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Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S503

Conclusions

Our findings indicate that the RM

20% W2 alone

and in combination with RC may be useful in the prediction of

response to SSRIs. Serum/plasma BDNF did not show strong pre-

dictive potential.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Acknowledgements

This study was supported by the grants of MZ

CR No. AZV 15-29900A, MH CZ - DRO (NIMH-CZ, 00023752) and

projects National Institute of Mental Health (NIMH-CZ) number

ED2.1.00/03.0078 and the European Regional Development Fund.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1466

EV482

Seasonal affective disorder associate

with common chronic diseases and

symptoms in a population-based

study

S. Basnet

1 ,

, I. Merikanto

2

, T. Lahti

3

, T. Partonen

1

1

National Institute for Health and Welfare THL, Department of

Health, Helsinki, Finland

2

National Institute for Health and Welfare-Helsinki Finland,

Department of Health, Helsinki, Finland

3

University of Health, Public health, Helsinki, Finland

Corresponding author.

Background

Seasonal affective disorder (SAD) is a recurrent

mood disorder with 22%–42% of the patients experiencing symp-

toms even after 5–11 years after diagnosis, and 33%–44%

developing non-seasonal symptoms. The purpose of this study was

to assess how seasonality is associated with some of the most

common non-communicable diseases in the general Finnish pop-

ulation.

Methods

The global seasonality score (GSS) and the experiences

of problems due to the seasonal variations from FINNRISK 2012

dataset were used to measure the seasonality in 4689 Finns aged

25–74 years living in five geographical regions in Finland, and

assess their association with common non-communicable diseases

(NCDs). The regression models and odds ratios were adopted to

analyze the associations adjusted for covariates.

Results

The prevalence of SAD in the Finnish general population

is 21%. Seventy percent of the participants had seasonal variations

in sleep duration, social activity, mood and energy level, while 40%

had seasonal variations is weight and appetite. Angina pectoris and

depression were significantly associated with seasonality, includ-

ing seasonal variations in sleep duration, mood, weight, appetite,

social activity and energy level. Depression was significantly asso-

ciated with the increased odds for experiencing a problem due to

the seasonal variations (OR = 4.851,

P

< 0.0001) and SAD symptoms

(OR = 4.075,

P

< 0.0001), and with the GSS (

P

< 0.0001).

Conclusion

Our data suggest that seasonality is associated with

depression and angina pectoris. The co-occurrence of the seasonal

variations in mood and behavior with common NCDs warrants the

need for future research to have insights into the etiology and

potentially shared pathways and mechanisms of action.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1467

EV483

The presence of chronic pain in

patients with major depressive

disorder and its inter-correlation

B. Batinic

1 ,

, J. Nesvanulica

2

, I. Stankovic

2

1

Clinic of Psychiatry- Clinical Centre of Serbia, Faculty of Philosophy-

Department of Psychology, Belgrade, Serbia

2

Faculty of Philosophy, Department of Psychology, Belgrade, Serbia

Corresponding author.

Introduction

Chronic pain is a common experienced symptom

among patients diagnosed with major depressive disorder (MDD).

The intensity of depression and chronic pain inter-correlated, hav-

ing negative impact on the daily functioning of the patients.

Objectives

Our aim was to explore the presence of chronic pain

in patients diagnosed with MDD (single episode or recurrent),

correlation between intensity of depression and chronic pain, its

interference on daily functioning, as well as sex differences regard-

ing the explored variables.

Methods

The study sample consisted of 51 (62.2%) female and 31

(37.8%) male patients diagnosed with MDD (

n

= 82), aged between

18 and 65 years old (mean age of 46.21). Assessment instruments

included The Beck Depression Inventory-II (BDI-II), The Brief Pain

Inventory-Short Form (BPI) (consisting of BPI-I factor of pain inten-

sity, and BPI-II-factor of pain interference with daily functioning),

and semistructured questionnaire for sociodemographic character-

istics.

Results

The presence of chronic pain was found in the 51 (62,

2%) of patients with MDD. The mean score on the BDI-II for the

whole sample was 22.5 (SD 12.8). There was a positive correlation

between intensity of depression (BDI-II) and intensity of chronic

pain (BPI-1), and its interference on the level of daily function-

ing (BPI-2) (

P

< 0.01). Women diagnosed with MDD experienced

chronic pain of higher intensity and with greater interference on

daily functioning.

Conclusion

Our research data show a high frequency of chronic

pain among patients diagnosed with MDD and its positive inter-

correlation which results in negative impact on daily functioning,

especially in females.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1468

EV484

Augmentation strategies in the

treatment of major depressive

disorder

S. Bise

1 ,

, B . K

urtovic

1 , D.

Begic

2 , O.

Cemalovic

2

1

Psychiatric Hospital, women, Sarajevo, Bosnia and Herzegovina

2

Psychiatric Hospital, Intensive care, Sarajevo, Bosnia and

Herzegovina

Corresponding author.

Augmentation strategies for the treatment of Major depressive

disorder (MDD) are needed when patients with MDD have a par-

tial, or not responded to antidepressant monotherapy. The focus

of augmentation therapy has been combining an antidepressant

(AD) medication with another AD. Atypical antipsychotics (AAP)

are becoming commonly used to augment antidepressants. Beyond

AD and AAP, alternative augmentation strategies includemood sta-

bilizers (MS).

Aim

To analyze the characteristics of therapy in patients with

diagnosis of MDD and to investigate the frequency of augmentation

therapy.

Method

Study included 28 patients hospitalized during one year

withMDDdiagnosis. Statistical analysiswas performedwith x2 and

t-test.

Result

Among patients withMDD therewere 18 (64.28%) women

with an average age 57.5 and 10 (35.71%) men with an average

age 53.5. Of the 28 patients with MDD, 25 (89.28%) were treated

with a combination therapy, and monotherapy in the remaining 3

patients (10.71%). Of 25 patients with augmentation strategy treat-

ment, 22 (88%) used two medications and the remaining 3 (12%)

tree psychotropic medications (AAP, AD, MS). The most frequent

combinations were a combination of AD and AAP (17 patients, 68%).

Beyond that frequent combination were AD and MS (6 patients,

24%). Two patients used combination two AAP, and one patient

with two AD and one patients used AAP and MS.