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S526

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Tracts connecting FC-impaired regions were selected to count fiber

number (FN) and to calculate average FA, AD and RD of all vox-

els along these fibers. Partial correlation analyses were applied to

examine cognitive association of these altered FC and SC, control-

ling the effects of age and education.

Results

LOD patients showed decreased FC between PCC/Pcu and

dACC as well as the thalamus. Decreased FA and increased RD of

these fiber tracks connecting PCC/Pcu with dACC were found in

LOD patients, without significant difference in AD and FN. The FC

between PCC/Pcu and dACC was positively correlated with the FA

of fiber tracks connecting them. The PCC/Pcu-dACC FC and the FA

of the fiber tracks between them were both positively correlated

with Symbol Digit Modalities Test and Verbal Fluency Test scores

which conversely displayed negative association with RD.

Conclusions

The cognitive impairment in LOD, especially exec-

utive speed and semantic memory might be associated with the

decreased FC in DMN which probably resulted from the demyeli-

nation of the white matter.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1536

EV552

Consensus statements on cognitive

dysfunction in depression in the UK:

Rationale and process for gaining

consensus

A.H. Young

1 ,

, K. Bones

2

, G. Goodwin

3

, J. Harrison

4

, C. Katona

5

,

H. McAllister-Williams

6

, J. Rasmussen

7

, S. Strong

8

1

Institute of Psychiatry, Psychology and Neuroscience IoPPN,

Psychological Medicine, London, United Kingdom

2

Sussex Partnership NHS Foundation Trust, Occupational Therapy

and Recovery Practice, Sussex, United Kingdom

3

Oxford University, Department of Psychiatry, Oxford, United

Kingdom

4

VU University Medical Center, Alzheimer Center, Amsterdam,

Netherlands

5

University College London, Psychiatry of the Elderly, London, United

Kingdom

6

Institute of Neuroscience, Newcastle University, Academic

Psychiatry and Regional Affective Disorders Service, Newcastle,

United Kingdom

7

Moat House Clinic, General Practice, Surrey, United Kingdom

8

Depression Alliance, Support Group, Croydon, United Kingdom

Corresponding author.

Introduction

Cognitive dysfunction is an important aspect of

depression that includes problems with thinking, concentration

and memory. Research suggests that the cognitive aspect of

depression is highly prevalent and has a significant impact on

patient functioning. Currently, cognitive dysfunction in depression

is largely unrecognised, unmonitored and untreated.

Aims

We aim to define cognitive dysfunction in clinical depres-

sion (major depressive disorder) and explore its detection and

management in the UK, highlighting priority areas to be addressed.

Methods

A modified Delphi method was used as the process to

gain consensus. Amulti-stakeholder steering committee of depres-

sion experts (including psychiatrists, psychologists, primary care

physicians, and representatives from occupational therapy and a

depression charity) provided the key themes and, through round-

table discussion, developed draft statements. The main areas of

focus were burden, detection and management of cognitive dys-

function in depression. These statements formed a questionnaire to

be reviewed by 150–200 health-care professionals with an involve-

ment in the management of depression, with level of agreement

noted as ‘strongly disagree’, ‘disagree’, ‘don’t know/uncertain’,

‘agree’ or ‘strongly agree’. Responses to the questionnaire will be

analysed (very high agreement [> 66%] or very low agreement

[< 33%]) and the steering committee will revise and finalise the

consensus statements, and identify priority areas for future con-

sideration. The steering committee was initiated and supported by

the pharmaceutical company Lundbeck Ltd, through an educational

grant. Lundbeck Ltd did not influence content.

Results

Results of the questionnaire and the evolution of the final

consensus statements will be presented.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1537

Eating disorders

EV553

Food, body image, perfectionism

R. Alonso Díaz

1 ,

, E. Cortázar Alonso

2

,

H. Guillén Rodrigo

2

, S. Fuentes Márquez

2

, R. Remesal Cobreros

2

1

Huelva, Spain

2

Hospital Juan Ramón Jiménez, Salud Mental, Huelva, Spain

Corresponding author.

Introduction

The eating disorder (ED) are anorexia nervosa,

bulimia and unspecified eating disorder behavior according to ICD-

10. Currently the EDhave become a social and health problemof the

first kind that require specialized and interdisciplinary approach to

the response of such disorders.

The growing demand observed in different assistive devices is

associated with increased incidence of eating disorders in recent

decades.

Case description

She is a woman of 23 years old, single. It is the

small two brothers. He lives with his parents and brother 25 years.

It is fourth-year student of law. It is derived from primary care by

their GP after significant weight loss by decreasing the intake of

foods high in calories and low mood. It is defined as a very respon-

sible person, controller and is always looking for perfection in every

activity performed. He began to try to lose weight about a year that

relates to start time of stress ago. She speaks that had many exams

and wanted to get top marks in all. With good adherence to psy-

chotherapy and monitoring by nurses. Aspects of body image as

well as traits such as perfectionism work.

Conclusions

These clinical conditions are characterized by their

complexity and diversity symptomatology, which involves a sig-

nificant interference in their functioning in different vital areas

and clinically significant distress. After the psychotherapeutic

approach, a significant reduction in the clinic that she had at the

beginning and an improvement in mood was observed.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1538

EV554

Full of nothing

E. Cortazar Alonso

, H. Guillen Rodrigo ,

S. Fuentes Marquez

Hospital Juan Ramón Jiménez, Salud Mental, Huelva, Spain

Corresponding author.

The eating disorders like anorexia, bulimia nervosa, and obesity are

known and described from the principles of Western civilization.

Eating disorders affect a large number of people, which about the

90–95% of them are women. Not to forget is their multicausality.

Though their etiology is not exactly known yet, being on a diet is

the most important predictor of having an eating disorders.

We summarize here a case of R. a 30-year-old woman, who vis-

ited the Infant Mental Health Institut for the first time at the age