European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S525
EV548
Assessment of sexual dysfunctions in
patients diagnosed with major
depressive disorder
D. Vasile ∗, O. Vasiliu , D.G. Vasiliu , F. Vasile
Central University and Emergency Military Hospital “Dr. Carol
Davila”, Psychiatry, Bucharest, Romania
∗ Corresponding author.
Introduction Evaluation of sexual dysfunctions in psychiatric
population is an often underestimated problem by many clinicians,
and therefore, this kind of dysfunctions remain undertreated. The
quality of patients’ life is affected by sexual problems and address-
ing these issues in a comprehensive psychiatric therapy could be
associated with higher rates of overall clinical improvement.
Objective To assess the incidence of sexual dysfunctions in
patients diagnosed with major depressive disorder (MDD) using
structured methods.
Methods A group of 55 patients (female n = 35, male n = 20) diag-
nosed with MDD according to DSM 5 criteria were evaluated using
Sexual Dysfunctions Questionnaire (SDQ) – a self administrated
instrument, UKU Side Effects Rating Scale (UKU-SERS) – clinician
rated version, and Hamilton Depression Scale (HAMD). All patients
received stable dose of antidepressant medication for at least 14
days.
Results A number of 16 patients (29%) reported an SDQ mean
value above 45, which is considered the cut-off score, more fre-
quently men (n = 10) than women ( n = 6). The mean value of SDQ
in this group was 52.3, and the most affected domains were libido
(both men and women) and arousal (especially in women). UKU-
SERS detected a correlation of higher scoreswith the use of selective
serotonin reuptake inhibitors (SSRIs) (almost 48% of these patients)
than with the use of other antidepressants (P < 0.05), while the SDQ
scores correlated better with the HAMD values.
Conclusions Assessment of sexual dysfunctions in patients with
major depressive disorder is needed, both due to the depression
itself and to the side effects of antidepressants.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV549
Effect of a single nights’ wake
followed by bright light therapy on
agitation
M. Widmark-Jensen ∗, S. Steingrimsson , Z. Szabó
1 Sahlgrenska University Hospital, Clinical Department of Psychiatry,
Gothenburg, Sweden
2 Institute of Neuroscience and Physiology, Sahlgrenska Academy,
Gothenburg, Sweden
∗ Corresponding author.
Introduction Wake-therapy (or “Sleep deprivation”) has the
potential of providing a fast anti-depressive response as add-on
treatment to pharmaceutical intervention. Agitation in a depressive
state is well known and is often associated with interrupted sleep.
Although hypomanic symptoms have been reported following a
single nights wake, agitation has not been examined.
Objective To examine if agitation increases among inpatients
undergoing wake-therapy compared to treatment as usual (TAU).
Methods Admitted patients suffering from a depressive episode
will be randomized to either wake-therapy combined with bright
light therapy in addition to TAU, including medication, or to TAU
alone. Before wake-therapy, patients are assessed using PANSS-EC,
aimed at measuring only agitation. The day after a single nights
wake, the assessment will be repeated. Likewise, agitation will be
assessed in the control group directly after randomization as well
as the day after.
Results In this trial, 50 patientswill be randomized for treatment.
Results concerning agitation among patients that have undergone
the trial will be presented.
Conclusions Agitation as a side effect of wake-therapy has been
scarcely investigated and this randomized trial will contribute to
the knowledge of agitation following wake-therapy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV550
The effects of antidepressants and the
quality of low and slow reduction
O. Yakovlev
Private Practice Berlin-Schöneberg, Berlin, Germany
The depression is worldwide one of the most frequent and most
serious illnesses with a raised relapse risk and a raised mortality.
Besides biological psychological and social factors are also other
important factors, as a conflicts and unemployment.
Four million German citizens suffer from depression. Every 5th
German falls ill in the course of his life once with a depression.
Women fall ill 2–3× more often with depression than men. In
Germany, 1.5 milliard euros of costs originate on the basis of
depression.
The majority of 10,000 suicides and 150,000 suicide attempts per
year decrease to a not optimally treated depression.
A raised mortality of depressive illnesses is to be led back
on negative influence on heart illness and diabetes mellitus.
Antidepressants show a mood-lightening effect of the depressive
Syndrome, and also depression-related anxiety. The average rate
of the patients, with positive drug response lies in all antidepres-
sant groups in 50–75%. Antidepressants are also used with positive
effect by pain, fear illnesses and compulsive disorder as well as
stress illness. The full effect develops after some days till weeks. It
is important to understand the side effects without changing the
strategy because of Depression-related anxiety. In the course of a
treatment are some side effects (especially vegetative symptoms)
possible, without the dosage must be changed. Anxiety symptoms
of depression improved in more than 90% of patients (depression-
related anxiety). The slow reduction of antidepressants is the gold
standard in the therapy and need a good setting andmood stability.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV551
Structural integrity and functional
connectivity of default mode network
underlying the cognitive impairment
in Late-onset depression
Y. Yin
Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of
Southeast University, Department of Psychosomatics and Psychiatry,
ZhongDa Hospital, School of Medicine, Southeast University, Nanjing,
China
Objective To determine the association between the functional
changes and the structural lesions of the DMN underlying the cog-
nitive impairments in Late-onset depression (LOD).
Methods Thirty-two LOD patients and thirty-nine normal con-
trols (NCs) were recruited and underwent resting-state fMRI and
DTI scans. Cognition was evaluated with MMSE and a battery of
neuropsychological measurements. Seed-based correlation analy-
sis was performed to explore the functional connectivity (FC) of
the DMN. Then deterministic tractography between FC-impaired
regions were calculated to examine structural connectivity (SC).