European Psychiatry - Volume 33 - March 2016

530 / 812

S526 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Tracts connecting FC-impaired regions were selected to count fiber
number (FN) and to calculate average FA, AD and RD of all vox-
els along these fibers. Partial correlation analyses were applied to
examine cognitive association of these altered FC and SC, control-
ling the effects of age and education.
Results LOD patients showed decreased FC between PCC/Pcu and
dACC as well as the thalamus. Decreased FA and increased RD of
these fiber tracks connecting PCC/Pcu with dACC were found in
LOD patients, without significant difference in AD and FN. The FC
between PCC/Pcu and dACC was positively correlated with the FA
of fiber tracks connecting them. The PCC/Pcu-dACC FC and the FA
of the fiber tracks between them were both positively correlated
with Symbol Digit Modalities Test and Verbal Fluency Test scores
which conversely displayed negative association with RD.
Conclusions The cognitive impairment in LOD, especially exec-
utive speed and semantic memory might be associated with the
decreased FC in DMN which probably resulted from the demyeli-
nation of the white matter.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV552
Consensus statements on cognitive
dysfunction in depression in the UK:
Rationale and process for gaining
consensus
A.H. Young ∗, K. Bones , G. Goodwin , J. Harrison , C. Katona ,
H. McAllister-Williams , J. Rasmussen , S. Strong
1 Institute of Psychiatry, Psychology and Neuroscience IoPPN,
Psychological Medicine, London, United Kingdom
2 Sussex Partnership NHS Foundation Trust, Occupational Therapy
and Recovery Practice, Sussex, United Kingdom
3 Oxford University, Department of Psychiatry, Oxford, United
Kingdom
4 VU University Medical Center, Alzheimer Center, Amsterdam,
Netherlands
5 University College London, Psychiatry of the Elderly, London, United
Kingdom
6 Institute of Neuroscience, Newcastle University, Academic
Psychiatry and Regional Affective Disorders Service, Newcastle,
United Kingdom
7 Moat House Clinic, General Practice, Surrey, United Kingdom
8 Depression Alliance, Support Group, Croydon, United Kingdom
∗ Corresponding author.
Introduction Cognitive dysfunction is an important aspect of
depression that includes problems with thinking, concentration
and memory. Research suggests that the cognitive aspect of
depression is highly prevalent and has a significant impact on
patient functioning. Currently, cognitive dysfunction in depression
is largely unrecognised, unmonitored and untreated.
Aims We aim to define cognitive dysfunction in clinical depres-
sion (major depressive disorder) and explore its detection and
management in the UK, highlighting priority areas to be addressed.
Methods A modified Delphi method was used as the process to
gain consensus. Amulti-stakeholder steering committee of depres-
sion experts (including psychiatrists, psychologists, primary care
physicians, and representatives from occupational therapy and a
depression charity) provided the key themes and, through round-
table discussion, developed draft statements. The main areas of
focus were burden, detection and management of cognitive dys-
function in depression. These statements formed a questionnaire to
be reviewed by 150–200 health-care professionals with an involve-
ment in the management of depression, with level of agreement
noted as ‘strongly disagree’, ‘disagree’, ‘don’t know/uncertain’,
‘agree’ or ‘strongly agree’. Responses to the questionnaire will be
analysed (very high agreement [> 66%] or very low agreement
[< 33%]) and the steering committee will revise and finalise the
consensus statements, and identify priority areas for future con-
sideration. The steering committee was initiated and supported by
the pharmaceutical company Lundbeck Ltd, through an educational
grant. Lundbeck Ltd did not influence content.
Results Results of the questionnaire and the evolution of the final
consensus statements will be presented.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Eating disorders
EV553
Food, body image, perfectionism
R. Alonso Díaz ∗, E. Cortázar Alonso ,
H. Guillén Rodrigo , S. Fuentes Márquez , R. Remesal Cobreros
1 Huelva, Spain
2 Hospital Juan Ramón Jiménez, Salud Mental, Huelva, Spain
∗ Corresponding author.
Introduction The eating disorder (ED) are anorexia nervosa,
bulimia and unspecified eating disorder behavior according to ICD-
10. Currently the EDhave become a social and health problemof the
first kind that require specialized and interdisciplinary approach to
the response of such disorders.
The growing demand observed in different assistive devices is
associated with increased incidence of eating disorders in recent
decades.
Case description She is a woman of 23 years old, single. It is the
small two brothers. He lives with his parents and brother 25 years.
It is fourth-year student of law. It is derived from primary care by
their GP after significant weight loss by decreasing the intake of
foods high in calories and low mood. It is defined as a very respon-
sible person, controller and is always looking for perfection in every
activity performed. He began to try to lose weight about a year that
relates to start time of stress ago. She speaks that had many exams
and wanted to get top marks in all. With good adherence to psy-
chotherapy and monitoring by nurses. Aspects of body image as
well as traits such as perfectionism work.
Conclusions These clinical conditions are characterized by their
complexity and diversity symptomatology, which involves a sig-
nificant interference in their functioning in different vital areas
and clinically significant distress. After the psychotherapeutic
approach, a significant reduction in the clinic that she had at the
beginning and an improvement in mood was observed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV554
Full of nothing
E. Cortazar Alonso∗, H. Guillen Rodrigo ,
S. Fuentes Marquez
Hospital Juan Ramón Jiménez, Salud Mental, Huelva, Spain
∗ Corresponding author.
The eating disorders like anorexia, bulimia nervosa, and obesity are
known and described from the principles of Western civilization.
Eating disorders affect a large number of people, which about the
90–95% of them are women. Not to forget is their multicausality.
Though their etiology is not exactly known yet, being on a diet is
the most important predictor of having an eating disorders.
We summarize here a case of R. a 30-year-old woman, who vis-
ited the Infant Mental Health Institut for the first time at the age