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S506

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Methods

We compared the data of women diagnosed with UD

(

n

= 134) from a larger pool of women seeking treatment for psy-

chiatric disorders from our hospital (

n

= 609) with HW (

n

= 100) for

the purpose of this study. The participants were screened using

the MINI International Neuropsychiatric Interview (MINI) and for

childhood abuse using the ISPCANChild Abuse Screening Tool - Ret-

rospective (ICAST)-R. The incidence of childhood abuse between

the two groups was compared using the Chi-squared test.

Results

The UD women have significantly more childhood emo-

tional abuse than HW (69.5% vs 30.5%;

2

= 4.819,

P

< 0.05). There

was no statistically significant difference between the two groups

on overall abuse, physical or sexual abuse (all

P

> 0.16).

Conclusions

Consistent with world literature, significantly more

childhood emotional abuse was seen among Indian women with

UD compared to HW. It is likely that that repeated emotional abuse

in childhood leads to negative attributions among children, later

getting generalised to life events resulting in depression in adult-

hood.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1476

EV492

Anxiety and depression in patients

with hepatic versus cardiac disease

A. Dolfi

1 ,

, A. Anton

2

, V. Marinescu

1

1

Alexandru Obregia Clinical Psychiatric Hospital, Psychiatry 7 Ward,

Bucharest, Romania

2

Carol Davila University of Medicine and Pharmacy, General

Medicine, Bucharest, Romania

Corresponding author.

Background

In both hepatic and cardiac disease, a bidirectional

relationship exists between somatic and psychiatric symptoms: is

anxiety/depression caused by the somatic burden of the symptoms

or the psychiatric symptoms and stress are an important patho-

physiologic factor for the somatic disease?

Objective

The objectives of our observational study were to see

if any differences exist regarding the anxiety level in patients with

hepatic versus cardiac disease and if the depressive symptomatol-

ogy differs between the two groups of patients.

Materials and methods

: We conceived a 2X2 study model

by including two independent variables (the somatic pathology,

hepatic and cardiac) and two dependent variables (anxiety and

depression) which included 66 patients (35 with hepatic and 31

with cardiac pathology) who completed both STAI X1 scale for anx-

iety and BECK scale for depression with good reliability for both

scales (Cronbach’s alpha value of 0.74 for STAI X1 and 0.76 for

BECK), data analyzed with SPSS 17.

Results

We obtained a low level for anxiety (mean = 17.76) and a

medium level for depression (mean = 49), both anxiety and depres-

sion level being higher in the patients with hepatic disease versus

cardiac patients (

P

> 0.05). The patients with hepatic failure had a

higher medium anxiety score (54.66) vs cardiac failure patients

(42.61). The depression score was 19.71 in patients with hepatic

failure and 15.55 in patients with cardiac failure.

Conclusion

Both anxiety and depression severity scores were

increased in patients with hepatic disease vs patients with cardiac

disease in the studied groups.

Keywords

Anxiety; Depression; Cardiac failure; Hepatic failure

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1477

EV493

Clinical status after two-weeks of

antidepressant treatment: A

prognostic factor in unipolar major

depression?

I. Domínguez

1 ,

, L. Nu˜no

1

, G. Oriolo

1

, R. Quintero

1

, V. Navarro

2

,

C. Gastó

2

1

Hospital Clínic, Department of Psychiatry and Clinical Psychology,

Barcelona, Spain

2

Hospital Clínic-IDIBAPS-CIBERSAM-UB, Department of Psychiatry

and Clinical Psychology, Barcelona, Spain

Corresponding author.

Although most unipolar depression clinical guidelines advise

against evaluating the efficacy of antidepressant pharmacological

treatment until it has been administered in therapeutic doses for

a minimum of 4–6 weeks, there is an increasing tendency to make

therapeutic decisions after only 2 weeks of treatment. We present

a study which aim is to determine whether the clinical course, fol-

lowing 2 weeks of antidepressant treatment, allows therapeutic

decisions to be made for patients affected by a moderate/severe

depressive episode. The study has an 8-week, prospective, obser-

vational design in which all consecutive in- and outpatients with

moderate/severe unipolar major depression aged over 17 years

received antidepressant treatment based on a standardized treat-

ment protocol. Clinical status was assessed at baseline and at 2-, 4-,

and 8-weeks. The final sample consisted of a total of 114 subjects.

In our sample, the rate of remitters versus non-remitters was simi-

lar between the 2-week improvers and the 2-week non-improvers.

It should also be emphasized that it was not possible to explain,

based on the epidemiological and clinical characteristics assessed,

which 2-week non-improvers would tend towards remission and

which would show a partial or full response. Based on these results,

for patients affected by a moderate/severe unipolar depressive

episode, it would not be appropriate to make new therapeutic

decisions following 2 weeks of anti-depressive pharmacological

treatment depending on whether the patient has shown clinical

improvement or not.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1478

EV494

Dysthymia. The importance of an early

diagnosis and an efficient treatment

A. Duque Domínguez

1 ,

, R. Duque Domínguez

2

,

C. García Montero

1

, L. Martín Díaz

1

, M. Palomo Monge

3

,

F. de la Torre Brasas

1

, N. Echeverría Hernández

1

,

M.D.M. Lázaro Redondo

1

1

Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain

2

Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,

Madrid, Spain

3

Complejo Hospitalario de Talavera de la Reina, Servicio de

Psiquiatría, Talavera de la Reina Toledo, Spain

Corresponding author.

Introduction

Dysthymia is defined as a chronic mood disorder

that persists for at least two years in adults, and one year in adoles-

cents and children. It is important to distinguish it from other types

of depression, as early as possible. The therapeutic management of

dysthymia is similar to the one used in major depressive disorder.

Objectives

We report the case of a female patient aged 45, diag-

nosed with depressive disorder not otherwise specified since she