Hospitalization willfulness in

depressive patients has not been systematically studied in recent

years.

Objective

The aimof this study is to explore the necessity of invol-

untary hospitalization in patients presenting depressive symptoms

at the emergency service that were later diagnosed with a depres-

sive disorder.

Materials and methods

From all patients visited in the psychi-

atric emergency service from 2012 to April 2015 those that were

hospitalized in the acute mental health unit and diagnosed with

a depressive disorder were studied. All those monopolar depres-

sion diagnoses were considered, excluding those within the bipolar

spectrum. Diagnosis followed CIE-9 criteria. A descriptive cross-

sectional study of the samples was then conducted. Statistical

analysis was performed using SPSS software (SPSS Inc., Chicago,

Ill.).

Results

From all 385 depressive disorders, 169 were involuntary

admissions (43.9%), 196were voluntary (50.9%) and 20were sched-

uled (5.2%), difference was statistically significant (

P

< 0.05). Mean

age, was 59.52 years for involuntary admissions, 61.7 for volun-

tary and 63.6 years for scheduled, with a statistically significant

difference (

P

< 0.05). Gender differences were not significant.

Conclusions

Most depressive disorders were hospitalized vol-

untarily. However, a relevant percentage of patients required

involuntary hospitalization. Younger patients presented a higher

ratio of involuntary hospitalization. Reasons for involuntary hospi-

talization needs should be further studied.

Disclosure of interest

The authors have not supplied their dec-

laration of competing interest. Liliana Galindo is a Rio Hortega

fellowship (ISC-III; CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1514

EV530

Defense mechanism maturity and the

severity of depressive symptoms

M. Pandˇza

1 ,

, M. Klari´c

2

, S. Lovri´c

2

, I. ˇColak

2

, J. Mandari´c

2

1

University of Mostar, Department of Psychology, Mostar, Bosnia

and Herzegovina

2

University Hospital Mostar, Psychiatry Clinic, Mostar, Bosnia and

Herzegovina

Corresponding author.