European Psychiatry - Volume 33 - March 2016

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S506 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Methods We compared the data of women diagnosed with UD
(n = 134) from a larger pool of women seeking treatment for psy-
chiatric disorders from our hospital (n = 609) with HW (n = 100) for
the purpose of this study. The participants were screened using
the MINI International Neuropsychiatric Interview (MINI) and for
childhood abuse using the ISPCANChild Abuse Screening Tool - Ret-
rospective (ICAST)-R. The incidence of childhood abuse between
the two groups was compared using the Chi-squared test.
Results The UD women have significantly more childhood emo-
tional abuse than HW (69.5% vs 30.5%; 2 = 4.819, P< 0.05). There
was no statistically significant difference between the two groups
on overall abuse, physical or sexual abuse (all P > 0.16).
Conclusions Consistent with world literature, significantly more
childhood emotional abuse was seen among Indian women with
UD compared to HW. It is likely that that repeated emotional abuse
in childhood leads to negative attributions among children, later
getting generalised to life events resulting in depression in adult-
hood.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV492
Anxiety and depression in patients
with hepatic versus cardiac disease
A. Dolfi ∗, A. Anton , V. Marinescu
1 Alexandru Obregia Clinical Psychiatric Hospital, Psychiatry 7 Ward,
Bucharest, Romania
2 Carol Davila University of Medicine and Pharmacy, General
Medicine, Bucharest, Romania
∗ Corresponding author.
Background In both hepatic and cardiac disease, a bidirectional
relationship exists between somatic and psychiatric symptoms: is
anxiety/depression caused by the somatic burden of the symptoms
or the psychiatric symptoms and stress are an important patho-
physiologic factor for the somatic disease?
Objective The objectives of our observational study were to see
if any differences exist regarding the anxiety level in patients with
hepatic versus cardiac disease and if the depressive symptomatol-
ogy differs between the two groups of patients.
Materials and methods : We conceived a 2X2 study model
by including two independent variables (the somatic pathology,
hepatic and cardiac) and two dependent variables (anxiety and
depression) which included 66 patients (35 with hepatic and 31
with cardiac pathology) who completed both STAI X1 scale for anx-
iety and BECK scale for depression with good reliability for both
scales (Cronbach’s alpha value of 0.74 for STAI X1 and 0.76 for
BECK), data analyzed with SPSS 17.
Results We obtained a low level for anxiety (mean = 17.76) and a
medium level for depression (mean = 49), both anxiety and depres-
sion level being higher in the patients with hepatic disease versus
cardiac patients (P > 0.05). The patients with hepatic failure had a
higher medium anxiety score (54.66) vs cardiac failure patients
(42.61). The depression score was 19.71 in patients with hepatic
failure and 15.55 in patients with cardiac failure.
Conclusion Both anxiety and depression severity scores were
increased in patients with hepatic disease vs patients with cardiac
disease in the studied groups.
Keywords Anxiety; Depression; Cardiac failure; Hepatic failure
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV493
Clinical status after two-weeks of
antidepressant treatment: A
prognostic factor in unipolar major
depression?
I. Domínguez ∗, L. Nu˜no , G. Oriolo , R. Quintero , V. Navarro ,
C. Gastó
1 Hospital Clínic, Department of Psychiatry and Clinical Psychology,
Barcelona, Spain
2 Hospital Clínic-IDIBAPS-CIBERSAM-UB, Department of Psychiatry
and Clinical Psychology, Barcelona, Spain
∗ Corresponding author.
Although most unipolar depression clinical guidelines advise
against evaluating the efficacy of antidepressant pharmacological
treatment until it has been administered in therapeutic doses for
a minimum of 4–6 weeks, there is an increasing tendency to make
therapeutic decisions after only 2 weeks of treatment. We present
a study which aim is to determine whether the clinical course, fol-
lowing 2 weeks of antidepressant treatment, allows therapeutic
decisions to be made for patients affected by a moderate/severe
depressive episode. The study has an 8-week, prospective, obser-
vational design in which all consecutive in- and outpatients with
moderate/severe unipolar major depression aged over 17 years
received antidepressant treatment based on a standardized treat-
ment protocol. Clinical status was assessed at baseline and at 2-, 4-,
and 8-weeks. The final sample consisted of a total of 114 subjects.
In our sample, the rate of remitters versus non-remitters was simi-
lar between the 2-week improvers and the 2-week non-improvers.
It should also be emphasized that it was not possible to explain,
based on the epidemiological and clinical characteristics assessed,
which 2-week non-improvers would tend towards remission and
which would show a partial or full response. Based on these results,
for patients affected by a moderate/severe unipolar depressive
episode, it would not be appropriate to make new therapeutic
decisions following 2 weeks of anti-depressive pharmacological
treatment depending on whether the patient has shown clinical
improvement or not.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV494
Dysthymia. The importance of an early
diagnosis and an efficient treatment
A. Duque Domínguez ∗, R. Duque Domínguez ,
C. García Montero , L. Martín Díaz , M. Palomo Monge ,
F. de la Torre Brasas , N. Echeverría Hernández ,
M.D.M. Lázaro Redondo
1 Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain
2 Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,
Madrid, Spain
3 Complejo Hospitalario de Talavera de la Reina, Servicio de
Psiquiatría, Talavera de la Reina Toledo, Spain
∗ Corresponding author.
Introduction Dysthymia is defined as a chronic mood disorder
that persists for at least two years in adults, and one year in adoles-
cents and children. It is important to distinguish it from other types
of depression, as early as possible. The therapeutic management of
dysthymia is similar to the one used in major depressive disorder.
Objectives We report the case of a female patient aged 45, diag-
nosed with depressive disorder not otherwise specified since she