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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S507

was 20. Her psychopathological progress has gradually become

aggravated, having now longer periods of depressive mood and an

important tendency towards isolation.

Methodology

The patient is admitted to the Psychiatric Day

Hospital presenting with important depressive symptoms. After

various antidepressants were withdrawn, lithium salts were intro-

duced. It is then that the patient starts improving her mood.

Results

– Dysthymia (F34.1).

– Mixed and other personality disorders (F61.0).

Conclusions

In spite of having an appropriate pharmacological,

unfortunately, antidepressants improve dysthymia just in 50–70%

of patients. Antidepressants resistant dysthymia cases have been

studied. In those cases, it has been necessary to add lithium or thy-

roxine. This confirms that, when it comes to this disorder, there

are many neurochemical mechanisms involved, given the positive

response to the combination of drugs, notwithstanding the severity

of the adverse effects.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1479

EV495

Assessment of mature serum

brain-derived neurotrophic factor

(BDNF) is not superior to total serum

BDNF in prediction of antidepressant

treatment outcome

A. Eckert

1 ,

, T. Mikoteit

2

, J. Beck

2

, U.M. Hemmeter

3

, S. Brand

4

,

K. Schmitt

1

, R. Bischof

5

, A. Delini-Stula

5

, E. Holsboer-Trachsler

2

1

Psychiatric University Clinics Basel, Neurobiology Lab for Brain

Aging & Mental Health, Basel, Switzerland

2

Psychiatric University Clinics Basel, Center for Affective- Stress and

Sleep Disorders ZASS, Basel, Switzerland

3

Psychiatric Service Canton of St. Gallen, Center of Education and

Research COEUR, Wil SG, Switzerland

4

Psychiatric University Clinics Basel, Center for Affective- Stress and

Sleep Disorders ZASS- Department of Sport- Exercise and Health-

Sport Science Division- Faculty of Medicine, Basel, Switzerland

5

ADI International Institute for Advancement of Drug Development

GmbH, ADI International Institute for Advancement of Drug

Development GmbH, Basel, Switzerland

Corresponding author.

Background

Serum BDNF levels are decreased in major depres-

sive disorder (MDD) and tend to normalize under antidepressant

treatment, serving as a treatment outcome predictor. BDNF is ini-

tially synthetized as precursor protein proBDNF and is cleaved to

mature BDNF (mBDNF) while only the latter exerts neurotrophic

activity.

Aim

The aim was to explore if a specific enzyme-linked

immunosorbent assay (ELISA) kit for mBDNF in serum would be

superior to the unspecific assessment of total serum BDNF in pre-

dicting treatment response in MDD.

Methods

Twenty-five patients with MDD underwent standard-

ized treatment with duloxetine. Severity of depression was

measured by Hamilton Depression Rating Scale (HDRS) at baseline

(BL), after one (W1), two (W2) and six weeks (W6) of treatment.

Treatment response was defined as a HDRS

50% reduction of BL

score at W6. mBDNF and total BDNF serum levels were determined

at BL, W1 and W2.

Results

A high and stable correlation was found between mBDNF

and total BDNF serum levels over all measurements. The predictive

value of mBDNF BL levels and mBDNF W1 to response was sim-

ilar to that of total BDNF BL and total BDNF W1. The assessment

of serum mBDNF was not superior to total BDNF in prediction of

treatment outcome.

Conclusions

Not only baseline total BDNF but also mBDNF is pre-

dictive to treatment outcome. The later might represent the main

player in this respect, which supports the idea of a functional link

between neuroplasticity and MDD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1480

EV496

Computer-based cognitive training

for patients with unipolar depression

A. Elliott

1 ,

, P . M

unk-Jørgensen

2 , A. S

heldrick-Michel

3 ,

M.D. Hell

1 , B. N

ielsen

1

1

Psychiatric Hospital and University of Southern Denmark, Research

Unit of Psychiatry Odense, Odense, Denmark

2

Psychiatric Hospital and University of Southern Denmark,

Psychiatric Research Academy, Odense, Denmark

3

Psychiatric Hospital and University of Southern Denmark,

Department of Affective Disorders Odense, Odense, Denmark

Corresponding author.

Introduction

Unipolar depression is a public health problem and

is the most common psychiatric disorder among people with long-

term sick leave in Denmark. Patients with unipolar depression are

often associated with deficits in cognitive function long after the

affective symptoms have disappeared. This could explain the long-

term sick leave among patients suffering from unipolar depression.

Computer-based cognitive training has been used to increase cog-

nitive function in other patient groups.

Objectives

It is unknown whether cognitive functions are

improved in patients with depression by help of a cognitive com-

puter program. Further we investigate whether this intervention

shortens sick leave.

Aims

To investigate whether a computer-based cognitive train-

ing group present a higher score in cognitive function after training

and return to their employment earlier compared to the control

group.

Methods

The study includes patients who have been admitted

because of depression, but are finished with their treatment. When

the patients are discharged, they will be randomizes into two

groups and evaluated on their cognitive function. Only one of the

two groups will receive computer-based cognitive training. After

12 week the two groups’ cognitive function will be compared. Fur-

thermore there is a six-month follow up, to show if or when the

participants have returned to work.

Results

The results will be presented at the EPA March 2016 in

Madrid.

Conclusion

Based on the results of study it is our intention to

conclude whether or not to implement computer-based cognitive

training in treatment of patients with depression.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1481

EV497

Hyopmagnesium and treatment

resistant depression

F. Estilaee

1 ,

, S . E

stilaee

2 , F. R

aad

3

1

Neshabur Faculty of Medical Science, Psychiatry, Neshabur, Iran

2

Mashhad Medical University of Science, Radiology, Mashhad, Iran

3

Islamic Azad Uinversity-mashhad Branch, Shahinfar Medical

Faculty, Mashhad, Iran

Corresponding author.

Our increasing knowledge about cellular and molecular level of

brain functionality is changing the view on basis of psychological

diseases, like depression, frombrain functionality based diseases to

organic based ones. It is known that changes in hormonal level, like

thyroid, parathyroid, estrogen and progesterone hormones, could

lead to mood deviations. Also the effect of some ions like lithium