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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S525

EV548

Assessment of sexual dysfunctions in

patients diagnosed with major

depressive disorder

D. Vasile

, O. Vasiliu , D.G. Vasiliu , F. Vasile

Central University and Emergency Military Hospital “Dr. Carol

Davila”, Psychiatry, Bucharest, Romania

Corresponding author.

Introduction

Evaluation of sexual dysfunctions in psychiatric

population is an often underestimated problem by many clinicians,

and therefore, this kind of dysfunctions remain undertreated. The

quality of patients’ life is affected by sexual problems and address-

ing these issues in a comprehensive psychiatric therapy could be

associated with higher rates of overall clinical improvement.

Objective

To assess the incidence of sexual dysfunctions in

patients diagnosed with major depressive disorder (MDD) using

structured methods.

Methods

A group of 55 patients (female

n

= 35, male

n

= 20) diag-

nosed with MDD according to DSM 5 criteria were evaluated using

Sexual Dysfunctions Questionnaire (SDQ) – a self administrated

instrument, UKU Side Effects Rating Scale (UKU-SERS) – clinician

rated version, and Hamilton Depression Scale (HAMD). All patients

received stable dose of antidepressant medication for at least 14

days.

Results

A number of 16 patients (29%) reported an SDQ mean

value above 45, which is considered the cut-off score, more fre-

quently men (

n

= 10) than women (

n

= 6). The mean value of SDQ

in this group was 52.3, and the most affected domains were libido

(both men and women) and arousal (especially in women). UKU-

SERS detected a correlation of higher scoreswith the use of selective

serotonin reuptake inhibitors (SSRIs) (almost 48% of these patients)

than with the use of other antidepressants (

P

< 0.05), while the SDQ

scores correlated better with the HAMD values.

Conclusions

Assessment of sexual dysfunctions in patients with

major depressive disorder is needed, both due to the depression

itself and to the side effects of antidepressants.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1533

EV549

Effect of a single nights’ wake

followed by bright light therapy on

agitation

M. Widmark-Jensen

1 ,

, S. Steingrimsson

2

, Z. Szabó

1

1

Sahlgrenska University Hospital, Clinical Department of Psychiatry,

Gothenburg, Sweden

2

Institute of Neuroscience and Physiology, Sahlgrenska Academy,

Gothenburg, Sweden

Corresponding author.

Introduction

Wake-therapy (or “Sleep deprivation”) has the

potential of providing a fast anti-depressive response as add-on

treatment to pharmaceutical intervention. Agitation in a depressive

state is well known and is often associated with interrupted sleep.

Although hypomanic symptoms have been reported following a

single nights wake, agitation has not been examined.

Objective

To examine if agitation increases among inpatients

undergoing wake-therapy compared to treatment as usual (TAU).

Methods

Admitted patients suffering from a depressive episode

will be randomized to either wake-therapy combined with bright

light therapy in addition to TAU, including medication, or to TAU

alone. Before wake-therapy, patients are assessed using PANSS-EC,

aimed at measuring only agitation. The day after a single nights

wake, the assessment will be repeated. Likewise, agitation will be

assessed in the control group directly after randomization as well

as the day after.

Results

In this trial, 50 patientswill be randomized for treatment.

Results concerning agitation among patients that have undergone

the trial will be presented.

Conclusions

Agitation as a side effect of wake-therapy has been

scarcely investigated and this randomized trial will contribute to

the knowledge of agitation following wake-therapy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1534

EV550

The effects of antidepressants and the

quality of low and slow reduction

O. Yakovlev

Private Practice Berlin-Schöneberg, Berlin, Germany

The depression is worldwide one of the most frequent and most

serious illnesses with a raised relapse risk and a raised mortality.

Besides biological psychological and social factors are also other

important factors, as a conflicts and unemployment.

Four million German citizens suffer from depression. Every 5th

German falls ill in the course of his life once with a depression.

Women fall ill 2–3

×

more often with depression than men. In

Germany, 1.5 milliard euros of costs originate on the basis of

depression.

The majority of 10,000 suicides and 150,000 suicide attempts per

year decrease to a not optimally treated depression.

A raised mortality of depressive illnesses is to be led back

on negative influence on heart illness and diabetes mellitus.

Antidepressants show a mood-lightening effect of the depressive

Syndrome, and also depression-related anxiety. The average rate

of the patients, with positive drug response lies in all antidepres-

sant groups in 50–75%. Antidepressants are also used with positive

effect by pain, fear illnesses and compulsive disorder as well as

stress illness. The full effect develops after some days till weeks. It

is important to understand the side effects without changing the

strategy because of Depression-related anxiety. In the course of a

treatment are some side effects (especially vegetative symptoms)

possible, without the dosage must be changed. Anxiety symptoms

of depression improved in more than 90% of patients (depression-

related anxiety). The slow reduction of antidepressants is the gold

standard in the therapy and need a good setting andmood stability.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1535

EV551

Structural integrity and functional

connectivity of default mode network

underlying the cognitive impairment

in Late-onset depression

Y. Yin

Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of

Southeast University, Department of Psychosomatics and Psychiatry,

ZhongDa Hospital, School of Medicine, Southeast University, Nanjing,

China

Objective

To determine the association between the functional

changes and the structural lesions of the DMN underlying the cog-

nitive impairments in Late-onset depression (LOD).

Methods

Thirty-two LOD patients and thirty-nine normal con-

trols (NCs) were recruited and underwent resting-state fMRI and

DTI scans. Cognition was evaluated with MMSE and a battery of

neuropsychological measurements. Seed-based correlation analy-

sis was performed to explore the functional connectivity (FC) of

the DMN. Then deterministic tractography between FC-impaired

regions were calculated to examine structural connectivity (SC).